Genetic Polymorphisms in the Vitamin D Pathway and Non-small Cell Lung Cancer Survival

Abstract

Various genetic polymorphisms have been linked to lung cancer susceptibility and survival outcomes. Vitamin D (VD) regulates cell proliferation and differentiation, inhibits tumor growth and induces apoptosis. Observations from several previous studies including our own suggest that genetic polymorphisms in the VD pathway may be associated with lung cancer risk. The aim of this study is to assess if genetic polymorphisms in the VD pathway are associated with the prognosis of non-small cell lung cancer (NSCLC). Nine single nucleotide polymorphisms (SNPs) in five genes in the VD pathway were genotyped with the TaqMan assays in 542 patients with primary NSCLC, and the relationships between these SNPs and overall survival were evaluated. We found that SNP rs10741657 in the CYP2R1 gene was associated with the prognosis of NSCLC, especially in elderly patients and not being treated with chemotherapy. Some of the VD pathway-related genetic polymorphisms may influence the prognosis of NSCLC. More research is needed to further confirm the finding and test if VD supplements can be used for NSCLC treatment.

Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer

“…Survival of lung cancer patients 5 years after diagnosis is between 10% and 20% in most countries, even after surgery, chemotherapy, and radiotherapy [4]. There is therefore a need to look for new prognostic biomarkers that will improve survival in these patients [5]. The main factor influencing disease prognosis is the initial tumor stage [6][7][8].…”

Clinical significance and prognostic value of Porphyromonas gingivalis infection in lung cancer

“…Therefore, it is of great significance to find the factors related to the occurrence, development and metastasis of lung cancer in order to predict its survival and prognosis and provide possible means for treatment. For a long time, the research on lung cancer has mostly focused on the cancer cells themselves, mainly due to changes in gene level [ [18] , [19] – 20 ]. In contrast, there is little discussion about the chronic infection of pathogenic microorganisms.…”

Effect of aerobic exercise on acquired gefitinib resistance in lung adenocarcinoma

“…In the early stage, lung adenocarcinoma usually features the general symptoms of respiratory diseases, which are easily overlooked. Diagnosis usually occurs in the advanced stage, and the prognosis is very poor [ 3 , 4 ]. With advances in medical research, targeted therapy has gradually become a new method of treatment.…”