Association of ABO blood group with severe falciparum malaria in adults: case control study and meta-analysis

Panda, Aditya K.; Panda, Santosh Kumar; Sahu, Aditya Narayan; Tripathy, Rina; Ravindran, Balachandran; Das, B. K.

doi:10.1186/1475-2875-10-309

Cited by 75 publications

(84 citation statements)

References 30 publications

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“…These authors also said that blood group A had a greater risk of developing severe Pf malaria. In our study, blood group B dominated the complicated Pf cases (63.6%), coinciding with studies by Panda AK et al (12) , followed by blood group O. But this was not statistically significant.…”

Section: Discussionsupporting

confidence: 79%

Relationship between Malaria and ABO Blood Group Types

2015

IJSR

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Abstract:Introduction: There is a paucity of studies on the relationship between ABO blood group and its influence on malarial infection. This study was undertaken to study the relationship of severity of malaria with blood groups and to evaluate if ABO blood groups show differential susceptibility to falciparummalaria. Methods: In 200 malaria positive patients, blood group analysis was done. Patients with at least one of the following complications was considered complicated malaria cases, ie: cerebral malaria, severe anemia, circulatory collapse, jaundice, hematuria, bleeding manifestations, acute respiratory distress syndrome, and death. Results: Vivax malaria (75.5%) and blood group O (43%) were the commonest amongst the cases. No significant relationship was present between blood groups and type of infection, parasite load vs blood groups, and complicated cases vs parasite load. Uncomplicated (62%) cases were more than complicated (31%) cases. Blood group O dominated among complicated (37.9%) and uncomplicated (45.65%) cases. No signifiant correlation was present between blood groups and distribution of complicated cases, and between complicated falciparum cases and blood groups. Seven cases of mixed malaria had blood group A and O. Among A blood group, 57.1% of the mixed malaria cases had complications, whereas in O blood group only 14.3% had complications. There was a statistically significant relation between complicated mixed malaria cases and blood groups, with blood group A being more prone to complications. (X 2 =15.131; P=0.019). Conclusions: Blood group O was the dominant blood type in both complicated and uncomplicated malaria cases. Blood group A cases were more prone to severe mixed malaria infections while, blood group O had a favorable clinical outcome.

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Section: Discussionsupporting

confidence: 79%

Relationship between Malaria and ABO Blood Group Types

2015

IJSR

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“…Questions still remain unanswered about the interactions between malaria parasites and other blood group antigens [45]. Panda et al, in India observed that the protective role of the blood group O and susceptibility of the blood group B to severe disease; and in a further meta-analysis of 19 relevant studies on falciparum malaria and the ABO blood group, the same findings of protection provided by the blood group O was noted but with susceptibility to the A and AB blood groups [43].…”

Section: Duffy Antigenmentioning

confidence: 62%

“…It has also been demonstrated that the blood group O provides some protection against severe falciparum malaria [41][42][43][44]. This protective effect of blood group O operates through the mechanism of reduced P. falciparum rosetting (binding of infected to uninfected erythrocytes) [41,44].…”

Section: Duffy Antigenmentioning

confidence: 99%

Protection Against Malaria in Man: a Probe into some of the Implicated Mechanisms in Sub-Saharan Africa

Chiabi¹,

Obadeyi²,

Mbassi³

et al. 2013

TOARSJ

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Abstract:Malaria is amongst the most common parasitic infections in the world. In Africa it causes one in every five childhood deaths, with one child dying of malaria every 30 seconds. People living in malaria endemic areas appear to have protective immune mechanisms, which may be naturally occurring or acquired from exposure to the malaria parasite. These protective factors play an important role in reducing morbidity and mortality from malaria. This review is aimed at exploring and explaining the mechanisms for a selection of the main protective factors to malaria in man. Using an extensive literature review of prominent articles, this paper identifies and summarizes these mechanisms which may be acquired or genetic. The challenge for the future will be to translate these notions into the development of interventions for the prevention and treatment of malaria.

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“…Importantly, there is still debate on this issue (6,18). In the study by Meyer (19), norovirus infection was the most common among individuals with blood group O.…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between blood groups and some infections such as norovirus, cholera, malaria, and Crimean-Congo fever has been reported (3,5). Some other studies have proposed that there is some relationship between blood type and severity of diseases (6). In addition, the relationship between blood groups and some diseases such as chronic urinary tract infections has been studied (7), but such a relationship has not been shown in other studies (8).…”

Section: Introductionmentioning

confidence: 99%