Genetic polymorphism of myostatin gene in Sumba Ongole (Bos indicus) cattle and its association with growth traits

Gaina, Cynthia Dewi; Amalo, Filphin Adolfin

doi:10.5455/javar.2022.i625

Cited by 5 publications

(3 citation statements)

References 55 publications

(129 reference statements)

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“…It seems that MSTN calves had significant improvement in muscularity traits, as previously described in MSTN -gene-edited cattle [ 29 ]. Recently, Gaina and Amalo [ 46 ] found two SNPs ( c424 and c467 ) of the MSTN gene in (Bos indicus) cattle, which are associated with phenotypes of wither height, heart girth and hip height, but not with body weight or body length.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Some Myostatin Variants and Meat Production Related Calving, Weaning and Muscularity Traits in Charolais Cattle

Csürhés¹,

Szabó

Holló

et al. 2023

Animals

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The slaughter value of live cattle can be assessed during visual conformation scoring, as well as by examining different molecular genetic information, e.g., the myostatin gene, which can be responsible for muscle development. In this study, the F94L, Q204X, nt267, nt324 and nt414 alleles of the myostatin gene (MSTN) were examined in relation to birth weight (BIW), calving ease (CAE), 205-day weaning weight (CWW), muscle score of shoulder (MSS), muscle score of back (MSB), muscle score of thigh (MST), roundness score of thigh (RST), loin thickness score (LTS), and overall muscle development percentage (OMP) of Charolais weaned calves in Hungary. Multi-trait analysis of variance (GLM) and weighted linear regression analysis were used to process the data. Calves carrying the Q204X allele in the heterozygous form achieved approximately 0.14 points higher MSB, MST and LTS, and 1.2% higher OMP, and gained 8.56 kg more CWW than their counterparts not carrying the allele (p < 0.05). As for the F94L allele, there was a difference of 4.08 kg in CWW of the heterozygous animals, but this difference could not be proved statistically. The other alleles had no significant effect on the evaluated traits.

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Section: Discussionmentioning

confidence: 99%

Relationship between Some Myostatin Variants and Meat Production Related Calving, Weaning and Muscularity Traits in Charolais Cattle

Csürhés¹,

Szabó

Holló

et al. 2023

Animals

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“…Manfaat lain dari karakterisasi gen MSTN adalah membantu peternak dalam melakukan seleksi genetik yang baik. Seleksi tersebut bertujuan untuk melihat cattle jenis mana yang memiliki pertumbuhan otot yang baik (Gaina & Amalo, 2022).…”

Section: Dengan Menggunakan Sekuens Dari Ncbi Pada Spesiesunclassified

Analisis Keanekaragaman Gen Myostatin (Mstn) Secara in-Silico Pada Cattle Di Indonesia

Ma'arif,

Hanum Isfaeni,

Gunawan

2023

Bioma

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Cattle is one of the largest livestock products in Indonesia. The purpose of this study was to determine the diversity of the myostatin (MSTN) gene found in several cattle in Indonesia. This research was a descriptive analysis research based on several literature studies. Gene data was taken from the National Center for Biotechnology Information (NCBI). The gene data taken were from several species such as Bos indicus, Bos indicus×Bos taurus, and Bos taurus. Meanwhile, Bubalus bubalis, Capra hircus, and Cervis sp. were selected as outgroups. DNA sequence data analysis was aligned using MEGA XI software. MSTN gene parameters showed results between the kinship of several cattle in Indonesia. From these results it can be found that there were still several species of cattle in Indonesia that were not yet found in the NCBI database on the MSTN gene. For example, Madura cattle (Bos javanicus), PO Kebumen, PO Aceh, and several livestock products that do not yet have the MSTN gene characterization database. Therefore, to improve the quality of beef in Indonesia, it is necessary to characterize the MSTN gene in several species that are not yet in the database as a benchmark for the quality level of cattle in Indonesia.

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“…All of the SNPs in SO cattle (Table 2) have Ho values below 0.5, indicating limited diversity, as reported by Vissers et al (2003). Adaptation efforts by SO cattle to the severe climatic circumstances on Sumba Island are thought to have resulted in the mutation seen in SO cattle as it is stated by (Gaina et al, 2022;Vani et al, 2022). Heterozygosis values are a method of gauging a population's genetic diversity that can inform a selection program's choices (Marson et al, 2005).…”

Section: Heterozygosis Of Bmp 15 Gene and Hardy-weinberg Equilibriummentioning

confidence: 99%

The Potency of the BMP 15 Gene as a Marker of Reproductive Traits in Sumba Ongole (Bos indicus) Cattle

Gaina¹,

Sanam²,

Nalley³

et al. 2023

ASD

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Background: As one of the important genetic resources for Ongole beef cattle, the study aimed to identify any potential polymorphisms in the Bone Morphogenetic Protein 15 gene in a group of Sumba Ongole (SO) cattle. Methods: Blood samples from 161 SO cattle were obtained and examined. The initial stage was the isolation of deoxyribonucleic acid (DNA). The next procedures were electrophoresis and extraction, followed by annealing temperature optimization, amplification and sequencing. The Basic Local Alignment Search Tool (BLAST) was used to examine the sequencing findings. The annealing temperature was 58°C for 15 seconds, with an amplification gain of 350 base pairs (bp). Result: The result showed that there were six single nucleotide polymorphisms (SNPs) of the BMP 15 gene in this region. Six mutations were SNP c.57 G greater than A, SNP c.120 C greater than T, SNP c.338 G greater than T, SNP c.360 C greater than A, SNP c.361 G greater than T, SNP c.365 A greater than T. The polymorphic informative content (PIC) value (0.25 less than =PIC less than =0.5) was reached from low (0.02) to moderate high (0.45 and 0.47). A total of 2 SNPs in the BMP 15 gene with moderate-high PIC value was c.360 C greater than A and c.365 A greater than T. In conclusion, we reported for the first time the polymorphism of the BMP 15 gene which is required for further investigation as to whether this polymorphic could be responsible for reproductive trait variations in Ongole cattle.

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Genetic polymorphism of myostatin gene in Sumba Ongole (Bos indicus) cattle and its association with growth traits

Cited by 5 publications

References 55 publications

Relationship between Some Myostatin Variants and Meat Production Related Calving, Weaning and Muscularity Traits in Charolais Cattle

Relationship between Some Myostatin Variants and Meat Production Related Calving, Weaning and Muscularity Traits in Charolais Cattle

Analisis Keanekaragaman Gen Myostatin (Mstn) Secara in-Silico Pada Cattle Di Indonesia

The Potency of the BMP 15 Gene as a Marker of Reproductive Traits in Sumba Ongole (Bos indicus) Cattle

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