Gelatin-Based Hydrogels

Rashid, Taslim Ur; Sharmeen, Sadia; Biswas, Samit; Ahmed, Tanvir; Mallik, Abul K.; Shahruzzaman, Md.; Sakib, Md. Nurus; Haque, Papia; Rahman, Mohammed Mizanur

doi:10.1007/978-3-319-77830-3_53

Cited by 21 publications

(16 citation statements)

References 141 publications

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“…33−36 Similarly, gelatin is also a biocompatible biopolymer with hydration properties and exhibits antimicrobial properties. 37 A reduction of pig platelet adhesion on agarose has been observed. 38 However, the response of human platelets on hydrogels, especially formed by agarose, has been insufficiently investigated.…”

Section: Introductionmentioning

confidence: 91%

“…The steric repulsion by the hydrated chains in hydrogels contributes to their bioinertness . Agarose, a polymer of natural origin, contains hydroxyl groups that contribute to the overall antifouling properties of the hydrogel. − Similarly, gelatin is also a biocompatible biopolymer with hydration properties and exhibits antimicrobial properties . A reduction of pig platelet adhesion on agarose has been observed .…”

Section: Introductionmentioning

confidence: 99%

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Controlling Surface-Induced Platelet Activation by Agarose and Gelatin-Based Hydrogel Films

et al. 2021

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Platelet-surface interaction is of paramount importance in biomedical applications as well as in vitro studies. However, controlling platelet-surface activation is challenging and still requires more effort as they activate immediately when contacting with any nonphysiological surface. As hydrogels are highly biocompatible, in this study, we developed agarose and gelatin-based hydrogel films to inhibit platelet-surface adhesion. We found promising agarose films that exhibit higher surface wettability, better controlled-swelling properties, and greater stiffness compared to gelatin, resulting in a strong reduction of platelet adhesion. Mechanical properties and surface wettability of the hydrogel films were varied by adding magnetite (Fe 3 O 4 ) nanoparticles. While all of the films prevented platelet spreading, films formed by agarose and its nanocomposite repelled platelets and inhibited platelet adhesion and activation stronger than those of gelatin. Our results showed that platelet-surface activation is modulated by controlling the properties of the films underneath platelets and that the bioinert agarose can be potentially translated to the development of platelet storage and other medical applications.

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Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Controlling Surface-Induced Platelet Activation by Agarose and Gelatin-Based Hydrogel Films

et al. 2021

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“…Numerous distinctive techniques have been practiced for years for physical and chemical cross-linking of hydrogels, such as by adding free-radical building blocks, cross-linking with aldehydes, addition and condensation reaction, and radiation and enzymes assisted cross-linking. , Among these methods, aldehyde based cross-linking and condensation reaction are the two most used techniques to form chemically cross-linked hydrogels. , Owing to their multifunctional properties and simple operation, several techniques have already been used to synthesize different structured gelatin-based hydrogels in nanomedicine applications. These preparation techniques, advantageous properties, and their applications in nanomedicine are discussed in the following sections and summarized in Table .…”

Section: Preparation Of Gelatin-based Hydrogelsmentioning

confidence: 99%

Hybrid Gelatin Hydrogels in Nanomedicine Applications

Salahuddin

Wang

Sangian

et al. 2021

ACS Appl. Bio Mater.

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Gelatin based hydrogels are often incorporated with supporting materials such as chitosan, poly(vinyl alcohol), alginate, carbon nanotubes, and hyaluronic acid. These hybrid materials are specifically of interest in diversified nanomedicine fields as they exhibit unique physicochemical properties, antimicrobial activity, biodegradability, and biocompatibility. The applications include drug delivery, wound healing, cell culture, and tissue engineering. This paper reviews the various up-to-date methods to fabricate gelatin-based hydrogels, including UV photo-cross-linking, electrospinning, and 3D bioprinting. This paper also includes physical, chemical, mechanical, and biocompatibility characterization studies of several hybrid gelatin hydrogels and discusses their relevance in nanomedicine based applications. Challenges associated with the fabrication of hybrid materials for nanotechnology implementation, specifically in nanomedicine development, are critically discussed, and some future recommendations are provided.

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“…Similarly, temperature, ionic strength, pH, or concentration also influence gelatin behavior. For instance, hydrogels can form spontaneously upon cooling the gelatin solution, in a sol-gel transition, or through physical and chemical modifications [45]. The denaturation of collagen confers gelatin with similar chemical and mechanical properties to those of the related collagen scaffolds.…”

Section: Three-dimensional (3d) Ecm-mimicking Scaffolds: Materialsmentioning

confidence: 99%

Modeling the Mechanobiology of Cancer Cell Migration Using 3D Biomimetic Hydrogels

Morales

Cortés-Domínguez

Ortiz‐de‐Solórzano

2021

Gels

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Understanding how cancer cells migrate, and how this migration is affected by the mechanical and chemical composition of the extracellular matrix (ECM) is critical to investigate and possibly interfere with the metastatic process, which is responsible for most cancer-related deaths. In this article we review the state of the art about the use of hydrogel-based three-dimensional (3D) scaffolds as artificial platforms to model the mechanobiology of cancer cell migration. We start by briefly reviewing the concept and composition of the extracellular matrix (ECM) and the materials commonly used to recreate the cancerous ECM. Then we summarize the most relevant knowledge about the mechanobiology of cancer cell migration that has been obtained using 3D hydrogel scaffolds, and relate those discoveries to what has been observed in the clinical management of solid tumors. Finally, we review some recent methodological developments, specifically the use of novel bioprinting techniques and microfluidics to create realistic hydrogel-based models of the cancer ECM, and some of their applications in the context of the study of cancer cell migration.

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Gelatin-Based Hydrogels

Cited by 21 publications

References 141 publications

Controlling Surface-Induced Platelet Activation by Agarose and Gelatin-Based Hydrogel Films

Controlling Surface-Induced Platelet Activation by Agarose and Gelatin-Based Hydrogel Films

Hybrid Gelatin Hydrogels in Nanomedicine Applications

Modeling the Mechanobiology of Cancer Cell Migration Using 3D Biomimetic Hydrogels

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