Promoter Polymorphism (-174, G/C) of Interleukin-6 and Arterial Thromboembolic Events: A Meta-Analysis

Abstract

BackgroundIschemic stroke and myocardial infarction are fatal diseases and are among the top 10 causes of death in Korea, including arterial thromboembolic events. Many previous studies have described the function of interleukin-6 (IL-6) in arterial thromboembolic events and the association between promoter single-nucleotide polymorphism (SNP) (rs1800795; −174, G/C) of the IL-6 gene. However, these results were controversial. Therefore, we performed a meta-analysis to more precisely assess the association between the SNP of the IL-6 gene and susceptibility to arterial thromboembolic events.Material/MethodsWe used PubMed, Embase, Google Scholar, and Korean Studies Information Service System (KISS) electronic databases. Comprehensive Meta-analysis software (Corporation, NJ) was used to evaluate the relationship between rs1800795 SNP of IL-6 gene and risk of arterial thromboembolic events. Odds ratio (OR), 95% confidence interval (CI), and P value were also calculated. The 13 eligible studies were analyzed in the meta-analysis.ResultsThe present meta-analysis found that rs1800795 SNP of IL-6 gene is not significantly associated with susceptibility to arterial thromboembolic events (C allele vs. G allele, OR=1.04, 95% CI=0.91–1.19, P=0.619; CC vs. CG+GG, OR=1.09, 95% CI=0.91–1.31, P=0.364; CC+CG vs. GG, OR=0.97, 95% CI=0.78–1.21, P=0.763, respectively), and the SNP of IL-6 gene also did not show any significant association with ischemic stroke or myocardial infarction (P>0.05 in each model).ConclusionsWe found that rs1800795 SNP of IL-6 gene was not related to arterial thromboembolic events. However, further study will be needed to confirm these results.

Impact of interleukin 6 promoter polymorphisms (−174 G > C, −572 G > C and −597 G > A) on plasma IL-6 levels and their influence on the development of DVT: a study from India

“…However, there are unequivocal opinions regarding the role of this polymorphism with thrombosis. Our results are in line with two previous studies where they have reported no association of this polymorphism with the risk of ischemic stroke in South Korean and DVT in European population, respectively [6,18]. In contrary to these findings, one recent study suggested marginal association of −174 G > C polymorphism with thrombotic risk in venous and arterial thrombotic disorders in Asian population [19].…”

Association Between Polymorphisms of Interleukin 1 Family Genes and Hepatocellular Carcinoma

“…Odds ratios (OR) and 95% confidence intervals (CI) were calculated for effect of genotypes and allele frequencies at the 5% level of significance. For the logistic regression analysis of genetic data, SNPStats and SPSS 17.0 were used [ 20 ]. Logistic regression analysis was performed to investigate the association between SNPs of the IL-1 family of genes and HCC adjusted by age and sex.…”

“…Logistic regression analysis was performed to investigate the association between SNPs of the IL-1 family of genes and HCC adjusted by age and sex. A linkage disequilibrium (LD) block of polymorphisms was analyzed using Haploview 3.32 [ 20 , 21 ]. The haplotypes and their frequencies were calculated using the EM algorithm.…”

Dual Effect of IL-6 -174 G/C Polymorphism and Promoter Methylation in the Risk of Coronary Artery Disease Among South Indians

“…Several studies have reported that IL-6 -174 polymorphism has been associated with CAD [18,19], type II diabetes mellitus [17]. In a meta-analysis, reported the significant association between the incidence of stroke and IL-6 -174G/C polymorphism [20,21].…”