Associations of insulin‐like growth factor‐I and insulin‐like growth factor binding protein‐3 with bone quality in the general adult population

Böker, J.; Völzke, Henry; Nauck, Matthias; Hannemann, Anke; Friedrich, Nele

doi:10.1111/cen.13588

Cited by 7 publications

(3 citation statements)

References 51 publications

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“…Accordingly, lower protein intake leads to lower IGF-1 (25,27) which in turn leads to a lower bone mass (25)(26)(27)(28) . This could result in a higher fracture risk, with studies finding a negative association between IGF-1 concentration and predicted fracture risk (25,29,30) . Correcting low-protein intake theoretically leads to a variety of musculoskeletal health benefits in older individuals ( Fig.…”

Section: Anabolic Associations Of Dietary Protein With Bone Healthmentioning

confidence: 99%

Dietary protein and bone health: towards a synthesised view

2020

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The present paper reviews published literature on the relationship between dietary protein and bone health. It will include arguments both for and against the anabolic and catabolic effects of dietary protein on bone health. Adequate protein intake provides the amino acids used in building and maintaining bone tissue, as well as stimulating the action of insulin-like growth factor 1, which in turn promotes bone growth and increases calcium absorption. However, the metabolism of dietary sulphur amino acids, mainly from animal protein, can lead to increased physiological acidity, which may be detrimental for bone health in the long term. Similarly, cereal foods contain dietary phytate, which in turn contains phosphate. It is known that phosphate consumption can also lead to increased physiological acidity. Therefore, cereal products may produce as much acid as do animal proteins that contain sulphur amino acids. The overall effect of dietary protein on physiological acidity, and its consequent impact on bone health, is extremely complex and somewhat controversial. The consensus is now moving towards a synthesised approach. Particularly, how anabolic and catabolic mechanisms interact; as well as how the context of the whole diet and the type of protein consumed is important.

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Section: Anabolic Associations Of Dietary Protein With Bone Healthmentioning

confidence: 99%

Dietary protein and bone health: towards a synthesised view

2020

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“…Research by Misra et al[32] showed that patients with AN manifest elevated growth hormone (GH) and low IGF-1 concentrations, suggesting some degree of resistance to GH. Since IGF-1 exerts stimulatory effects on osteoblasts,[33] it has been postulated that the low IGF-1 in patients with AN may contribute to their low bone density. [2834] Later studies have confirmed an association between IGF-1 and BMD in patients with AN independent of their BMI.…”

Section: What Factors Contribute To An-related Bone Disease?mentioning

confidence: 99%

Anorexia Nervosa and Osteoporosis: Pathophysiology and Treatment

Steinman

Shibli-Rahhal

2019

J Bone Metab

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Anorexia nervosa (AN) affects 2.9 million people, many of whom experience bone loss and increased fracture risk. In this article, we review data on the underlying pathophysiology of AN-related osteoporosis and possible approaches to disease management. Available research suggests that low body weight and decreased gonadal function are the strongest predictors of bone loss and fractures in patients with AN. Additionally, other metabolic disturbances have been linked to bone loss, including growth hormone resistance, low leptin concentrations, and hypercortisolemia, but those correlations are less consistent and lack evidence of causality. In terms of treatment of AN-related bone disease, weight gain has the most robust impact on bone mineral density (BMD). Restoration of gonadal function seems to augment this effect and may independently improve BMD. Bisphosphonates, insulin-like growth factor 1 supplementation, and teriparatide may also be reasonable considerations, however need long-term efficacy and safety data.

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“…IGFBP-3 is a binding protein of IGF-I, which regulates the synthesis of IGF-I, prolongs the half-life of IGF-I in bone metabolism, regulates the metabolism of vitamin D, and promotes the utilization of calcium [6]. According to a study, circulating levels of IGF-I and IGFBP-3 were significantly lower in older adults than in the young population, and a low circulating IGF-I and IGFBP-3 level was associated with osteoporosis [7]. However, other researchers reported that IGFBP-3 is a potent inhibitor of IGF-Imedicated DNA synthesis [8], indicating that IGFBP-3 could counteract the physiological function of IGF-I to a certain extent.…”

Section: Introductionmentioning

confidence: 99%

Circulating IGFBP-3 and Interleukin 6 as Predictors of Osteoporosis in Postmenopausal Women: A Cross-Sectional Study

Shi

Jiang

Rao

et al. 2023

Mediators of Inflammation

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Objective. To explore the relationship between circulating IGFBP-3, IL-6, and bone mineral density and the potential diagnostic role of circulating IGFBP-3 and IL-6 in postmenopausal women with osteoporosis. Methods. Eighty-five postmenopausal women at Soochow University’s First Affiliated Hospital, Osteoporosis and Menopause Clinics, were recruited. Forty-five of 85 women were diagnosed with osteoporosis. Circulating IL-6, PTH, 1,25(OH)2D3, osteocalcin (OST), IGF-1, IGFBP-3, and bone mineral density (BMD) of the lumbar spine (LS) and femoral neck (FN) were measured in 40 ordinary and 45 osteoporotic women. A simple regression analysis calculated the correlation between age, BMD, IL-6, and IGFBP-3. Multiple stepwise regression analyses were conducted to determine which variables were independently related to BMD. The potential role of IGFBP-3 and IL-6 in the diagnosis of postmenopausal osteoporosis was predicted using the area under the receiver operating characteristic curve (ROC, AUC). Results. Age, years since menopause, and circulating IL-6, PTH, and IGFBP-3 were significantly higher in the osteoporosis group compared to the normal group. Osteoporotic women had substantially lower BMDs of the LS and FN than normal women. Age-related increases were found for IGFBP-3 and IL-6, whereas age-related decreases were observed for LS/FN BMD. IGFBP-3 and IL-6 were both negatively correlated with LS and FN BMD. Stepwise multiple regression analysis showed that IGFBP-3 and IL-6 were strong predictors of BMD in postmenopausal women. AUC cut-off values (IGFBP-3: 3.65, IL-6: 0.205) were best evaluated for the diagnosis of postmenopausal women with osteoporosis, and the AUC for circulating IGFBP-3 and IL-6 were 0.706 (95% CI 0.594–0.818) and 0.685 (95% CI 0.571–0.798), respectively. Conclusion. In this cross-sectional study of postmenopausal women, IGFBP-3 and IL-6 were negatively related to BMD. Circulating IGFBP-3 and IL-6 might be essential predictors of postmenopausal osteoporosis and can help predict osteoporotic fracture.

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Associations of insulin‐like growth factor‐I and insulin‐like growth factor binding protein‐3 with bone quality in the general adult population

Cited by 7 publications

References 51 publications

Dietary protein and bone health: towards a synthesised view

Dietary protein and bone health: towards a synthesised view

Anorexia Nervosa and Osteoporosis: Pathophysiology and Treatment

Circulating IGFBP-3 and Interleukin 6 as Predictors of Osteoporosis in Postmenopausal Women: A Cross-Sectional Study

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