Genetic Association of Interleukin-4, Interleukin-10, and Transforming Growth Factor-β Gene Polymorphism With Allograft Function in Renal Transplant Patients

Amirzargar, Mohammad Ali; Yavangi, Mahnaz; Basiri, Abbas; Moghadam, S.H.; Khosravi, Farideh; Solgi, Ghasem; Gholiaf, Mahmood; Khoshkho, F.; Dadaras, F.; Mahmmodi, M.; Ansaripour, Bita; Amirzargar, Aliakbar; Nikbin, Behrouz

doi:10.1016/j.transproceed.2007.03.054

Cited by 19 publications

(14 citation statements)

References 16 publications

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“…Increased serum levels of inflammatory cytokines including interleukin (IL)-18 [8], IL-6 [9], IFN-γ [7], IL-17 [7], and TNF-α [9] have been documented in T2D and its nephropathic complications. Furthermore, the association of IL-10 in immunological disorders such as multiple sclerosis [10], systemic lupus erythematosus [11], nephrotic syndrome [12], graft rejection [13], asthma [14], and type 1 [15] diabetes is well established.…”

Section: Introductionmentioning

confidence: 99%

Interleukin (IL)-10 Gene Polymorphisms Are Associated with Type 2 Diabetes With and Without Nephropathy: A Study of Patients from the Southeast Region of Iran

et al. 2011

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The impact of several environmental and genetic factors on diabetes and its complications is well documented. It has also been established that cytokines play a key role in the regulation of immune responses which have been shown to be important in the pathogenesis of diabetes. Studies showed that single-nucleotide polymorphisms within the -592 region of interleukin-10 (IL-10) are associated with the regulation of its expression. In this study, we aimed to find polymorphisms of this region that may be associated to type 2 diabetic (T2D) patients with and without nephropathy. In this study, peripheral blood samples were collected from 100 T2D patients without nephropathy, 100 T2D patients with nephropathy, and 100 healthy controls. DNA was extracted, and a polymerase chain reaction-restriction fragment length polymorphism technique was performed to examine the polymorphisms within the -592 region of the IL-10 gene. Our results showed a significant difference between the genotypes and alleles of the -592 region of IL-10 in nephropathic and non-nephropathic patients in comparison to the healthy controls. The differences between the two patient groups in relation to genotypes and alleles were not significant. Results of this study suggest that the functional gene polymorphism of IL-10 reported here may play an important role in the pathogenesis of diabetes, but it seems that these polymorphisms do not have an effect on the nephropathic complications of the disease.

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Section: Introductionmentioning

confidence: 99%

Interleukin (IL)-10 Gene Polymorphisms Are Associated with Type 2 Diabetes With and Without Nephropathy: A Study of Patients from the Southeast Region of Iran

et al. 2011

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“…It has been found that TGF-β production varies from person to person and is partly dependent on the different TGF-β gene polymorphisms. TGF-β pathway was described to modulate the development of several disease groups, including cancer, atherosclerosis, autoimmune and also fibrotic disease [2,5]. Our results indicate a higher percentage of homozygosity of the polymorphic C allele in the codon 25 of the TGF-β gene in the control group, while the G→C alteration in codon 25 (rs1800471) is associated with lower pro-duction of TGF-β.…”

Section: Discussionmentioning

confidence: 55%

Predictive Role of Cytokine Gene Polymorphisms for the Development of Femoral Head Osteonecrosis

Samara¹,

Kollia

Dailiana³

et al. 2012

Disease Markers

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Introduction: Osteonecrosis (ON) is a multifactorial disease that leads to hip destruction. Lately, much focus has been at femoral head preservation with nonsurgical methods. In this study we examined the polymorphisms of IL-1α, IL-1R, IL-1RA, IL-4Rα, IL-1β, IL-12,γIFN, TGF-β, TNF-a, IL-2, IL-4, IL-6 and IL-10 genes for evaluation of their contribution in ON.Material and methods: DNA was extracted from 112 ON patients and 438 healthy donors. Analysis of the polymorphisms was completed using the PCR-SSP method. Statistical analysis was performed using theχ2test to compare the genotype and allelic frequency distribution.Results: The CT and GA genotypes of the IL-1α(-889) and TNF-a (-238) genes were found higher in the patients (51.8% and 10.8%, respectively) compared to the healthy donors (39.7% and 2.1%, respectively). In TGF-βcodon 25, the G to C polymorphism in the homozygous state was found in 1.8% of the patients and the C allele frequency was 8.9%, whereas the G allele frequency was 91.1%. Also, at the IL-10 (-1082) gene the GG genotype was 16.2% in the controls whereas in the patients was 7.2%.Conclusions: Based on the above, we showed that certain genotypes of the IL-1α, TGF-β, IL-10 and TNF-a genes could be related in the pathogenesis of a complicated disease, such as osteonecrosis. The presence of one of the above mentioned polymorphisms or the simultaneous carriage of more than one may further increase the risk for osteonecrosis, especially in those at high risk, such as patients receiving corticosteroids.

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“…IL-4 blocks macrophage activation and inhibits the production of Th1 cytokines such as IL-1 and tumor necrosis factor-␣ [1,18,38]. Several studies have investigated the risk of recipient IL4 polymorphisms on acute rejection of allografts in kidney or heart transplantation [1,[8][9][10][16][17][18]. The TT genotype of IL4-33 is reported to be associated with high production of IL-4 [4,15].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have investigated the risk of recipient IL4 gene polymorphisms in acute rejection of allografts [1,[8][9][10]16,17]. In addition, studies have assessed the association of donor IL4 polymorphisms and acute rejection of solid organ allografts [9,10,17,18].…”

Section: Introductionmentioning

confidence: 99%

Association of interleukin4 gene polymorphisms of recipients and donors with acute rejection following living donor liver transplantation

Kamei

Masuda

Ishigami

et al. 2016

Clinics and Research in Hepatology and Gastroenterology

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Genetic Association of Interleukin-4, Interleukin-10, and Transforming Growth Factor-β Gene Polymorphism With Allograft Function in Renal Transplant Patients

Cited by 19 publications

References 16 publications

Interleukin (IL)-10 Gene Polymorphisms Are Associated with Type 2 Diabetes With and Without Nephropathy: A Study of Patients from the Southeast Region of Iran

Interleukin (IL)-10 Gene Polymorphisms Are Associated with Type 2 Diabetes With and Without Nephropathy: A Study of Patients from the Southeast Region of Iran

Predictive Role of Cytokine Gene Polymorphisms for the Development of Femoral Head Osteonecrosis

Association of interleukin4 gene polymorphisms of recipients and donors with acute rejection following living donor liver transplantation

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