High-intensity interval training (HIIT) increases insulin-like growth factor-I (IGF-I) in sedentary aging men but not masters’ athletes: an observational study

Herbert, Peter N.; Hayes, Lawrence D.; Sculthorpe, Nicholas; Grace, Fergal

doi:10.1080/13685538.2016.1260108

Cited by 24 publications

(28 citation statements)

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“…[ 30 ] However, the tenet for this phenomenon is not well described in the ageing male literature, [ 31 , 32 ] and the latest evidence introduces the potential for a significant role of insulin-like growth factor in the exercise response in ageing men. [ 33 ] Nonetheless, increases in muscle mass in this study would have the additional benefit of increasing resting metabolic rate, which may also explain the accelerated reduction in TBF after L f HIIT. Nevertheless, whatever the basis for increased LBM, the present study builds on previous work by demonstrating that in older cohorts, increases in LBM are possible, and can occur despite low exercise frequency and volumes.…”

Section: Discussionmentioning

confidence: 93%

One session of high-intensity interval training (HIIT) every 5 days, improves muscle power but not static balance in lifelong sedentary ageing men

2017

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Background:Declining muscle power during advancing age predicts falls and loss of independence. High-intensity interval training (HIIT) may improve muscle power, but remains largely unstudied in ageing participants.Methods:This randomized controlled trial (RCT) investigated the efficacy of a low-frequency HIIT (LfHIIT) intervention on peak muscle power (peak power output [PPO]), body composition, and balance in lifelong sedentary but otherwise healthy males.Methods:Thirty-three lifelong sedentary ageing men were randomly assigned to either intervention (INT; n = 22, age 62.3 ± 4.1 years) or control (n = 11, age 61.6 ± 5.0 years) who were both assessed at 3 distinct measurement points (phase A), after 6 weeks of conditioning exercise (phase B), and after 6 weeks of HIIT once every 5 days in INT (phase C), where control remained inactive throughout the study.Results:Static balance remained unaffected, and both absolute and relative PPO were not different between groups at phases A or B, but increased significantly in INT after LfHIIT (P < 0.01). Lean body mass displayed a significant interaction (P < 0.01) due to an increase in INT between phases B and C (P < 0.05).Conclusions:6 weeks of LfHIIT exercise feasible and effective method to induce clinically relevant improvements in absolute and relative PPO, but does not improve static balance in sedentary ageing men.

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Section: Discussionmentioning

confidence: 93%

One session of high-intensity interval training (HIIT) every 5 days, improves muscle power but not static balance in lifelong sedentary ageing men

2017

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“…2015; Herbert et al. 2017), and therefore only a subset of participants were analyzed. As such, our results remain preliminary until the influence of exercise habits on serum GDF11 is investigated with either a large‐scale randomized control trial (RCT) or prospective observational trial.…”

Section: Discussionmentioning

confidence: 99%

“…2017; Herbert et al. 2017), which was approved by the University of the West of Scotland Ethics Committee (Reference: UEC16_042012/Herbert). Participants were familiarized with experimental procedures and approval to exercise was given by their general practitioner.…”

Section: Methodsmentioning

confidence: 99%

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Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation

et al. 2017

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Lifelong exercise is associated with regulation of skeletal mass and function, reductions in frailty, and successful aging. Yet, the influence of exercise on myostatin and myostatin‐interacting factors is relatively under examined in older males. Therefore, we investigated whether serum total myostatin, free myostatin, follistatin, and growth and differentiation factor 11 (GDF11) were altered following high‐intensity interval training (HIIT) in a group of 13 lifelong sedentary (SED; 64 [6] years) and 11 lifelong exercising (LEX; 62 [6] years) older males. SED follistatin was moderately greater than LEX pre‐HIIT (Cohen's d = 0.66), and was largely greater post‐HIIT (Cohen's d = 1.22). The HIIT‐induced increase in follistatin was large in SED (Cohen's d = 0.82) and absent in LEX (Cohen's d = 0.03). GDF11 was higher in LEX pre‐HIIT (Cohen's d = 0.49) and post‐HIIT (Cohen's d = 0.63) compared to SED. HIIT resulted in no change to GDF11 in LEX or SED (Cohen's d = 0.00–0.03). Peak power output and GDF11 were correlated (r = 0.603), independent of grouping. Differences in GDF11 with lifelong exercise training, paired with the correlation between GDF11 and peak power output, suggested that GDF11 may be a relevant myostatin‐interacting peptide to successful aging in humans, and strategies to maintain this need to be further explored.

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“…Blood samples from each participant were collected at phase A, B and C, at 07:00–09:00 h, 48–72 h following the last exercise session as previously described ( 23 , 24 , 25 , 26 ). Serum concentrations of TT, sex hormone-binding globulin (SHBG) and cortisol were determined by electrochemiluminescent immunoassay on the E601 module of the Roche Cobas 6000.…”

Section: Methodsmentioning

confidence: 99%

HIIT produces increases in muscle power and free testosterone in male masters athletes

Herbert

Hayes

Sculthorpe

et al. 2017

Endocrine Connections

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High-intensity interval training (HIIT) improves peak power output (PPO) in sedentary aging men but has not been examined in masters endurance athletes. Therefore, we investigated whether a six-week program of low-volume HIIT would (i) improve PPO in masters athletes and (ii) whether any change in PPO would be associated with steroid hormone perturbations. Seventeen male masters athletes (60 ± 5 years) completed the intervention, which comprised nine HIIT sessions over six weeks. HIIT sessions involved six 30-s sprints at 40% PPO, interspersed with 3 min active recovery. Absolute PPO (799 ± 205 W and 865 ± 211 W) and relative PPO (10.2 ± 2.0 W/kg and 11.0 ± 2.2 W/kg) increased from pre- to post-HIIT respectively (P < 0.001, Cohen’s d = 0.32−0.38). No significant change was observed for total testosterone (15.2 ± 4.2 nmol/L to 16.4 ± 3.3 nmol/L (P = 0.061, Cohen’s d = 0.32)), while a small increase in free testosterone occurred following HIIT (7.0 ± 1.2 ng/dL to 7.5 ± 1.1 ng/dL pre- to post-HIIT (P = 0.050, Cohen’s d = 0.40)). Six weeks’ HIIT improves PPO in masters athletes and increases free testosterone. Taken together, these data indicate there is a place for carefully timed HIIT epochs in regimes of masters athletes.

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High-intensity interval training (HIIT) increases insulin-like growth factor-I (IGF-I) in sedentary aging men but not masters’ athletes: an observational study

Cited by 24 publications

References 31 publications

One session of high-intensity interval training (HIIT) every 5 days, improves muscle power but not static balance in lifelong sedentary ageing men

One session of high-intensity interval training (HIIT) every 5 days, improves muscle power but not static balance in lifelong sedentary ageing men

Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation

HIIT produces increases in muscle power and free testosterone in male masters athletes

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