Genes do eixo somatotrófico e características de crescimento numa população F2 de bovinos

Silva, Marcos Vinícius Gualberto Barbosa da; Martinez, M. L.; Machado, M. A.; Nascimento, Carlos Souza do; Campos, Ana Lúcia; Guimarães, Marta; Azevedo, Ana Luisa Sousa; Moita, Antonia Kécya França; Lui, Jeffrey Frederico

doi:10.1590/s0100-204x2006000600013

Cited by 5 publications

(9 citation statements)

References 13 publications

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“…The HinfI (-) allele was the less frequent in the two genetic groups (Table 1). The predominance of the HinfI (+) allele was also detected in different European cattle breeds (Moody et al, 1995;Sabour et al, 1996;Klauzinska et al, 2000;Oprzadek et al, 2003), in Gir and crossbred dairy cattle (Mattos, 2000), and in Gir × Holstein crosses (Silva et al, 2006).…”

Section: Allele Frequenciesmentioning

confidence: 85%

“…PIT1 HinfI (-) allele was related to higher body weight at 7 months of age in double-muscled Belgian Blue bulls (Renaville et al, 1997) and higher weights at 60, 250, 365 days of age and on weight gain from born to 60 days of age in Gir × Holstein crosses (Silva et al, 2006). This polymorphism was associated with weaning weight in Nelore cattle (Conde et al, 2001).…”

Section: Allele Substitution Effectmentioning

confidence: 99%

“…A HinfI polymorphism is located within exon 6 and characterized by a silent mutation on HinfI (-) allele (Dierkes et al, 1998), and their effects were associated with growth traits in cattle (Conde et al, 2001;Silva et al, 2006). The objective of this study was to analyze the distribution of the Restriction Fragment Length Polymorphism (RFLP) PIT1-HinfI and to investigate the influence of allelic variants on traits related to growth in a herd of Canchim cattle.…”

Section: Introductionmentioning

confidence: 99%

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Association of PIT1 genotypes with growth traits in Canchim cattle

Carrijo

Alencar

Toral³

et al. 2008

Sci. agric. (Piracicaba, Braz.)

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Use of genetic markers can aid on the identification of animals with highest breeding values in beef cattle. The PIT1 gene codes for the Pit-1 transcription factor is essential for the activation of prolactin, growth hormone and PIT1 genes. This research is an investigation of the effect of PIT1-HinfI polymorphism on growth traits of 509 Canchim animals, from two lineages, GG1 and GG2. PIT1 genotypes were identified through PCR-RFLP. Genotype effect on phenotypic values for birth weight (BW), standardized weaning weight (W240), weight at 12 months of age (W365), and the average daily weight gain from birth to weaning (AGBW), and from weaning to 12 months of age (AGW12) were analyzed by the least squares method. Effects of the interaction between the animal's genetic group and PIT1 genotype for W240, AGBW and AGW12 were observed (P < 0.05). Differences between means of HinfI (-/-), HinfI (+/+) and HinfI (+/-) genotypes for W240 and AGBW were observed in GG2 (P < 0.05), revealing superiority of (-/-) genotype for those traits. Means for genotypes (+/+) and (+/-) for W240 and AGBW, did not differ from one another, suggesting a dominance effect of the HinfI (+) allele. The HinfI (-) allele had a favorable effect on W240 and AGBW in GG2, when present in homozygosis. The difference between PIT1 behavior observed in the two genetic groups may suggest the action of a quantitative trait locus linked to PIT1, segregating only in GG2 population. Key words: RFLP, bovine, pituitary factor 1, candidate gene ASSOCIAÇÃO DE GENÓTIPOS PIT1 COM CARACTERÍSTICAS DE CRESCIMENTO EM GADO CANCHIMRESUMO: O uso de marcadores genéticos pode favorecer a identificação de animais geneticamente superiores em bovino de corte. O gene PIT1 codifica para o fator de transcrição Pit-1, crítico para ativar a expressão dos genes da prolactina, hormônio de crescimento e PIT1. Esta pesquisa investiga o efeito do polimorfismo HinfI-PIT1 sobre características de crescimento em 509 animais da raça Canchim, pertencentes à duas linhagens, GG1 e GG2. Os genótipos do gene PIT1 foram identificados pela técnica PCR-RFLP. Os efeitos dos genótipos sobre valores fenotípicos para pesos ao nascimento (PN), pesos padronizados à desmama (P240) e ao ano (P365), ganhos médios diários de peso do nascimento à desmama (GMND), e da desmama aos 12 meses de idade (GMD12) foram analisados pelo método dos quadrados mínimos. Foram observados efeitos de interação entre grupo genético do animal e genótipo de PIT1 sobre P240, GMND e GMD12 (P < 0.05). Diferenças entre médias dos genótipos HinfI (-/-), HinfI (+/+) e HinfI (+/-) para P240 e GMND foram observadas em GG2 (P < 0,05), revelando superioridade do genótipo HinfI (-/-). As médias dos genótipos (+/+) e (+/-) para P240 e GMND, não diferiram, sugerindo efeito de dominância do alelo HinfI (+). O alelo HinfI (-) mostrou-se favorável sobre P240 e GMND em GG2, quando em homozigose. A diferença de comportamento de PIT1 observada nos dois grupos genéticos pode sugerir a ação de loco de característica quantitativa ligado ao ge...

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Section: Allele Frequenciesmentioning

confidence: 85%

Section: Allele Substitution Effectmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of PIT1 genotypes with growth traits in Canchim cattle

Carrijo

Alencar

Toral³

et al. 2008

Sci. agric. (Piracicaba, Braz.)

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“…However, association between GH and weight at other ages, such as at weaning [36] and at 12 months of age [37], were observed for Canchim cattle. In an F2 population (derived from Holstein x Gyr crosses), Silva et al [38] found significant association (p \ 0.001) of GH with body weight at 365 days of age. Our analyses did not confirm an association between GH and weight at different ages (WB, WW, W12, and W18) but there is evidence that GH is responsible for 26 % (p = 0.03) and 7 % (p = 0.08) of the phenotypic variation of WFC and BW, respectively.…”

Section: Association Analysesmentioning

confidence: 99%

“…Zhang et al [46] found no significant association (p [ 0.05) of the POU1F1 gene (formerly named PIT1) with body weight traits measured at four months of age in Qinchuan breed and its crossings with Angus, Limousin, and Germany Yellow breeds. Other studies showed association of PIT1 with body weight in one line of Canchim cattle [21], in double-muscled Belgian Blue cattle [47], and in an F2 Holstein x Gyr population [38].…”

Section: Association Analysesmentioning

confidence: 99%

Effect of IGF1, GH, and PIT1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle

et al. 2014

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The availability of dense genomic information has increased genome-wide association studies for the bovine species; however research to assess the effect of single genes on production traits is still important to elucidate the genes functions. On this study the association of IGF1, GH, and PIT1 markers with growth and reproductive traits (birth weight, weaning weight, weight at 12 and 18 months of age, preweaning average daily weight gain, age and weight at first calving, and scrotal circumference at 12 and 18 months of age) were assessed by means of the variance component approach. The phenotypes were adjusted and then analyzed under two animal models, one which considered the polygenic and genotype (IGF1, GH or PIT1 markers) effects (Model 1), and the other which considers only the polygenic effect (Model 2). When the likelihood ratio test and the Bonferroni correction was applied at 5 % significance level, the genetic markers for the IGF1, GH, and PIT1 genes did not influence significantly the traits (p > 0.002). However, evidence of association of IGF1 with birth weight (p = 0.06) and GH with weight at first calving (p = 0.03) and with weight at 12 months of age (p = 0.08) was observed. In conclusion we could not confirm the associations between IGF1, GH, and PIT1 and growth traits that were previously reported in Canchim cattle, and no association was observed between these genes and reproductive traits. Future studies involving functional markers of IGF1, GH and PIT1 genes may help to clarify the role of these genes in growth and reproductive processes.

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Associação de polimorfismo microssatélite no gene GH em Tambaqui (<i>Colossoma macropomum</i>) com características fenotípicas e expressão gênica

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Genes do eixo somatotrófico e características de crescimento numa população F2 de bovinos

Cited by 5 publications

References 13 publications

Association of PIT1 genotypes with growth traits in Canchim cattle

Association of PIT1 genotypes with growth traits in Canchim cattle

Effect of IGF1, GH, and PIT1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle

Associação de polimorfismo microssatélite no gene GH em Tambaqui (<i>Colossoma macropomum</i>) com características fenotípicas e expressão gênica

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