Microbial Culture Selection

Elander, R. P.; Chang, L. T.

doi:10.1016/b978-0-12-551502-3.50017-7

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Selection Of Mutants For Resistance To Toxic Antibiotic Prec1

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1983

1997

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Cited by 5 publications

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“…Native resistance of most fungi to commonly used analogs is well documented (LEMKE 1969;LEMKE and BRANNON 1972). Since penicillins and cephalosporins are derived from oc-aminoadipic acid, cysteine, and valine, it was suggested that deregulation of these amino acid pathways might lead to the selection of superior strains (DREW and DEMAIN 1977;DE-MAIN and MASUREKAR 1974;ELANDER and CHANG 1979). Recently, MEHTA and NASH (1979) showed that the relationship between the carbon source in test media markedly influenced the toxicity of a number of amino acid analogues in a highproducing strain of A. chrysogenum.…”

Section: Selection Of Mutants For Resistance To Toxic Antibiotic Precmentioning

confidence: 98%