Genetic Analysis of ABO and Rh Blood Groups in Brahmin Population of Uttar Pradesh, India”

Rai, Vandana

doi:10.1038/npre.2011.5931.1

Cited by 4 publications

(6 citation statements)

References 3 publications

(3 reference statements)

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“…Blood group B is most common blood group followed by blood group O, whereas blood group AB is least common among the populations of Eastern Uttar Pradesh region. To test if our sampling had covered the representative blood group distribution of this region, we referred to the published data of the same region [36][37][38][39][40][41][42][43] and performed a regression analysis. The adjusted R square value (83.6 % +3.4 %) demonstrated significantly high level of correlation between our data as well as published data, suggesting that our sampling indeed represented the regional distribution of the blood groups.…”

Section: Resultsmentioning

confidence: 99%

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The association of ABO blood group with the asymptomatic COVID-19 cases in India

Singh

Srivastava²,

Upadhyay

et al. 2021

Transfusion and Apheresis Science

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The COVID-19 pandemic resulted in multiple waves of infection worldwide. The large variations in case fatality rate among different geographical regions suggest that the human susceptibility against this virus varies substantially. Several studies from different parts of the world showed a significant association of ABO blood group and COVID-19 susceptibility. It was demonstrated that individuals with blood group O are at the lower risk of coronavirus infection. To establish the association of ABO blood group in SARS-CoV-2 susceptibility, we for the first time analysed SARS-CoV-2 neutralising antibodies among 509 individuals, collected from three major districts of Eastern Uttar Pradesh region of India. Interestingly, we found neutralising antibodies in a significantly higher percentage of people with blood group AB (0.36) followed by B (0.31), A (0.22) and lowest in people with blood group O (0.11). We further estimated that people with blood group AB are at comparatively higher risk of infection than other blood groups. Thus, among the asymptomatic SARS-CoV-2 recovered people blood group AB has highest, whilst individuals with blood group O has lowest risk of infection.

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Section: Resultsmentioning

confidence: 99%

“…1). We have also collected blood group data of the same region for comparison from published sources [36][37][38][39][40][41][42][43].…”

Section: Methodsmentioning

confidence: 99%

The association of ABO blood group with the asymptomatic COVID-19 cases in India

Singh

Srivastava²,

Upadhyay

et al. 2021

Transfusion and Apheresis Science

Self Cite

View full text Add to dashboard Cite

show abstract

“…Blood group B is most common blood group followed by blood group O, whereas blood group AB is least common among the populations of Eastern Uttar Pradesh region. To test if our sampling covered a true blood group distribution of this region, we have collected the published data of the same region 33–40 and performed a regression analysis. The adjusted R square value (96.7% ±2.7%) showed a significantly high level of correlation between our data as well as published data, suggesting that our sampling indeed captured the regional distribution of the blood groups.…”

Section: Resultsmentioning

confidence: 99%

“…The frequency bar plot of each blood group was drawn with 95% CI (Figure 1). We have also collected blood group data of the same region for comparison from published sources 33–40 .…”

Section: Methodsmentioning

confidence: 99%

The association of ABO blood group with the asymptomatic COVID-19 cases in India

Singh

Srivastava²,

Upadhyay

et al. 2021

Preprint

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The COVID-19 pandemic has resulted several waves of infection in many countries worldwide. The large variations in case fatality ratio among different geographical regions suggests that the human susceptibility against this virus varies substantially. Several studies from different parts of the world showed a significant association of ABO blood group and COVID-19 susceptibility. It was shown that individuals with blood group O are at the lower risk of coronavirus infection. To establish the association of ABO blood group in SARS-CoV-2 susceptibility, we for the first time analysed SARS-CoV-2 neutralising antibodies as well as blood groups among 509 random individuals from three major districts of Eastern Uttar Pradesh region of India. . Interestingly, we found neutralising antibodies in significantly higher percentage of people with blood group AB (0.36) followed by B (0.31), A (0.22) and lowest in people with blood group O (0.11). This indicates that people with blood group AB are at comparatively higher risk of infection than other blood groups. Further, in line to previous reports we too observed that people with blood group O have significantly decreased risk of SARS-CoV-2 infection. Thus, among the asymptomatic SARS-CoV-2 infected individuals with blood group AB has highest, whilst blood group O has lowest risk of infection.

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“…A community-based study in a tribal population of Odisha, where malaria is endemic, also showed higher prevalence of blood group 'O' [25]. Significantly, a lower prevalence 'O' blood group has been observed in other malaria non-endemic states like Maharashtra [26,27] and Uttar Pradesh [28] in India, indicating a selective advantage of this blood group in endemic localities. This hypothesis is further supported by higher prevalence of 'O' blood group worldwide where malaria infection is prevalent [29].…”

Section: Discussionmentioning

confidence: 99%

Association of ABO blood group with severe falciparum malaria in adults: case control study and meta-analysis

Panda

Sahu

et al. 2011

Malar J

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BackgroundErythrocyte-associated antigenic polymorphisms or their absence have perhaps evolved in the human population to protect against malarial infection. Studies in various populations consistently demonstrate that blood group 'O' confers resistance against severe falciparum infection. In India, Odisha state has one of the highest incidences of Plasmodium falciparum infection and contributes to the highest number of deaths by falciparum malaria. This study aims to evaluate the relationship between ABO blood group and severe malaria in an adult population at the tertiary care centre in Odisha.MethodsA total of 353 P. falciparum infected subjects and 174 healthy controls were screened for ABO blood group. Falciparum-infected individuals were categorized as severe malaria and uncomplicated malaria. Severe malaria was further clinically phenotyped into cerebral malaria, non-cerebral severe malaria and multi-organ dysfunction. A meta-analysis was performed to assess the role of ABO blood group in severe malaria.ResultsFrequency of blood group 'B' was significantly higher in patients with severe malaria compared to the uncomplicated cases (P < 0.0001; OR = 4.09) and healthy controls (P < 0.0001; OR = 2.79). Irrespective of the level of clinical severity, blood group 'B' was significantly associated with cerebral malaria (P < 0.0001; OR = 5.95), multi-organ dysfunction (P < 0.0001; OR = 4.81) and non-cerebral severe malaria patients (P = 0.001; OR = 3.02) compared to the uncomplicated category. Prevalence of 'O' group in uncomplicated malaria (P < 0.0001; OR = 2.81) and healthy controls (P = 0.0003; OR = 2.16) was significantly high compared to severe malaria. Meta-analysis of previous studies, including the current one, highlighted the protective nature of blood group 'O' to severe malaria (P = 0.01). On the other hand, carriers of blood group 'A' (P = 0.04) and 'AB' (P = 0.04) were susceptible to malaria severity.ConclusionsResults of the current study indicate that blood group 'O' is associated with reduced and 'B' blood group with increased risk of development of severe malaria in Odisha, India. Meta-analysis also supports the protective nature of blood group 'O' from severe falciparum infection.

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Genetic Analysis of ABO and Rh Blood Groups in Brahmin Population of Uttar Pradesh, India”

Cited by 4 publications

References 3 publications

The association of ABO blood group with the asymptomatic COVID-19 cases in India

The association of ABO blood group with the asymptomatic COVID-19 cases in India

The association of ABO blood group with the asymptomatic COVID-19 cases in India

Association of ABO blood group with severe falciparum malaria in adults: case control study and meta-analysis

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