Effect of IGF1, GH, and PIT1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle

Abstract

The availability of dense genomic information has increased genome-wide association studies for the bovine species; however research to assess the effect of single genes on production traits is still important to elucidate the genes functions. On this study the association of IGF1, GH, and PIT1 markers with growth and reproductive traits (birth weight, weaning weight, weight at 12 and 18 months of age, preweaning average daily weight gain, age and weight at first calving, and scrotal circumference at 12 and 18 months of age) were assessed by means of the variance component approach. The phenotypes were adjusted and then analyzed under two animal models, one which considered the polygenic and genotype (IGF1, GH or PIT1 markers) effects (Model 1), and the other which considers only the polygenic effect (Model 2). When the likelihood ratio test and the Bonferroni correction was applied at 5 % significance level, the genetic markers for the IGF1, GH, and PIT1 genes did not influence significantly the traits (p > 0.002). However, evidence of association of IGF1 with birth weight (p = 0.06) and GH with weight at first calving (p = 0.03) and with weight at 12 months of age (p = 0.08) was observed. In conclusion we could not confirm the associations between IGF1, GH, and PIT1 and growth traits that were previously reported in Canchim cattle, and no association was observed between these genes and reproductive traits. Future studies involving functional markers of IGF1, GH and PIT1 genes may help to clarify the role of these genes in growth and reproductive processes.

Assessment of growth hormone gene polymorphism effects on reproductive traits in Holstein dairy cattle in Tunisia

“…Therefore the frequency of the V allele was lower than the L allele (87.045 vs. 12.955). Allele and genotype frequencies for the GH-AluI polymorphisms given in this work were in agreement with those reported in previous studies, which have been discussed extensively in Holstein dairy cows (Balogh et al, 2009b;Ruprechte et al, 2011;Grossi et al, 2015). However, other findings have shown the dominance of the heterozygous genotype LV and the absence of the homozygous genotype VV (Aruna et al, 2004;Hadi et al, 2015).…”

“…Similarly, no obvious association of GH with AGE_1CALV and CI was observed in Canchim and Hungarian Holstein-Friesian cattle (Kovacs et al, 2006;Grossi et al, 2015) and with AGE_1CALV in a Hungarian Holstein-Friesian bull dam population (Katalin et al, 2006). Moreover, Kovacs et al (2006) reported no noteworthy effect of GH-AluI on the CI, the number of calves or the dry period in a Hungarian Holstein-Friesian bull dam.…”

“…No significant association has been reported between AluI polymorphism and the following traits: age at the first calving (Kovács et al, 2006;Grossi et al, 2015), the number of oocytes suitable for in vitro maturation, the number of matured oocytes, the mean oocyte diameter, and the number of embryos produced (Lechniak et al, 2002). However, a significant association was observed for milk yield, milk fat and protein (Dybus, 2002;Kovács et al, 2006), in addition to beef bulls non-return rates (Lechniak et al, 2002).…”

Combining multi-OMICs information to identify key-regulator genes for pleiotropic effect on fertility and production traits in beef cattle

“…The IGF1 pathway influence gonadotrophin‐releasing hormone (GnRH) neurons during the puberty and it is directly associated with the puberty progression and the development of reproductive traits [ 52 , 63 , 64 ]. Additionally, IGF1 was associated with the regulation of several production traits, for example, feed intake, feed conversion, body weight, milk protein yield, milk fat yield, milk fat concentration and somatic cell score [ 65 – 67 ]. Variants mapped on IGF1R may result in a change of affinity between IGF1 and its receptor, resulting in a different response to the circulating levels of this hormone.…”

Rapid morphological divergence following a human-mediated introduction: the role of drift and directional selection

“…This included: OBSL1-a cytoskeletal adaptor protein previously associated with body size in humans (Hanson et al 2009) and cetaceans (Sun et al 2019); and IGF1R-a transmembrane receptor of insulin-like growth factor 1 (IGF1). The IGF1 pathway has a well-known role in body size scaling in a range of taxa, including chickens (Beccavin et al 2001;Beckman et al 2003), cattle (Grossi et al 2015), brown house snakes (Sparkman et al 2010) and dogs (Sutter et al 2007); and has been previously associated with bill size in the black-bellied seedcracker (onHoldt et al 2018). RUNX3-which, in the zebrafish, modulates bone morphogenetic protein (BMP) signalling during craniofacial development (Dalcq et al 2012).…”