Generalized Keratosis Lichenoides Chronica Induced By Antituberculosis Therapy: A Case Report

Zindancı, İlkin; Okur, Hacer Kuzu; Zemheri, Ebru; Can, Burçe; Türkoğlu, Zafer; Kavala, Mukaddes; Akbulak, Özge; Topaloglu, Filiz

doi:10.5505/respircase.2014.58569

Cited by 2 publications

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References 4 publications

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“…Mode of inheritance, infl uence of any other genetic alteration, relationship with any drugs or infection, has not been defi ned (1). Th e most common factors causing KLC as a variant of lichenoid drug eruption are antimalarials, antituberculosis agents (11,20,123), and tetanus antiserum (18); KLC may also be induced by mechanical skin damage, for example after trauma or skin transplantation (50,84), or it is a cutaneous manifestation of toxoplasmosis (27).…”

Section: Literature Reviewmentioning

confidence: 99%

Keratosis Lichenoides Chronica – a Case Report and Literature Review

Paravina

Cvetanović²,

Kostov³

et al. 2014

Serbian Journal of Dermatology and Venereology

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linear and reticular red to purple papules with white scaly surface. Before the appearance of skin lesions, the patient's history was unremarkable and he denied taking any medications. He was treated under the diagnosis of psoriasis vulgaris, and lichen verrucosus. In 2014, he underwent phimosis surgery. Th ere was no family history of skin conditions. ExaminationOn admission, the patient presented with symmetrical generalized eruptions of erythemolivid to dark livid papules and nodules with a keratotic surface, in a solitary, linear or reticular pattern on the lower lateral parts of the trunk and along the extremities ( Figures 1-3); the infi ltrated lesions were prominent, verrucous and hyperkeratotic. Mild erythematosquamous lesions were present on the face. Solitary erythematous papules on erythematous base T he idea for this paper on keratosis lichenoides chronica (KLC) was born after the fi rst visit of a patient with an unusual clinical picture resembling both psoriasis and lichen planus, but also distinct from them, posing a diagnostic and therapeutic dilemma. After a consultation with Prof. Danilo Stevanović, whom we hereby wish to thank, and repeated histopathological examinations, the diagnosis of keratosis lichenoides chronica was confi rmed. Papers of Böer (1) Case report Case historyWe report a 40-year old man who developed skin lesions on the trunk and extremities more than 10 years earlier: asymptomatic, symmetrically distributed AbstractKeratosis lichenoides chronica represents a distinct entity, a rare disease of unknown etiology and pathogenesis, with clinical manifestations which, although typical, require extensive differential diagnosis. The course of the disease is chronic, progressive, and it is resistant to various treatment options, so despite variations in the clinical picture it is really easier to diagnose than to treat. This is a case report of a male patient in whom the diagnosis of keratosis lichenoides chronica was based on typical clinical picture, repeated biopsies and histopathological findings, course of the disease and poor response to any therapy.

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Section: Literature Reviewmentioning

confidence: 99%

Keratosis Lichenoides Chronica – a Case Report and Literature Review

Paravina

Cvetanović²,

Kostov³

et al. 2014

Serbian Journal of Dermatology and Venereology

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Pyrazinamide

2014

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Pyrazinamide First report of keratosis lichenoides chronica: case reportA 58-year-old man developed keratosis lichenoides chronica (KLC) while receiving treatment with antituberculosis drugs including pyrazinamide [dosage and route not stated].The man, with a history of pulmonary tuberculosis, initiated treatment with pyrazinamide, isoniazid, rifampicin and ethambutol. On day 10, he developed a rash starting from the torso disseminating throughout the body. He was admitted with the complaint of a generalized rash with erythema-tous, scaly plaques. Violaceous erythematous, scaly and infiltrated plaques were found all over his body on dermatological examination. Lesions were predominantly located on the torso, and upper and lower extremities, which had a tendency for coalescence. A biopsy of lesions showed focal parakeratosis, focal exocytosis, irregular acanthosis, basal vacuolar degeneration, colloid bodies, necrotic cells, and lichenoid infiltration. He was subsequently diagnosed with KLC.

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Generalized Keratosis Lichenoides Chronica Induced By Antituberculosis Therapy: A Case Report

Cited by 2 publications

References 4 publications

Keratosis Lichenoides Chronica – a Case Report and Literature Review

Keratosis Lichenoides Chronica – a Case Report and Literature Review

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