Genetic Control of Oxytetracycline Biosynthesis

Alikhanian, S. I.; Орлова, Н. В.; Mindlin, S. Z.; Zaitzeva, Z. M.

doi:10.1038/189939b0

Cited by 11 publications

(3 citation statements)

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“…From this time and until the late 1960s, almost all research on S. rimosus genetics concentrated on the following four areas: (i) isolation of nutritional and non-OTC-producing mutants, (ii) classification of the latter using the principle of cosynthesis on solid media, (iii) development of mapping procedures by selective and heteroclone analysis, and (iv) establishment of linkage between mutations by conjugation (6,14,15,17,32,33,54,67,155,156,157,159). During this initial period, interspecific recombination among tetracycline-producing streptomycetes, as well as recombination with some more distantly related species, was also reported (5,11,187).…”

Section: Introductionmentioning

confidence: 99%

Genetics ofStreptomyces rimosus, the Oxytetracycline Producer

Petković

Cullum

Hranueli

et al. 2006

Microbiol Mol Biol Rev

101

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SUMMARY From a genetic standpoint, Streptomyces rimosus is arguably the best-characterized industrial streptomycete as the producer of oxytetracycline and other tetracycline antibiotics. Although resistance to these antibiotics has reduced their clinical use in recent years, tetracyclines have an increasing role in the treatment of emerging infections and noninfective diseases. Procedures for in vivo and in vitro genetic manipulations in S. rimosus have been developed since the 1950s and applied to study the genetic instability of S. rimosus strains and for the molecular cloning and characterization of genes involved in oxytetracycline biosynthesis. Recent advances in the methodology of genome sequencing bring the realistic prospect of obtaining the genome sequence of S. rimosus in the near term.

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Section: Introductionmentioning

confidence: 99%

Genetics ofStreptomyces rimosus, the Oxytetracycline Producer

Petković

Cullum

Hranueli

et al. 2006

Microbiol Mol Biol Rev

101

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“…aureofaciens (Délie et al, 1969) and S. rimosus (Alikhanian et al, 1961), which synthesize tetracyclines. Intermediates which accumulate in the blocked mutants diffuse out of the cell and are used by mutants blocked earlier in the pathway.…”

Section: Blocked Mutants and Product Cosynthesismentioning

confidence: 99%

Microbial Culture Selection

Elander¹,

Chang²

1979

Microbial Technology

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“…penicillin biosynthesis (Bonner, 1947), but without much success. Alikhanian, Orlova, Mindlin & Zaitzeva (1961) reported some positive results in resolving the biosynthesis of oxytetracycline by this technique. The main obstacle inherent in this type of approach is the lack of sufficient information concerning the life cycle of many of the organisms producing antibiotics.…”

mentioning

confidence: 99%

A Rapid Method for Isolating Mutants of Bacillus subtilis Producing Increased or Decreased Amounts of the Antibiotic, Mycobacillin

Banerjee¹,

Bose²

1964

Journal of Applied Bacteriology

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Summary: A simple, rapid and efficient technique is described for the isolation of mutants of Bacillus subtilis in which the synthesis of mycobacillin, an antifungal antibiotic, is blocked. Suspensions of a chosen culture were subjected to ultraviolet radiation and then plated; colonies failing to produce antibiotic were located by flooding the incubated plates with agar seeded with sensitive fungi such as Candida albicans and Aspergillus niger. The method is also applicable for the isolation of high potency strains.

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Genetic Control of Oxytetracycline Biosynthesis

Cited by 11 publications

References 0 publications

Genetics ofStreptomyces rimosus, the Oxytetracycline Producer

Genetics ofStreptomyces rimosus, the Oxytetracycline Producer

Microbial Culture Selection

A Rapid Method for Isolating Mutants of Bacillus subtilis Producing Increased or Decreased Amounts of the Antibiotic, Mycobacillin

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