Genetic identification of AChE as a positive modulator of addiction to the psychostimulant D-amphetamine in zebrafish

Ninkovic, Jovica; Folchert, Anja; Makhankov, Yuri V.; Neuhauss, Stephan C.F.; Sillaber, Inge; Strähle, Uwe; Bally‐Cuif, Laure

doi:10.1002/neu.20231

Cited by 96 publications

(79 citation statements)

References 44 publications

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“…These properties have established the zebrafish as an excellent model system that is relevant to studies of human diseases (Grunwald and Eisen, 2002). Zebrafish have also become the focus of neurobehavioral studies since larvae display learning, memory, sleep, drug addiction, and behavior phenotypes that are quantifiable and related to those seen in man (Zhdanova et al, 2001;Cahill, 2002;Guo, 2004;Orger et al, 2004;Ninkovic et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Non-Associative Learning in Larval Zebrafish

Best¹,

Berghmans²,

Hunt³

et al. 2007

Neuropsychopharmacol

211

150

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Habituation, where a response is reduced when exposed to a continuous stimulus is one of the simplest forms of non-associative learning and has been shown in a number of organisms from sea slugs to rodents. However, very little has been reported in the zebrafish, a model that is gaining popularity for high-throughput compound screens. Furthermore, since most of the studies involving learning and memory in zebrafish have been conducted in adults, we sought to determine if zebrafish larvae could display non-associative learning and whether it could be modulated by compounds identified in previous rodent studies. We demonstrated that zebrafish larvae (7 days post fertilization) exhibit iterative reduction in a startle response to a series of acoustic stimuli. Furthermore, this reduction satisfied criteria for habituation: spontaneous recovery, more rapid reductions in startle to shorter intertrial intervals and dishabituation. We then investigated the pathways mediating this behavior using established compounds in learning and memory. Administration of rolipram (PDE4 inhibitor), donepezil (acetylcholinesterase inhibitor), and memantine (N-methyl-D-aspartic acid (NMDA) receptor antagonist) all increased the acoustic startle response and decreased habituation in the larvae, similar to previous rodent studies. Further studies demonstrated that NMDA blocked the memantine response and the effect of donepezil was blocked by mecamylamine but not atropine suggesting that the donepezil response was mediated by nicotinic rather than muscarinic receptors. Zebrafish larvae possess numerous advantages for medium to high-throughput screening; the model described herein therefore offers the potential to screen for additional compounds for further study on cognition function.

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Section: Introductionmentioning

confidence: 99%

Non-Associative Learning in Larval Zebrafish

Best¹,

Berghmans²,

Hunt³

et al. 2007

Neuropsychopharmacol

211

150

View full text Add to dashboard Cite

show abstract

“…Among vertebrates, the zebrafish model appears to be well suited for such investigation, being responsive to the developmental [36] and rewarding effects [37][38][39] of drugs of abuse. This model provides unique opportunities for studying the genetic bases of drug-related phenomena [40].…”

Section: Introductionmentioning

confidence: 99%

Gender differences in zebrafish responses to cocaine withdrawal

López‐Patiño

Yamamoto

et al. 2008

Physiology & Behavior

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The acute responses to cocaine and its withdrawal contribute to cocaine dependence and potentiate relapse, with gender being one of the genetic factors affecting the outcome. Here we report that in both male and female zebrafish (Danio rerio, AB strain), an initial low-dose cocaine treatment (1.5μM, immersion) does not acutely change their behavior. The cocaine withdrawal, however, is associated with an anxiety-like state that develops earlier in female zebrafish but is more robust and persistent in males, and can be acutely attenuated by cocaine administration. This is not a result of gender differences in the expression of anxiety-like state, since behavioral responses to an anxiogenic drug, FG-7142, are similar in male and female zebrafish. The basal brain dopamine (DA) levels and the expression of dopamine transporter mRNA (zDAT) show no significant sexual dimorphism. Acute cocaine exposure does not significantly change DA or zDAT. Withdrawal from repeated cocaine administration results in an overall reduction in zDAT, as well as an increase in DA levels. Neither treatment leads to significant gender differences in brain DA or zDAT. The common and gender-specific effects of cocaine on zebrafish, a well-characterized model of vertebrate development and genetics, should help in understanding the mechanisms involved in the anxiety associated with cocaine withdrawal and provide new opportunities in search for therapeutic solutions.

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“…Place preference: The tendency to establish a preferred location in which the fish spends more time. Can be induced by drugs (e.g., in conditioned place preference paradigms, CPP 9,123,[135][136][137][138][139] ), repeated administration of food/food odors, 73 social reward, 13 or be based on natural behaviors (e.g., homebase formation 113 ) or preferences (e.g., depth preference, scototaxis, thigmotaxis 31,59,60 ). 1.120.…”

mentioning

confidence: 99%

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

et al. 2013

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Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and behavioral research. Physiological similarity to mammals, ease of genetic manipulations, sensitivity to pharmacological and genetic factors, robust behavior, low cost, and potential for high-throughput screening contribute to the growing utility of zebrafish models in this field. Understanding zebrafish behavioral phenotypes provides important insights into neural pathways, physiological biomarkers, and genetic underpinnings of normal and pathological brain function. Novel zebrafish paradigms continue to appear with an encouraging pace, thus necessitating a consistent terminology and improved understanding of the behavioral repertoire. What can zebrafish 'do', and how does their altered brain function translate into behavioral actions? To help address these questions, we have developed a detailed catalog of zebrafish behaviors (Zebrafish Behavior Catalog, ZBC) that covers both larval and adult models. Representing a beginning of creating a more comprehensive ethogram of zebrafish behavior, this effort will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebrafish neurobehavioral paradigms in their research. In addition, this glossary creates a framework for developing a zebrafish neurobehavioral ontology, ultimately to become part of a unified animal neurobehavioral ontology, which collectively will contribute to better integration of biological data within and across species.

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Genetic identification of AChE as a positive modulator of addiction to the psychostimulant D-amphetamine in zebrafish

Cited by 96 publications

References 44 publications

Non-Associative Learning in Larval Zebrafish

Non-Associative Learning in Larval Zebrafish

Gender differences in zebrafish responses to cocaine withdrawal

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

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