General and Domain-Specific Effectiveness of Cognitive Remediation after Stroke: Systematic Literature Review and Meta-Analysis

Rogers, Jeffrey M.; Foord, Rachael; Stolwyk, Renerus J.; Wong, Dana; Wilson, Peter H.

doi:10.1007/s11065-018-9378-4

Cited by 52 publications

(52 citation statements)

References 115 publications

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“…For stroke, we found that meta-analyses of CT interventions targeting a specific cognitive domain, such as memory (das Nair et al, 2016) and attention (Loetscher & Lincoln, 2013;Virk et al, 2015) showed no significant effect, however, results were imprecise and based on a small number of primary trials. In contrast, there was evidence from a moderate-quality review including 22 primary trials covering a variety of cognitive remediation techniques (Rogers et al, 2018), to support the use of COTs to improve cognitive performance following stroke.…”

Section: Summary Of Main Resultsmentioning

confidence: 98%

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Cognition-oriented treatments for older adults: A systematic overview of systematic reviews

Gavelin¹,

Lampit²,

Hallock³

et al. 2019

Preprint

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Cognition-oriented treatments (COTs) -commonly categorized as cognitive training, cognitive rehabilitation and cognitive stimulation -are promising approaches for the prevention of cognitive and functional decline in older adults. We conducted a systematic overview of meta-analyses investigating the efficacy of COTs on cognitive and non-cognitive outcomes in older adults with or without cognitive impairment. Review quality was assessed by AMSTAR 2. We identified 51 eligible reviews, 46 of which were included in the quantitative synthesis. The confidence ratings were "moderate" for 9 (20%), "low" for 13 (28%) and "critically low" for 24 (52%) of the 46 reviews. While most reviews provided pooled effect estimates for objective cognition, non-cognitive outcomes of potential relevance were more sparsely reported. The mean effect estimate on cognition was small for cognitive training in healthy older adults (Hedge's g 0.32, range 0.13-0.64, 19 reviews), mild cognitive impairment (Hedge's g 0.40, range 0.32-0.60, five reviews), and dementia (Hedge's g 0.38, range 0.09-1.16, seven reviews), and small for cognitive stimulation in dementia (Hedge's g 0.36, range 0.26-0.44, five reviews). Meta-regression revealed that higher AMSTAR score was associated with larger effect estimates for cognitive outcomes. The available evidence supports the efficacy of COTs improving cognitive performance in older adults. The extent to which such effects are of clinical value remains unclear, due to the scarcity of high-quality evidence and heterogeneity in reported findings. An important avenue for future trials is to include relevant non-cognitive outcomes in a more consistent way and, for meta-analyses in the field, there is a need for better adherence to methodological standards. PROSPERO registration number: CRD42018084490.

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Section: Summary Of Main Resultsmentioning

confidence: 98%

“…Six were classified as mixed COTs (Chandler et al, 2016;Lee et al, 2019;P. Leung et al, 2017;Rogers et al, 2018;Sherman et al, 2017;Yang et al, 2018), one of which focused specifically on COTs with caregiver involvement (P. Leung et al, 2017).…”

Section: Interventionsmentioning

confidence: 99%

Cognition-oriented treatments for older adults: A systematic overview of systematic reviews

Gavelin¹,

Lampit²,

Hallock³

et al. 2019

Preprint

View full text Add to dashboard Cite

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“…One of these reviews included people with dementia living in long-term care facilities (Folkerts et al, 2017). Two reviews focused on PD (Lawrence, Gasson, Bucks, Troeung, & Loftus, 2017;Leung et al, 2015) and four on individuals with stroke (das Nair, Cogger, Worthington, & Lincoln, 2016;Loetscher & Lincoln, 2013;Rogers, Foord, Stolwyk, Wong, & Wilson, 2018;Virk, Williams, Brunsdon, Suh, & Morrow, 2015). Five reviews were classified as a mixed population, three included individuals with MCI and dementia (Hoefler, 2016;Kurz, Leucht, & Lautenschlager, 2011;Yang et al, 2018), one stated that they looked at participants without dementia (Floyd & Scogin, 1997) and one did not specify cognitive status (Pinquart & Sörensen, 2001).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Six were classified as mixed cognitionoriented treatments (Chandler et al, 2016;Lee et al, 2019;P. Leung et al, 2017;Rogers et al, 2018;Sherman et al, 2017;Yang et al, 2018), one of which focused specifically on cognition-oriented treatments with caregiver involvement (P. Leung et al, 2017).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Cognition-Oriented Treatments for Older Adults: a Systematic Overview of Systematic Reviews

et al. 2020

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Cognition-oriented treatmentscommonly categorized as cognitive training, cognitive rehabilitation and cognitive stimulationare promising approaches for the prevention of cognitive and functional decline in older adults. We conducted a systematic overview of meta-analyses investigating the efficacy of cognition-oriented treatments on cognitive and non-cognitive outcomes in older adults with or without cognitive impairment. Review quality was assessed by A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR). We identified 51 eligible reviews, 46 of which were included in the quantitative synthesis. The confidence ratings were "moderate" for 9 (20%), "low" for 13 (28%) and "critically low" for 24 (52%) of the 46 reviews. While most reviews provided pooled effect estimates for objective cognition, non-cognitive outcomes of potential relevance were more sparsely reported. The mean effect estimate on cognition was small for cognitive training in healthy older adults (mean Hedges' g = 0.32, range 0.13-0.64, 19 reviews), mild cognitive impairment (mean Hedges' g = 0.40, range 0.32-0.60, five reviews), and dementia (mean Hedges' g = 0.38, range 0.09-1.16, seven reviews), and small for cognitive stimulation in dementia (mean Hedges' g = 0.36, range 0.26-0.44, five reviews). Meta-regression revealed that higher AMSTAR score was associated with larger effect estimates for cognitive outcomes. The available evidence supports the efficacy of cognition-oriented treatments improving cognitive performance in older adults. The extent to which such effects are of clinical value remains unclear, due to the scarcity of high-quality evidence and heterogeneity in reported findings. An important avenue for future trials is to include relevant non-cognitive outcomes in a more consistent way and, for meta-analyses in the field, there is a need for better adherence to methodological standards. PROSPERO registration number: CRD42018084490.

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“…Stroke is a leading cause of death and long-term disability worldwide (1,2). Despite the decrease in the incidence and mortality rates associated with stroke in high-income countries, the condition in low-and middleincome countries has worsened noticeably over the last four decades (3).…”

Section: Introductionmentioning

confidence: 99%

Positive Effects of Post-ischemic Forced Treadmill Training on Sensorimotor and Learning Outcomes Following Transient Global Cerebral Ischemia

et al. 2019

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Background and objectives: Stroke is one of the leading causes of death and long-term acquired disability. It is of great importance to seek ways for improving motor, sensory, and cognitive function after stroke and brain injury. In this regard, therapeutic exercise is the most commonly used method of rehabilitation that can significantly reduce the severity of functional damage. The aim of the present study was to investigate effects of eight weeks of forced treadmill training on cognitive and motor functions in ischemic rats.Methods: Fourteen adult male Wistar rats were divided into an exercise group and a control group (no exercise). Occlusion of both common carotid arteries was made to induce cerebral ischemia. Twenty-four hours after the induction of ischemia, the subjects in the exercise group were subjected to treadmill running, five days a week for eight weeks. The skilled ladder rung walking task was used to evaluate motor function before and after the stroke.Results: The number of errors was decreasing in both groups, but significant differences were observed in the motor function between the two groups in the third, fifth, and eighth week.Conclusion: Our results suggest that post-ischemic exercise might modulate ischemia-induced hippocampal injury and ameliorate the subsequent memory and motor impairment.

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General and Domain-Specific Effectiveness of Cognitive Remediation after Stroke: Systematic Literature Review and Meta-Analysis

Cited by 52 publications

References 115 publications

Cognition-oriented treatments for older adults: A systematic overview of systematic reviews

Cognition-oriented treatments for older adults: A systematic overview of systematic reviews

Cognition-Oriented Treatments for Older Adults: a Systematic Overview of Systematic Reviews

Positive Effects of Post-ischemic Forced Treadmill Training on Sensorimotor and Learning Outcomes Following Transient Global Cerebral Ischemia

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