Genetic polymorphisms of glutathione S-transferase genes GSTP1, GSTM1, and GSTT1 and risk of esophageal and gastric cardia cancers

Zendehdel, Kazem; Bahmanyar, Shahram; McCarthy, Shane; Nyrén, Olof; Andersson, Björn; Ye, Weimin

doi:10.1007/s10552-009-9399-7

Cited by 48 publications

(25 citation statements)

References 29 publications

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“…The null genotypes in GSTT1 and GSTM1 were found in 49 (58.3%) and 48 (57.1%), respectively. When comparing these distributions with healthy Japanese [36][37][38] and Caucasian [39,40], frequency of XRCC1 codon 399 Arg/Arg genotype was slightly higher than that of healthy Japanese and Caucasian, and frequency of XRCC1 codon 194 Arg/Arg genotype was slightly lower than that of healthy Japanese and much lower than that of Caucasian. The frequency of GSTP1 Ile/Ile genotype was slightly lower than that of healthy Japanese and much lower than that of Caucasian.…”

Section: Resultsmentioning

confidence: 99%

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Association between polymorphisms in the XRCC1 and GST genes, and CpG island methylation status in colonic mucosa in ulcerative colitis

et al. 2011

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CpG island hypermethylation (CIHM) is frequently observed in the colonic mucosa in ulcerative colitis (UC) and is deeply involved in UC-associated colorectal carcinogenesis. We evaluated the influence of common polymorphisms related to DNA repair or xenobiotic pathway (XRCC1, GSTP1, GSTT1, and GSTM1) on the individual susceptibility to CIHM status in the non-neoplastic rectal mucosa in UC patients. XRCC1 Arg399Gln and Arg194Trp, GSTP1 Ile104Val, and GSTT1, GSTM1 null polymorphisms were genotyped in 84 UC patients without neoplastic lesions, in relation to CIHM in the rectal mucosa of three candidate CpG loci (p14, p16, and CDH1) assessed by methylation-specific polymerase chain reaction. XRCC1 codon 399 Arg/Gln genotype (odds ratio (OR) = 0.31, 95%CI = 0.12-0.81, p = 0.017) and 399 Gln carrier (GlnGln+Arg/Gln: OR = 0.30, 95%CI = 0.12-0.76, p = 0.01) were significantly associated with reduced susceptibility to CIHM of the CDH1 promoter. GSTP1 Val carrier (Ile Val+Val/Val) also held a significantly lower susceptibility to CIHM of the p16 promoter (OR = 0.26, 95%CI = 0.08-0.86, p = 0.028). In contrast, GSTT1 present genotype (OR = 3.16, 95%CI = 1.27-7.89, p = 0.01) was significantly associated with increased susceptibility to CIHM of the same gene. XRCC1 codon 399 Gln/Gln genotype was significantly associated with lower mean number of CIHM when compared to the Arg/Arg genotype (1.53 ± 1.01 vs. 0.63 ± 1.06, p = 0.024). In addition, the GSTP1 Ile/Val carrier (Ile/Val+Val/Val) was also significantly associated with lower mean number of CIHM (1.43 ± 1.03 vs. 0.84 ± 1.07, p = 0.03). XRCC1 Arg399Gln and GSTP1 Ile104Val polymorphisms may influence the CIHM status in the rectal mucosa of UC patients and may be substantially involved in UC-associated carcinogenesis.

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Section: Resultsmentioning

confidence: 99%

“…Also, the same evaluation will be needed for the risk prediction of sporadic colorectal cancer. Furthermore, the distribution of polymorphisms would vary in different populations [39,40]. A study using a diverse population will also be needed to apply our result to other ethnics.…”

Section: Discussionmentioning

confidence: 98%

Association between polymorphisms in the XRCC1 and GST genes, and CpG island methylation status in colonic mucosa in ulcerative colitis

et al. 2011

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“…13 articles were excluded after reading the full text. Six were not Asians studies (Gonzalez et al, 2004;Martinez et al, 2006;Ruzzo et al, 2007;Wideroff et al, 2007;Zendehdel et al, 2009; Garcia-Gonzalez et al, 2012), and seven were repeating or overlapping publications (Cai et al, 1999;Setiawan et al, 2001; Gao et al, 2002b;Qian et al, 2003; Sheng et al, 2004;Nan et al, 2005b;Tripathi et al, 2008). Finally, 39 articles that report on the effects of GSTT1 polymorphisms on gastric cancer in Asia covering in total of 7,737 gastric cancer cases and 10,823 controls were remained for data extraction.…”

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confidence: 99%

Association of the Glutathione S-transferase T1 Null Genotype with Risk of Gastric Cancer: a Meta-analysis in Asian Populations

Zeng

Bai²,

Deng³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: A large number of studies have been published to investigate the association between the null genotype of glutathione S-transferase T1 (GSTT1) with gastric cancer. However, the results were inconsistent and conflicting. The aim of this study was to estimate the relationship between this polymorphism in the GSTT1 gene and gastric cancer risk in Asian populations by meta-analysis. Materials and Methods: A literature search was performed in PubMed, Embase, Chinese Biomedical database (CBM), Weipu database, Wanfang database, and China National Knowledge Infrastructure database (CNKI). Statistical analysis was conducted by using Review Manager 5.3. Results: Thirty-nine studies with a total of 7,737 gastric cancer cases and 10,823 controls were included in this meta-analysis. The meta-analysis of total studies showed that the null genotype in GSTT1 was associated with increased risk of gastric cancer in Asians (OR=1.19, 95% CI=1.08-1.31, p=0.0002). Subgroup analysis showed a significant relationship between GSTT1 null genotype and gastric cancer in East-Asians, as well as in subgroup analysis of hospital-based design. On subgroup analysis by smoking status, alcohol status, Helicobacter pylori infection status, and histology type, no significant association of this polymorphism with susceptibility to gastric cancer was found. Conclusions: In conclusion, the results showed that the null genotype of GSTT1 is significantly associated with an increased risk in gastric cancer in Asian populations. (Acar et al., 2006;Sreeja et al., 2008;Liu et al., 2010). Polymorphisms in this gene affect the enzymatic activities and the ability to metabolize carcinogenic compounds (Nebert et al., 1999). The most common variant of GSTT1 gene is homozygous deletion (null genotype), which has been reported to be associated with gastric cancer (Hayes and Strange, 2000). However, the sparseness of data or disagreements among the reported investigations results in the available evidence weakly. To assess the effect of GSTT1 null genotype on gastric cancer risk in Asian population more precisely, we conducted most of the related studies and performed this meta-analysis of published data investigating whether the null genotype of GSTT1 gene was associated with the risk of gastric cancer. Keywords Materials and Methods Publication searchA literature search of PubMed, Embase, Chinese Biomedical database (CBM), Weipu database, Wanfang 1142database and Chinese National Knowledge Infrastructure (CNKI) was conducted using combinations of the following keywords: "gastric cancer or gastric carcinoma or gastric neoplasm" and "polymorphism or variant or mutation" and "GSTT1 or glutathione S-transferase T1". The language was limited to Chinese and English. All studies that evaluate the relationship between polymorphisms in GSTT1 gene and gastric cancer risk were retrieved. Studies included in the meta-analysis had to meet all of the following criteria: (1) evaluation of the polymorphisms in GSTT1 gene and gastric cancer risk, (2) use of ...

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“…These studies were performed in a wide range of geographical settings leading to a diversity of racial groups. Among them, 11 studies were performed in Asian countries including China (Setiawan et al, 2001;Roth et al, 2004;Mu et al, 2005;Zhang et al, 2007;Deng et al, 2011;Jiang et al, 2011;Zhang et al, 2011), Japan (Katoh et al, 1999), Vietnam (Nguyen et al, 2010), and Korea (Hong et al, 2006;Kang et al, 2008), while 9 studies were conducted in Caucasians including Sweden (Zendehdel et al, 2009), Indian (Tripathi et al, 2008;Malik et al, 2009;Yadav et al, 2010), Spain (Martinez et al, 2006), Turkey (Tamer et al, 2005), Poland (Lan et al, 2001), and USA (Wideroff et al, 2007). Genotype distribution in control groups were in HWE except for 4 studies (Katoh et al, 1999;Tamer et al, 2005;Jiang et al, 2011;Zhang et al, 2011).The detailed characteristics of the included studies were shown in the Table 1.…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

“…However, these studies provided conflicting results. Some studies indicated that the GSTP1 val allele was associated with increased risk of GC (Zhang et al, 2007;Zendehdel et al, 2009;Deng et al, 2011;Jiang et al, 2011), while other studies showed no association (Wideroff et al, 2007;Kang et al, 2008;Nguyen et al, 2010;Yadav et al, 2010), and even associated with reduced risk of GC (Martinez et al, 2006). To make a more accurate estimate of the association between GSTP1 and risk of GC, we performed a metaanalysis from all eligible studies.…”

mentioning

confidence: 99%

Association Between the GSTP1 Codon 105 Polymorphism and Gastric Cancer Risk: an Updated Meta-analysis

Jing¹,

Song²,

Wang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Genetic polymorphisms of glutathione S-transferase genes GSTP1, GSTM1, and GSTT1 and risk of esophageal and gastric cardia cancers

Cited by 48 publications

References 29 publications

Association between polymorphisms in the XRCC1 and GST genes, and CpG island methylation status in colonic mucosa in ulcerative colitis

Association between polymorphisms in the XRCC1 and GST genes, and CpG island methylation status in colonic mucosa in ulcerative colitis

Association of the Glutathione S-transferase T1 Null Genotype with Risk of Gastric Cancer: a Meta-analysis in Asian Populations

Association Between the GSTP1 Codon 105 Polymorphism and Gastric Cancer Risk: an Updated Meta-analysis

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