Gelatin microspheres: influence of preparation parameters and thermal treatment on chemico-physical and biopharmaceutical properties

Incorporation of PLGA nanoparticles into porous chitosan–gelatin scaffolds: Influence on the physical properties and cell behavior

“…G is a protein derived from collagen, and it has been frequently applied in artificial skin, bone grafts, and scaffolds for tissue engineering (Esposito et al, 1996;Kawai et al, 2000;Zhao et al, 2002;Ito et al, 2003;Chang et al, 2003). Its wide use in the biomedical field is motivated by the presence of Arg-Gly-Asp (RGD)-like sequences that promote cell adhesion and migration (Shen et al, 2000).…”

In vivodrug release and antibacterial properties of vancomycin loaded hydroxyapatite/chitosan composite

“…The development of new drug dosage forms focuses on enhanced bioavailability, greater efficiency, lower toxicity, and controlled release (Narayani & Panduranga, 1996;Esposito et al, 1966;Cortesi et al, 1998;Wei et al, 2008;Fischer et al, 2009;Vivero-Escoto et al, 2009). Recently, mesoporous materials become one of hotspots in the drug delivery systems, especially as implantable local-delivery devices for bone tissue repair (ValletRegí et al, 2007;Manzano & Vallet-Regi, 2010).…”

Lung-targeted delivery system of curcumin loaded gelatin microspheres

“…Glutaraldehyde was chosen as the cross-linking agent because it could solidify in neutral conditions while formaldehyde could only solidify completely in basic conditions, in which curcumin was very easy to decompose (Zeng et al, 1996, Esposito et al, 1996. The function of the cross-linking agent was to solidify and precipitate the microspheres from water, improve the thermal and mechanical stability of the microspheres under physiological conditions, and control the rate of degradation in vivo (Tabata et al, 1999).…”