Gelation behavior and supramolecular chirality of a BTA derivative in a deep eutectic solvent

Abstract

As novel solvents, the deep eutectic solvents (DESs) are non-toxic, easily producible and biocompatible, which is attractive for eutectogel fabrication. In this work, a benzene 1,3,5-tricarboxamide (BTA) derivative (substituted by...

Eutectic solvents and low molecular weight gelators for next-generation supramolecular eutectogels: a sustainable chemistry perspective

“…with the amide groups attached to the benzene ring via the carbonyl group) and C3 symmetric ( i.e. with three identical substituent groups) BTA homolog has been used by Zhang et al 110 The authors exploited the unique structural features of the BTA3 gelator to build supramolecular gels with the ChCl-PhAA 1 : 2 DES with well defined helicized columnar assemblies. The columnar architecture was the result of synergic action of three different factors: the threefold H-bond involving the amide functional groups, the intermolecular H-bond of the carboxylic acid groups at the end of the alkyl chain with the DES components, and the π–π stacking of the aromatic rings.…”

“…The authors report a detectable Cotton effect in the CD spectra of the eutectogel at 206 nm. 110 A possible explanation relies upon the chiral stacking – with either a P or M twist – of BTA3 mediated by the directional threefold H-bonds. Although the P and M columnar assemblies were generated randomly, further assembly of columns with the same twist mode (P or M) into fibers resulted in symmetry breaking, 121 thus leading to observable random CD signals.…”

Supramolecular Hydrophobic Eutectogels Based on Menthol-Thymol as Thermo- and pH-Responsive Drug Delivery Systems

“…A complementary approach to confine eutectic solvents in a three-dimensional nanoscale solid-like network, while retaining their original nature, is based on gelation by the molecular self-assembly of low-molecular weight gelators (LMWGs). ,− A supramolecular gel is formed as a result of noncovalent intermolecular interactions like hydrogen-bonding, π–π stacking, host–guest, and van der Waals interactions. , Since the formation of the gel matrix involves weak yet nonpermanent interactions, which often depend on the local chemical environment, these soft functional materials are highly sensitive to external stimuli such as pH, temperature change, or ionic strength . This allows for the design of stimuli-responsive systems for sustained drug delivery. − However, the complex structure and mechanical properties of the 3D gel network also affect the release kinetics of the loaded drugs.…”

Encapsulating eutectogels for stretchable humidity-resistant strain sensors

“…[1][2][3] In contrast to the ILs that suffer from high cost, inferior biocompatibility, and complicated fabrication processes, DESs have superior properties of low cost, good biocompatibility, and easy synthesis. [4][5][6] Recently, eutectogels synthesized by embedding DESs into solid frameworks, such as polymer matrices, have been gaining more and more attention. 2,7 With the rapid development of stretchable ionotronics, 8 eutectogels open interesting perspectives for applications such as wearable sensors, [9][10][11][12][13][14][15] triboelectric nanogenerators, 16 supercapacitors, 17 soft batteries, 18 and stretchable adhesives, 19,20 although additional efforts are still needed to improve their mechanical and electrical performances.…”