“…Several disease-related genes have been mapped to chromosome band 1q21, including the GLC1A locus for open-angle glaucoma (Brezin et al, 1997), the familial partial lipodystrophy locus (Peters et al, 1998), a target binding site for the Wilms' tumor suppressor 1 (WT1) gene (Negus et al, 1996), genes linked to hyperparathyroidism (Teh et al, 1996), nonsyndromic hearing impairment (Fagerheim et al, 1996), neural tube defects (Stanier et al, 1995), and multiple craniofacial anomalies (Leichtman et al, 1993). Nonrandom abnormalities of 1q21 → q25 are frequent in AIDS-related Burkitt's lymphoma-derived cell lines (Polito et al, 1995), and there is an overrepresentation of 1q21 → q23 in lipoma-like and soft-tissue sarcomas (Forus et al, 1995;Szymanska et al, 1997).…”