Genetic and Environmental Factors in Autism

Güney, Esra; İşeri, Elvan

doi:10.5772/53295

Cited by 6 publications

(3 citation statements)

References 146 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Autism Spectrum Disorder (ASD) characterized by deficits in social communication, social interaction, and restricted repetitive behaviors, interests, and activities, was previously described as five distinct disorders (American Psychiatric Association, 2013). It has intertwined genetic, environment, neurobiologic causes (Guney & Iseri, 2013). 1 in 160 children worldwide has Autism Spectrum Disorder (WHO, 2019).…”

Section: Introductionmentioning

confidence: 99%

Parent-initiated Health and Education Services for Children with Autism in Baguio, Philippines

Gattud

Piduca

2020

IJDS

View full text Add to dashboard Cite

Autism requires individualized services to maximize full and effective participation in society. Legal mandates facilitate the coordination of health and education services for children with autism. Descriptive correlation was utilized to describe the health and education services initiated by the parents of children with autism in an urban locality in the Philippines, which has no legal framework for services specific to them. Likert-type questionnaires gathered data from purposively sampled respondents. There is selective utilization of health and education services for children with autism. The parent's number of children, income, and level of education significantly varied how they perceived educational programs and health services. Different aspects of educational services correlated with the availed health services. Accessibility and availability of health and educational services for these children must be improved. Further study on health and education services' impact on children with disabilities at different levels of education and health care system is needed.

show abstract

Section: Introductionmentioning

confidence: 99%

Parent-initiated Health and Education Services for Children with Autism in Baguio, Philippines

Gattud

Piduca

2020

IJDS

View full text Add to dashboard Cite

show abstract

“…The typical ASD symptoms approved by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), include social communication/interaction disability, repetitive behaviors, and sensory impairments [2]. Genetic and environmen-tal factors have also a considerable role in this heterologous disorder [3]. Many related etiological factors such as mitochondrial dysfunction [4], heart rate [5], Zn/Cu levels [6], and serotonin system [7], have been suggested for the given disorder.…”

Section: Introductionmentioning

confidence: 99%

Identification of the Key Genes of Autism Spectrum Disorder Through Protein-Protein Interaction Network

Zamanian Azodi,

Rezaei-Tavirani,

Rezaei-Tavirani

2019

GMJ

View full text Add to dashboard Cite

Background: Currently, the prevalence of autism spectrum disorder (ASD) is increasing, which widely spurs the interest in the molecular investigation. Thereby, a better understanding of the given disorder mechanisms is likely to be achieved. Bioinformatics suiting protein-protein interactions analysis via the application of high-throughput studies, such as protein array, is one of these achievements.Materials and Methods: The gene expression data from Gene Expression Omnibus (GEO) database were downloaded, and the expression profile of patients with developmental delay and autistic features were analyzed via Cytoscape and its relevant plug-ins.Results: Our findings indicated that EGFR, ACTB, RHOA, CALM1, MAPK1, and JUN genes as the hub-bottlenecks and their related terms could be important in ASD risk. In other words, any expression modification in these genes could trigger dysfunctions in the corresponding biological processes.Conclusion: We suggest that differentially expressed genes could be used as suitable targets for ASD after being validated.[GMJ.2019;8:e1367]

show abstract

“…More over it is possible that individual vulnerability to toxic environmental exposure varies according to additive and interactive effects of multiple genetics, and poly morphisms that negatively affect detoxification capacity (Lichtens et al, 2010). Because the risk of developmental toxicity with low dose environmental chemicals is likely to be influenced by individual genetic determination of susceptibility (Gurney and Isere, 2013), it was of interest to evaluate autistic children for the frequency of polymorphic variants that affect the tissue distribution and toxicity of mercury (Bernard et al, 2002;Blanchard et al, 2006 andWindham et al, 2006).…”

mentioning

confidence: 99%

Genetic and Environmental Influences on Autism

salama

Mohamed

Youssef

et al. 2017

Journal of Environmental Science

View full text Add to dashboard Cite

Polymorphisms of genes encoding enzymes involved in float metabolism have long been hypothesized to be maternal risk factors for autism. In addition to genetic background, the exposure to mercury whether organic or inorganic can give rise to the symptoms of autism spectrum disorders (ASD) such as impairments in social interaction, communication difficulties and repetitive behaviors and interests. Our objective was to investigate the association between metallothionein (MT) gene polymorphism and levels of mercury in the hair of Egyptian autistic children. Thirty-one autistic children diagnosed by DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4 th Edition criteria) were subjected to hair mercury measurement using Atomic Absorption Spectrometry (AAS) and were compared to polymorphism of genes MT1A and MT1E matched healthy children. The present study revealed that there was a highly significant increase in the mean hair mercury level in autistic patients than controls (0.79±0.56) ppm vs. (0.13±0.08) P<0.001 associated with polymorphism in MT1A (AG genotype). There was high significant difference in MT1E (GG genotype) between males and females (P<0.001) while in control were non significant.The results of this study highly support the increase in the mean hair mercury level in autistic children compared to controls.

show abstract

Genetic and Environmental Factors in Autism

Abstract: Autistic disorder is a multifactorial genetic disorder not following classical Mendelian inheritance. Impairment in social interaction and verbal communication as well as genetic differentiation in rigid-repetitive behaviours indicates that different features in autistic disorder

Cited by 6 publications

References 146 publications

Parent-initiated Health and Education Services for Children with Autism in Baguio, Philippines

Parent-initiated Health and Education Services for Children with Autism in Baguio, Philippines

Identification of the Key Genes of Autism Spectrum Disorder Through Protein-Protein Interaction Network

Genetic and Environmental Influences on Autism

Contact Info

Product

Resources

About