Association Between the GSTP1 Codon 105 Polymorphism and Gastric Cancer Risk: an Updated Meta-analysis

Jing, Niu; Song, Hui; Wang, Yi; Ma, Rong; Ren, Xian-Hua; Wu, Xin-Lin

doi:10.7314/apjcp.2012.13.8.3687

Cited by 10 publications

(8 citation statements)

References 33 publications

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“…The results indicated that GSTP1 polymorphism was not significantly associated with prostate cancer 30, esophageal cancer 32, head and neck cancer 33, lung cancer 34, ovarian cancer 36 and thyroid cancer 37; this polymorphism might contribute to the development of gastric cancer 31 or breast cancer 35 in East Asians, but not in other ethnic populations. However, besides our study, these meta-analyses did not consider the effect of gene-gene and gene-environment interactions in the development of cancer.…”

Section: Discussionmentioning

confidence: 88%

“…Recently, many meta-analyses have been performed to investigate the association between GSTP1 Ile105Val polymorphism and many types of cancer risk (e.g., prostate cancer 30, gastric cancer 31, esophageal cancer 32, head and neck cancer 33, lung cancer 34, breast cancer 35, ovarian cancer 36 and thyroid cancer 37). The results indicated that GSTP1 polymorphism was not significantly associated with prostate cancer 30, esophageal cancer 32, head and neck cancer 33, lung cancer 34, ovarian cancer 36 and thyroid cancer 37; this polymorphism might contribute to the development of gastric cancer 31 or breast cancer 35 in East Asians, but not in other ethnic populations.…”

Section: Discussionmentioning

confidence: 99%

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Glutathione S-transferase P1 Ile105Val Polymorphism and Oral Cancer Risk: A Meta-Analysis

Li¹,

Chen²,

Liu³

2013

Int. J. Med. Sci.

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Objective The glutathione S-transferase P1 (GSTP1) gene has been suggested to play an important role in the pathogenesis of oral cancer. However, the results have been inconsistent. In this study, we performed a meta-analysis to clarify the association of GSTP1 Ile105Val polymorphisms with oral cancer risk.Methods Published literature from PubMed and EMBASE were retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model.Results 13 studies (1803 oral cancer cases and 2998 controls) for GSTP1 Ile105Val polymorphism were included in the meta-analysis. The results indicated that there was no significant association between GSTP1 Ile105Val polymorphism and oral cancer in the overall population (OR=1.30, 95%CI=0.92-1.38, I2=48.0%, p for heterogeneity=0.027). Further subgroup analysis by ethnicity suggested that GSTP1 Ile105Val polymorphism was significantly associated with oral cancer only in East Asians (OR=1.64, 95%CI=1.16-2.31, I2=0.0%, p for heterogeneity=0.525), but not in Caucasians (OR=1.16, 95%CI=0.73-1.82, I2=7.5%, p for heterogeneity=0.299), Africans (OR=1.10, 95%CI=0.37-3.28), South Asians (OR=1.20, 95%CI=0.69-2.08, I2=74.3%, p for heterogeneity=0.021) and mixed population (OR=0.91, 95%CI=0.70-1.20, I2=39.7%, p for heterogeneity=0.174).Conclusions The present meta-analysis has limited evidence to support the association of GSTP1 Ile105Val polymorphism with HCC risk in the overall population. However, GSTP1 Ile105Val polymorphism might be associated with risk of oral cancer in East Asians.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Glutathione S-transferase P1 Ile105Val Polymorphism and Oral Cancer Risk: A Meta-Analysis

Li¹,

Chen²,

Liu³

2013

Int. J. Med. Sci.

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“…A funnel plot of each of the pairs of groups compared above was created with the OR as the x-axis and the SE (log[OR)]) as the y-axis. If this plot was symmetric, it would suggest that the publication bias was minimal and that the results of the present study arecredible.Begg's and Egger's tests can be used to quantify the publication biases of studies in all circumstances[23]. The results of the Begg's and Egger's tests revealed that no publication biases existed in terms of gender (Fig 13A), age (Fig 13B), tumour stage (Fig 13E), lymph node metastasis (Fig 13F), TNM stage (Fig 13H), differentiation(Fig 13I) or Lauren type (Fig 13J).…”

Section: Resultsmentioning

confidence: 99%

Relationship between epithelial cell adhesion molecule (EpCAM) overexpression and gastric cancer patients: A systematic review and meta-analysis

Dai

Yuan

et al. 2017

PLoS ONE

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ObjectivesThe epithelial cell adhesion molecule (EpCAM) is one of the most commonly used markers of cancer stem cells (CSCs), but the clinical and prognostic significance of EpCAM in gastric cancer (GC) remains disputable. Motivated by heterogeneous and inconclusive results, we conducted a systematic review and meta-analysis to systematically summarize and elucidate the association between EpCAM overexpression and GC patients.MethodsThe PubMed, Cochrane Library, Medline, Web of Knowledge and the China National Knowledge Infrastructure (CNKI) databases were searched to identify relevant studies. The RevMan 5.3 software was used for the meta-analysis. Fixed-effects or random-effects models were applied depending on the presence of heterogeneity. The pooled odds ratio (ORs) and 95% confidence intervals (CIs) were applied to estimate the associations between EpCAM and gastric cancer. For the significant heterogeneity studies, sensitivity analyses were applied based on the population to test the robustness of the pooled results and identify possible sources of heterogeneity.ResultsA total of 11 studies including 1960 GC patients met our inclusion criteria. The results of the meta-analyses revealed that there were significant differences in EpCAM overexpression and tumour size (OR = 2.97, 95% CI: 2.13~4.13, P < 0.00001), the nature of the tissue (OR = 80.30, 95% CI: 29.21~220.81, P < 0.00001), lymph node metastasis (OR = 2.78, 95% CI: 1.23~6.27, P = 0.01), and the cumulative 5-year overall survival rate (OR = 0.54, 95% CI:0.29~0.99, P = 0.05). No significant associations were identified between EpCAM overexpression and gender (OR = 0.89, 95% CI: 0.66~1.19, P = 0.43), age (OR = 1.13, 95% CI: 0.58~2.20, P = 0.73), tumour stage (OR = 2.26, 95% CI: 0.79~6.45, P = 0.13), distant metastasis (OR = 2.15, 95% CI: 0.20~22.69, P = 0.52), TNM stage (OR = 5.14, 95% CI: 0.77~34.37, P = 0.09), Lauren type (OR = 1.18, 95% CI: 0.08~16.45, P = 0.9), differentiation (OR = 1.88, 95% CI: 0.65~5.41, P = 0.24). However, due to significant heterogeneity in tumor stage, lymph node metastasis, TNM stage, differentiation and Lauren type, these results should be taken carefully.ConclusionsThe meta-analysis demonstrated that the expression of EpCAM in the gastric cancer group was greater than that in the control group. Moreover, EpCAM overexpression was associated with larger tumour size, lymphnode metastasis and worse prognosis in gastric cancer. Due to significant heterogeneity, the sensitivity analysis suggests that population factor may be an important source of heterogeneity, and these results should be treated with caution. EpCAM may be useful as a novel prognostic factor, and large-scale and well-designed studies are needed to validate our results in the future.

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“…Previous studies have indicated that GSTP1 polymorphism is associated with various kinds of cancers, such as acute myeloid leukemia, lung cancer, breast cancer, colorectal cancer, brain tumor, and esophageal cancer (Cong et al, 2014;Silva et al, 2014;Song et al, 2014;Jaramillo-Rangel et al, 2015;Nasr et al, 2015;Sharma et al, 2015;Soto-Quintana et al, 2015;Zhou et al, 2015;Geng et al, 2016;Khabaz et al, 2016;Kimi et al, 2016). Several studies have also reported that GSTP1 polymorphism is associated with risk of gastric cancer in various populations, but the results were inconsistent (Nguyen et al, 2010;Zhang et al, 2011;Bao et al, 2012;García-González et al, 2012;Jing et al, 2012;Zhang et al, 2012;Ma et al, 2013). Four studies were carried out in a Chinese population, and significant associations were found between GSTP1 Ile105Val polymorphism and risk of gastric cancer (Bao et al, 2012;Zhang et al, 2012;Ma et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have also reported that GSTP1 polymorphism is associated with risk of gastric cancer in various populations, but the results were inconsistent (Nguyen et al, 2010;Zhang et al, 2011;Bao et al, 2012;García-González et al, 2012;Jing et al, 2012;Zhang et al, 2012;Ma et al, 2013). Four studies were carried out in a Chinese population, and significant associations were found between GSTP1 Ile105Val polymorphism and risk of gastric cancer (Bao et al, 2012;Zhang et al, 2012;Ma et al, 2013). However, several studies conducted in American, Turkish, southEuropean, Vietnamese, as well as Chinese populations have indicated that GSTP1 Ile105Val polymorphism did not play a role in the development of gastric cancer (Nguyen et al, 2010;Zhang et al, 2011;García-González et al, 2012;Jing et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors

2017

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ABSTRACT. Glutathione S-transferase (GST) is an important member of phase II metabolic enzymes; GSTM1, GSTT1, and GSTP1 belong to three subfamilies of the GST enzyme. Polymorphisms in GSTM1, GSTT1, and GSTP1 could affect detoxification processes, and increase individuals' susceptibility to cancers. We aimed to investigate the association between GSTM1, GSTT1, and GSTP1 polymorphisms and the risk of gastric cancer in a Chinese population. In addition, we also examined the effect of gene-environmental interactions, and their effect on risk of this cancer. Between July 2013 and June 2015, we recruited 242 gastric cancer patients and 396 healthy controls for our study. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to characterize genetic polymorphisms in GSTM1, GSTT1, and GSTP1. We observed that the Val/Val genotype of GSTP1 was associated with increased risk of gastric cancer when compared with the Ile/Ile genotype (OR = 3.19, 95%CI = 1.84-5.56). Moreover, the Val allele of GSTP1 was associated with higher susceptibility to gastric cancer as compared with the Ile allele (OR = 1.52, 95%CI = 1.19-1.93). However, GSTM1 and GSTT1 polymorphisms did not affect the development of gastric cancer. In conclusion, our study indicated that GSTP1 Ile105Val, but not GSTM1 and GSTT1 polymorphisms, was associated with risk of gastric cancer.

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Association Between the GSTP1 Codon 105 Polymorphism and Gastric Cancer Risk: an Updated Meta-analysis

Cited by 10 publications

References 33 publications

Glutathione S-transferase P1 Ile105Val Polymorphism and Oral Cancer Risk: A Meta-Analysis

Glutathione S-transferase P1 Ile105Val Polymorphism and Oral Cancer Risk: A Meta-Analysis

Relationship between epithelial cell adhesion molecule (EpCAM) overexpression and gastric cancer patients: A systematic review and meta-analysis

Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors

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