Gender-Specific Associations of Serum Insulin-Like Growth Factor-1 With Bone Health and Fractures in Older Persons

Abstract

Associations of lower IGF-1 with lower BUA, greater 3-year decrease in BMD, and increased 10-year fracture risk were only observed in women, not in men. These results support previous findings of gender differences in the relationship between IGF-1 and bone in older individuals.

The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research

“…Several cross-sectional studies conducted in older populations have found a positive correlation between IGF-1 levels and BMD specific to women or men only (Janssen et al, 1998; Langlois et al, 1998). Prospective analysis confirmed a similar association in women (van Varsseveld et al, 2015). Low IGF-1 level has been linked to increased risk of future fracture in men and women, although not all studies have shown consistent sex-specific effects (Ohlsson et al, 2011; van Varsseveld et al, 2015; Yamaguchi et al, 2006).…”

“…Prospective analysis confirmed a similar association in women (van Varsseveld et al, 2015). Low IGF-1 level has been linked to increased risk of future fracture in men and women, although not all studies have shown consistent sex-specific effects (Ohlsson et al, 2011; van Varsseveld et al, 2015; Yamaguchi et al, 2006). …”

High-intensity interval training (HIIT) increases insulin-like growth factor-I (IGF-I) in sedentary aging men but not masters’ athletes: an observational study

“…The reduction in circulating anabolic hormones, namely growth hormone (GH) and IGF-I, has been termed 'somatopause', and suggested as a potential mechanism for the atrophic sequelae of aging [1]. IGF-I is considered to play a central role in the age-associated compromise of both skeletal [2], and muscle [3] integrity.…”

Associations of insulin‐like growth factor‐I and insulin‐like growth factor binding protein‐3 with bone quality in the general adult population

“…Interestingly, in both, children and adults, GH replacement therapy leads to an improvement in BMD . Apart from GHD and patients with acromegaly, positive associations of IGF‐I with BMD or osteoporosis have been demonstrated in various studies . IGF‐I was even proposed as the earliest among five important markers, including osteoprotegerin, leptin, osteocalcin and urinary N‐terminal telopeptide of type I collagen, for the detection of osteoporosis .…”

“…Taken together, the associations between IGF‐I or IGFBP‐3 and BMD as well as osteoporosis have been assessed in several, even large studies including up to 627 men and 656 women, but sex‐specific associations remain uncertain. Moreover, only a few studies examined the association of IGF‐I or IGFBP‐3 on bone quality assessed by quantitative ultrasound (QUS).…”