Incorporation of PLGA nanoparticles into porous chitosan–gelatin scaffolds: Influence on the physical properties and cell behavior

Localised controlled release of simvastatin from porous chitosan–gelatin scaffolds engrafted with simvastatin loaded PLGA-microparticles for bone tissue engineering application

“…In addition, we showed that the incorporation of PLGA nanoparticles within CH-G scaffolds resulted in scaffolds with enhanced mechanical properties, without affecting its cell attachment properties [26].…”

Bone repair: New developments in growth factor delivery systems and their mathematical modeling

“…The addition of PLGA to the chitosan also decreased its swelling. Mechanical tests also indicated that a 33.3% PLGA content is associated with the maximal compressive modulus [90]. Thus PLGA can be used to control the porosity of the scaffold and its mechanical strength.…”

“…Thus, they may be released by different mechanisms. Nandagiri et al [90] investigated the influence of the PLGA microparticle content (16.6%, 33.3% or 66.6% w/w) in a chitosan-gelatin scaffold. A scaffold containing 16.6% and 33.3% PLGA had a similar pore size distribution (100-150 μm) and mean pore size, while a scaffold with 66.6% PLGA had a pore size over 150 μm.…”

Biocompatibility of biomimetic multilayered alginate–chitosan/β-TCP scaffold for osteochondral tissue

“…The water absorption capacity of the separately manufactured layers and TLS were determined after immersion of preweighted cylindrical scaffolds with 9 mm diameter and approximately 4 mm thickness in 3 ml of PBS (pH 7.4) and the swollen scaffolds weights were determined after removal of the surface liquid using filter paper [19,20]. The water absorption percent was calculated by the following equation:…”