Gelatin-based microspheres crosslinked with glutaraldehyde and rutin oriented to cosmetics

Graziola, Fabiana; Cândido, Thalita Marcílio; Oliveira, Camila Areias de; Peres, Daniela D'Almeida; Issa, Michele Georges; Mota, Joana Portugal; Rosado, Catarina; Consiglieri, Vladi Olga; Kaneko, Telma Mary; Velasco, Maria Valéria Robles; Baby, André Rolim

doi:10.1590/s1984-82502016000400004

Cited by 32 publications

(18 citation statements)

References 25 publications

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“…Polymeric and lipid nanoparticles nanoparticles are the most studied nanoformulations for rutin. Then, we categorized the major nanoformulations of rutin as follow: Polymeric nanoparticles, lipid‐based nanoparticles, molecular complexes and the other types of nanoparticles (Graziola et al, 2016; Júlio et al, 2019; Pandey et al, 2018; Ramaswamy et al, 2017; Shahi et al, 2019).…”

Section: Nanotechnology Approaches For Improving Rutin Effectsmentioning

confidence: 99%

Therapeutic benefits of rutin and its nanoformulations

Negahdari

Bohlouli

Sharifi

et al. 2020

Phytotherapy Research

125

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Background Rutin as a natural flavonoid compound has revealed an extensive range of therapeutic potentials. Purpose The current paper is focused on the numerous studies on rutin nanoformulations regarding its broad spectrum of therapeutic potentials. Study and methods A review was conducted in electronic databases (PubMed) to identify relevant published literature in English. No restrictions on publication date were imposed. Results The literature search provided 7,078 results for rutin. Among them, 25 papers were related to the potential biological activities of rutin nanoformulations. Polymeric nanoparticles were the most studied nanoformulations for rutin (14 titles) and lipid nanoparticles (5 titles) were in second place. The reviewed literature showed that rutin has been used as an antimicrobial, antifungal, and anti‐allergic agent. Improving the bioavailability of rutin using novel drug‐delivery methods will help the investigators to use its useful effects in the treatment of various chronic human diseases. Conclusion It can be concluded that the preparation of rutin nanomaterials for the various therapeutic objects confirmed the enhanced aqueous solubility as well as enhanced efficacy compared to conventional delivery of rutin. However, more investigations should be conducted to confirm the improved bioavailability of the rutin nanoformulations.

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Section: Nanotechnology Approaches For Improving Rutin Effectsmentioning

confidence: 99%

Therapeutic benefits of rutin and its nanoformulations

Negahdari

Bohlouli

Sharifi

et al. 2020

Phytotherapy Research

125

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“…Therefore, the applications of the gelatin hydrogel in vivo are limited, due to its poor mechanical properties, rapid degradation rate, and low transition temperatures. To obtain suitable mechanical strength and stable gelatin hydrogel, various chemical crosslinking methods have been used, such as glutaraldehyde [ 14 , 15 ] and diisocyanate [ 16 , 17 ]. However, most of the chemical crosslinkers are toxic, and their use as cell-laden matrices for tissue engineering application is limited.…”

Section: Introductionmentioning

confidence: 99%

Development of a Photo-Crosslinking, Biodegradable GelMA/PEGDA Hydrogel for Guided Bone Regeneration Materials

et al. 2018

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Gelatin-based hydrogel, which mimics the natural dermal extracellular matrix, is a promising tissue engineering material. However, insufficient and uncontrollable mechanical and degradation properties remain the major obstacles for its application in medical bone regeneration material. Herein, we develop a facile but efficient strategy for a novel hydrogel as guided bone regeneration (GBR) material. In this study, methacrylic anhydride (MA) has been used to modify gelatin to obtain photo-crosslinkable methacrylated gelatin (GelMA). Moreover, the GelMA/PEGDA hydrogel was prepared by photo-crosslinking GelMA and PEGDA with photoinitiator I2959 under UV treatment. Compared with the GelMA hydrogel, the GelMA/PEGDA hydrogel exhibits several times stronger mechanical properties than pure GelMA hydrogel. The GelMA/PEGDA hydrogel shows a suitable degradation rate of more than 4 weeks, which is beneficial to implant in body. In vitro cell culture showed that osteoblast can adhere and proliferate on the surface of the hydrogel, indicating that the GelMA/PEGDA hydrogel had good cell viability and biocompatibility. Furthermore, by changing the quantities of GelMA, I2959, and PEGDA, the gelation time can be controlled easily to meet the requirement of its applications. In short, this study demonstrated that PEGDA enhanced the performance and extended the applications of GelMA hydrogels, turning the GelMA/PEGDA hydrogel into an excellent GBR material.

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“…Considering the use of protein-based bioactives, Graziola and co-workers (2016), observed that gelatin at 5.0% w/w, as an amorphous raw-material, was able to improve the SPF of mineral oil-based dispersions containing 6.0% w/w of benzophenone-3 or 7.5% of ethylhexyl methoxycinnamate, from 2.8 to 4.1 and 6.4 to 8.4, respectively. The critical wavelength (nm) of those dispersions was not affected, being kept below 354.5 nm, even in the UVA filter (benzophenone-3) presence (Graziola et al, 2016). Stiefel and Schwack (2014), identified UV spectra alterations of the octocrylene incubated at 37 °C with bovine serum albumin (BSA) compared to the UVB filter alone.…”

Section: Resultsmentioning

confidence: 99%

Hydrolyzed collagen interferes with in vitro photoprotective effectiveness of sunscreens

Peres

Hubner

Oliveira

et al. 2017

Braz. J. Pharm. Sci.

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The chronological skin aging is a progressive and natural process with genetic and physiological changes. However, ultraviolet (UV) radiation may accelerate the oxidative stress, generating carcinogenesis and photoaging. Natural compounds and their applications are considered a trend in the cosmetic market. The protein-based film-forming compounds play an important role, once it collaborates for the better distribution of sunscreens on the skin. Here we investigated the in vitro photoprotective effectiveness of sunscreens containing the hydrolyzed collagen associated with UVA, UVB and/or inorganic filters. Sunscreens were developed with octocrylene (7.5%), butyl methoxydibenzoylmethane (avobenzone) (3.0%) and/or titanium dioxide (5.0%), associated or not with the hydrolyzed collagen (3.0%). In vitro photoprotective effectiveness was determined in a Labsphere ® UV2000S by the establishment of the sun protection factor (SPF) and critical wavelength (nm) values. Physicochemical and organoleptic characteristics were also assayed. The hydrolyzed collagen subjectively improved the formulation sensory characteristics. However, this bioactive compound led to a decrease of the SPF values of the photoprotective formulations containing octocrylene alone and octocrylene + butyl methoxydibenzoylmethane + TiO 2. This inadequate interaction may be considered during the development of new sunscreens intended to contain protein-based components.

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Gelatin-based microspheres crosslinked with glutaraldehyde and rutin oriented to cosmetics

Cited by 32 publications

References 25 publications

Therapeutic benefits of rutin and its nanoformulations

Therapeutic benefits of rutin and its nanoformulations

Development of a Photo-Crosslinking, Biodegradable GelMA/PEGDA Hydrogel for Guided Bone Regeneration Materials

Hydrolyzed collagen interferes with in vitro photoprotective effectiveness of sunscreens

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