Genetic polymorphism in ornithine decarboxylase and risk of breast cancer

Brown, Iain; Halliday, S E; Greig, Heather; Heys, Steven Darryll; Wallace, Heather M.; Schofield, Andrew Craig

doi:10.1007/s10689-009-9237-9

Cited by 9 publications

(7 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, only individuals carrying heterozygous genotypes have a decrease for the risk of hepatocellular carcinoma development in our study. Such situation is not usual but is observed in some investigations of other cancers, such as esophageal squamous cell carcinoma [27], pancreatic cancer [28], and breast cancer [29], [30]. Gene coding sequences account for only 1.5% of the human genome.…”

Section: Discussionmentioning

confidence: 97%

Single Nucleotide Polymorphisms of Toll-Like Receptor 4 Decrease the Risk of Development of Hepatocellular Carcinoma

Shi

Chen

et al. 2011

PLoS ONE

View full text Add to dashboard Cite

BackgroundToll-like receptor 4 (TLR4) is a key innate immunity receptor that initiates an inflammatory response. Growing evidence suggests that mutation of TLR4 gene may play a role in the development of cancers. This study aimed to investigate the temporal relationship of single nucleotide polymorphisms of TLR4 and the risk of hepatocellular carcinoma, a single center-based case-control study was conducted.MethodsA systematic genetic analysis of sequence variants of TLR4 by evaluating ten single-nucleotide polymorphisms was performed from 216 hepatocellular carcinoma cases and 228 controls.ResultsSix single nucleotide polymorphisms of the TLR4 in the 5′-untranslated region and intron were associated with risk of hepatocellular carcinoma. Individuals carrying the heterozygous genotypes for the rs10759930, rs2737190, rs10116253, rs1927914, rs12377632 and rs1927911 had significantly decreased risk of hepatocellular carcinoma (adjusted odds ratio [OR], from 0.527 to 0.578, P<0.01) comparing with those carrying wild-type homozygous genotypes. In haplotype analysis, one haplotype (GCCCTTAG) of TLR4 was associated significantly with decrease of the occurrence of hepatocellular carcinoma (OR, 0.556, 95% confidence interval [CI], 0.407–0.758, P = 0.000).ConclusionsCollectively, these results suggested that the risk of hepatocellular carcinoma was associated with TLR4 sequence variation. TLR4 single nucleotide polymorphisms may play an important protective role in the development of hepatocellular carcinoma.

show abstract

Section: Discussionmentioning

confidence: 97%

Single Nucleotide Polymorphisms of Toll-Like Receptor 4 Decrease the Risk of Development of Hepatocellular Carcinoma

Shi

Chen

et al. 2011

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…In 2009, Brown et al (31) reported that the ODC G316A polymorphism (SNP no. rs2302615) may be less important in individuals with an inherited predisposition for breast cancer than in individuals who develop sporadic breast cancer (32).…”

Section: Discussionmentioning

confidence: 99%

Association between the ornithine decarboxylase G316A polymorphism and breast cancer survival

Long

Wang

et al. 2015

Oncology Letters

View full text Add to dashboard Cite

Abstract. Ornithine decarboxylase (ODC) is a significant rate-limiting enzyme in polyamine synthesis, required for normal cell growth, and is highly expressed in various malignancies, including colorectal and breast cancer. In the present study, the associations between the ODC G316A single nucleotide polymorphism (SNP) and breast cancer-specific survival were investigated. In addition, the functional effects of this SNP were examined in the MCF-7 human breast cancer cell line. The present study recruited 300 stage I-III breast cancer cases, which were diagnosed at

show abstract

“…The findings from this study reveal that the ODC gene +316 G/A and SAT-1 gene 1415 T/C polymorphisms cannot serve as candidate genetic markers for screening the causes of stone disease as the frequency of distribution in SNPs was similar in urolithiasis when compared with the disease-free control group. A recent study has shown that ODC >316 G/A polymorphism (rs2302615) was associated with the progression of sporadic breast cancer and that the presence of one copy of A allele has a protective role in the prevention of the disease (29).…”

Section: Discussionmentioning

confidence: 99%

Lack of evidence for the association of ornithine decarboxylase (+316 G>A), spermidine/spermine acetyl transferase (−1415 T>C) gene polymorphisms with calcium oxalate stone disease

Gürkan

Arısan

et al. 2013

Biomedical Reports

View full text Add to dashboard Cite

Urolithiasis is a complex and multifactorial disorder characterized by the presence of stones in the urinary tract. Urea cycle is an important process involved in disease progression. L-ornithine is a key amino acid in the urea cycle and is converted to putrescine by ornithine decarboxylase (ODC). Putrescine, spermidine and spermine are natural polyamines that are catabolized by a specific enzyme, spermidine/spermine acetyltransferase (SSAT). The single-nucleotide polymorphisms (SNPs) in the intron region of ODC (+316 G>A) and promoter region of SSAT (-1415 T>C) genes have been found to be associated with the polyamines expression levels. The aim of this study was to examine whether the ODC (+316 G>A) intron 1 region gene polymorphism and SAT-1 promoter region (-1415 T>C) gene polymorphisms are potential genetic markers for susceptibility to urolithiasis. A control group of 104 healthy subjects and a group of 65 patients with recurrent idiopathic calcium oxalate stone disease were enrolled into this study. Polymerase chain reaction (PCR)-based restriction analysis was performed for the ODC intron 1 (+316 G>A) region and SAT-1 (-1415 T>C) promoter gene polymorphisms by I andI restriction enzyme digestion, respectively. The genotype distribution of polymorphisms studied in the ODC intron 1 region (+316 G>A) and SAT-1 -1415 T>C promoter region did not reveal a significant difference between urolithiasis and the control groups (P=0.713 and 0.853), respectively. Furthermore, no significant difference was observed between the control and patient groups for ODC +316 G>A and SAT-1 -1415 T>C allele frequencies (P=0.877 and 0.644), respectively. In conclusion, results of the present study suggest that ODC + 316 G>A and SAT-1 -1415 T>C gene polymorphisms might not be a risk factor for urolithiasis.

show abstract

Genetic polymorphism in ornithine decarboxylase and risk of breast cancer

Cited by 9 publications

References 17 publications

Single Nucleotide Polymorphisms of Toll-Like Receptor 4 Decrease the Risk of Development of Hepatocellular Carcinoma

Single Nucleotide Polymorphisms of Toll-Like Receptor 4 Decrease the Risk of Development of Hepatocellular Carcinoma

Association between the ornithine decarboxylase G316A polymorphism and breast cancer survival

Lack of evidence for the association of ornithine decarboxylase (+316 G>A), spermidine/spermine acetyl transferase (−1415 T>C) gene polymorphisms with calcium oxalate stone disease

Contact Info

Product

Resources

About