Generation of water-in-oil and oil-in-water microdroplets in polyester-toner microfluidic devices

Piccin, Evandro; Ferraro, Davide; Sartori, P.; Chiarello, Enrico; Mistura, Giampaolo

doi:10.1016/j.snb.2014.02.042

Cited by 41 publications

(24 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Imaging and Analysissupporting

confidence: 91%

“…Overall, the droplet length is found to decrease as the capillary number increases and to increase as the flow rate ratio increases. This trend is consistent with other studies where droplet production is controlled by two immiscible streams in a variety of different geometries [7,25,35]. In the squeezing regime, i.e., for Ca ≲ 0.01, the length of the drops can be conveniently expressed with the following scaling equation = α + α , where α1 and α2 are two constants of order one that depend on the junction geometry [10,36,37].…”

Section: Imaging and Analysissupporting

confidence: 89%

“…As in Figure 4, the droplet length increases almost linearly with the dispersed flow rate = φ. Furthermore, decreases with increasing the continuous flow rate, again in agreement with the general trend found in Newtonian fluids [10,25,35,36]. The data corresponding to Qc = 0.2 μL/min practically coincide with those obtained with the 60% (w/w) glycerol/water solution, confirming that also at this continuous flow rate the dynamic behavior of the 800 ppm xanthan solution in the T-junction is very similar to that of the 60% glycerol solution.…”

Section: Newtonian Droplets In a Non-newtonian Continuous Phasesupporting

confidence: 86%

“…θ " 1 s´1), and with a 60% (w/w) glycerol/water solution whose viscosity is nine times smaller than the denser (85% (w/w) glycerol/water) one. The droplet length in glycerol solutions increases linearly with the flow rate of the dispersed phase Q d " Q c ϕ as expected [10,25,35,36]. Instead, increasing the viscosity of the continuous phase produces shorter plugs [35,36,39], see also Figure 1.…”

Section: Newtonian Droplets In a Non-newtonian Continuous Phasesupporting

confidence: 60%

“…Thus, the width of the main channel had to be greater than its height and the width of the inlet channel had be at least equal to half the width of the main channel [10], see Figure 1. We started the fabrication using polyester-toner (PeT) devices made by direct-printing combined with xurography because they were shown to be suitable to produce oil-in-water (O/W) droplets without using any surface treatment of the microchannels' walls [25].…”

Section: Fabricationmentioning

confidence: 99%

See 4 more Smart Citations

Generation of Oil Droplets in a Non-Newtonian Liquid Using a Microfluidic T-Junction

et al. 2015

Self Cite

View full text Add to dashboard Cite

Abstract:We have compared the formation of oil drops in Newtonian and non-Newtonian fluids in a T-junction microfluidic device. As Newtonian fluids, we used aqueous solutions of glycerol, while as non-Newtonian fluids we prepared aqueous solutions of xanthan, a stiff rod-like polysaccharide, which exhibit strong shear-thinning effects. In the squeezing regime, the formation of oil droplets in glycerol solutions is found to scale with the ratio of the dispersed flow rate to the continuous one and with the capillary number associated to the continuous phase. Switching to xanthan solutions does not seem to significantly alter the droplet formation process. Any quantitative difference with respect to the Newtonian liquid can be accounted for by a suitable choice of the capillary number, corresponding to an effective xanthan viscosity that depends on the flow rates. We have deduced ample variations in the viscosity, on the order of 10 and more, during normal operation conditions of the T-junction. This allowed estimating the actual shear rates experienced by the xanthan solutions, which go from tens to hundreds of s´1.

show abstract

Section: Imaging and Analysissupporting

confidence: 91%

Section: Imaging and Analysissupporting

confidence: 89%

Section: Newtonian Droplets In a Non-newtonian Continuous Phasesupporting

confidence: 86%

Section: Newtonian Droplets In a Non-newtonian Continuous Phasesupporting

confidence: 60%

Section: Fabricationmentioning

confidence: 99%

See 3 more Smart Citations

Generation of Oil Droplets in a Non-Newtonian Liquid Using a Microfluidic T-Junction

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

Inexpensive and nonconventional fabrication of microfluidic devices in PMMA based on a soft‐embossing protocol

et al. 2020

View full text Add to dashboard Cite

This study describes an inexpensive and nonconventional soft-embossing protocol to produce microfluidic devices in poly(methyl methacrylate) (PMMA). The desirable microfluidic structure was photo-patterned in a poly(vinyl acetate) (PVAc) film deposited on glass substrate to produce a low-relief master. Then, this template was used to generate a highrelief pattern in stiffened PDMS by increasing of curing agent /monomer ratio (1:5) followed by thermal aging in a laboratory oven (200°C for 24 h). The stiffened PDMS masters were used to replicate microfluidic devices in PMMA based on soft embossing at 220-230°C and thermal sealing at 140°C. Both embossing and sealing stages were performed by using binder clips. The proposed protocol has ensured the replication of microfluidic devices in PMMA with great fidelity (>94%). Examples of MCE devices, droplet generator devices and spot test array were successfully demonstrated. For testing MCE devices, a mixture containing inorganic cations was selected as model and the achieved analytical performance did not reveal significant difference from commercial PMMA devices. Water droplets were successfully generated in an oil phase at rate of ca. 60 droplets/min (fixing the continuous phase flow rate at 100 μL/h) with size of ca. 322 ± 6 μm. Glucose colorimetric assay was performed on spot test devices and good detectability level (5 μmol/L) was achieved. The obtained results for two artificial serum samples revealed good agreement with the certified concentrations. Based on the fabrication simplicity and great analytical performance, the proposed soft-embossing protocol may emerge as promising approach for manufacturing PMMA devices.

show abstract

Development of a rapid manufacturable microdroplet generator with pneumatic control

et al. 2020

View full text Add to dashboard Cite

Generation of water-in-oil and oil-in-water microdroplets in polyester-toner microfluidic devices

Cited by 41 publications

References 32 publications

Generation of Oil Droplets in a Non-Newtonian Liquid Using a Microfluidic T-Junction

Generation of Oil Droplets in a Non-Newtonian Liquid Using a Microfluidic T-Junction

Inexpensive and nonconventional fabrication of microfluidic devices in PMMA based on a soft‐embossing protocol

Development of a rapid manufacturable microdroplet generator with pneumatic control

Contact Info

Product

Resources

About