Development of a rapid manufacturable microdroplet generator with pneumatic control

Nagesh, G.; Hualong, Wang; Ting, David S.‐K.; Ahamed, Mohammed Jalal

doi:10.1007/s00542-020-05052-9

Cited by 9 publications

(5 citation statements)

References 42 publications

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“…Moreover, this platform can be used immediately to maximize the information content associated with single-cell microfluidic experiments, thus representing a flexible and cost-effective tool for high-precision screening applications. Nagesh et al also used a T-junction microdroplet generator combined with pneumatic actuation to control the droplet size [ 87 ]. Table 1 presents a comparison of different droplet generation techniques using the microfluidic approach.…”

Section: Droplet-based Microfluidicsmentioning

confidence: 99%

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Trinh,

Do,

Nam

et al. 2023

Pharmaceuticals

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Droplet-based microfluidics offer great opportunities for applications in various fields, such as diagnostics, food sciences, and drug discovery. A droplet provides an isolated environment for performing a single reaction within a microscale-volume sample, allowing for a fast reaction with a high sensitivity, high throughput, and low risk of cross-contamination. Owing to several remarkable features, droplet-based microfluidic techniques have been intensively studied. In this review, we discuss the impact of droplet microfluidics, particularly focusing on drug screening and development. In addition, we surveyed various methods of device fabrication and droplet generation/manipulation. We further highlight some promising studies covering drug synthesis and delivery that were updated within the last 5 years. This review provides researchers with a quick guide that includes the most up-to-date and relevant information on the latest scientific findings on the development of droplet-based microfluidics in the pharmaceutical field.

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Section: Droplet-based Microfluidicsmentioning

confidence: 99%

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Trinh,

Do,

Nam

et al. 2023

Pharmaceuticals

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“…Electrospray droplet generators rely on the application of an electric field to generate droplets from a liquid in a continuous stream; however, their sensitivity to the properties of the liquid being processed and the need for specialized equipment limits their practicality and versatility in some biomedical applications [24]. Pneumatic generators use compressed air to atomize a liquid stream into droplets while sonication droplet generators use ultrasound to break a liquid into droplets [25,26]. They share the major drawbacks of pressure droplet generators in controlling droplet size and handling viscous liquids [23,25,26].…”

Section: Employing Hydrogel Droplets In Tissue Engineeringmentioning

confidence: 99%

“…Pneumatic generators use compressed air to atomize a liquid stream into droplets while sonication droplet generators use ultrasound to break a liquid into droplets [25,26]. They share the major drawbacks of pressure droplet generators in controlling droplet size and handling viscous liquids [23,25,26].…”

Section: Employing Hydrogel Droplets In Tissue Engineeringmentioning

confidence: 99%

Emerging Advances in Microfluidic Hydrogel Droplets for Tissue Engineering and STEM Cell Mechanobiology

Orabi,

2023

Gels

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Hydrogel droplets are biodegradable and biocompatible materials with promising applications in tissue engineering, cell encapsulation, and clinical treatments. They represent a well-controlled microstructure to bridge the spatial divide between two-dimensional cell cultures and three-dimensional tissues, toward the recreation of entire organs. The applications of hydrogel droplets in regenerative medicine require a thorough understanding of microfluidic techniques, the biocompatibility of hydrogel materials, and droplet production and manipulation mechanisms. Although hydrogel droplets were well studied, several emerging advances promise to extend current applications to tissue engineering and beyond. Hydrogel droplets can be designed with high surface-to-volume ratios and a variety of matrix microstructures. Microfluidics provides precise control of the flow patterns required for droplet generation, leading to tight distributions of particle size, shape, matrix, and mechanical properties in the resultant microparticles. This review focuses on recent advances in microfluidic hydrogel droplet generation. First, the theoretical principles of microfluidics, materials used in fabrication, and new 3D fabrication techniques were discussed. Then, the hydrogels used in droplet generation and their cell and tissue engineering applications were reviewed. Finally, droplet generation mechanisms were addressed, such as droplet production, droplet manipulation, and surfactants used to prevent coalescence. Lastly, we propose that microfluidic hydrogel droplets can enable novel shear-related tissue engineering and regeneration studies.

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“…The passive method does not involve any external devices, and the droplets are generated through the squeezing, dripping, or jetting mechanisms 9–11 . However, the droplet formation is influenced by various parameters including the channel geometry, flow rate, fluid viscosity, interfacial tension, etc 8,12–17 . The droplet size and generation frequency also correlate to each other and cannot be controlled independently.…”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11] However, the droplet formation is influenced by various parameters including the channel geometry, flow rate, fluid viscosity, interfacial tension, etc. 8,[12][13][14][15][16][17] The droplet size and generation frequency also correlate to each other and cannot be controlled independently. This limits the application of droplet microfluidics, especially in the cases where multiple droplets of different sizes and properties need to be simultaneously handled.…”

Section: Introductionmentioning

confidence: 99%

Numerical study on active droplet generation governed by pulsatile continuous‐phase flow

Zhang,

Wang,

et al. 2023

Asia-Pacific J Chem Eng

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Precise control on the droplet generation is an important issue for the application of droplet microfluidics. Passive formation of droplets depends on multiparameters. The droplet size and generation frequency highly correlate to each other, raising the control difficulty. In comparison, the active method through external perturbations is more flexible. In this work, the droplet generation governed by pulsatile continuous‐phase flow is numerically studied. The effects of the pulsation amplitude and frequency, as well as the velocity and viscosity of the discrete fluid are investigated. Different modes of droplet generation (viz., sub‐periodic, period‐1, and period‐n modes) are identified, the underlying mechanisms are interpreted. This method may be applied in various droplet microfluidic/microreactor systems to improve the droplets control and manipulations.

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Development of a rapid manufacturable microdroplet generator with pneumatic control

Cited by 9 publications

References 42 publications

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Emerging Advances in Microfluidic Hydrogel Droplets for Tissue Engineering and STEM Cell Mechanobiology

Numerical study on active droplet generation governed by pulsatile continuous‐phase flow

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