Gelam Honey Attenuates Carrageenan-Induced Rat Paw Inflammation via NF-κB Pathway

Hussein, Saba Zuhair; Yusoff, Kamaruddin Mohd; Makpol, Suzana; Yusof, Yasmin Anum Mohd

doi:10.1371/journal.pone.0072365

Cited by 88 publications

(67 citation statements)

References 68 publications

(69 reference statements)

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“…Mohamed et al have shown that Tualang honey contains highly phenolic compounds that possess relatively good anti-oxidant activity. In an animal model, a topical dressing of Tualang honey showed a positive effect for treating full-thickness burn wounds [41,50,51]. As previously reported, Gelam honey has anti-oxidative and radical scavenging activities, which are mainly attributed to its phenolic content.…”

Section: Anti-inflammatory Effectsmentioning

confidence: 61%

Honey and its Anti-Inflammatory, Anti-Bacterial and Anti-Oxidant Properties

Vallianou¹,

Gounari²,

Àlex³

et al. 2014

General Med

121

113

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Honey mainly consists of sugars and water. Apart from sugars, honey also contains several vitamins, especially B complex and vitamin C, together with a lot of minerals. Some of the vitamins found in honey include ascorbic acid, pantothenic acid, niacin and riboflavin; while minerals such as calcium, copper, iron, magnesium, manganese, phosphorus, potassium and zinc are also present. Honey has been used for its healing, nutritional and therapeutic properties since ancient times. Its antibacterial potentials even against multi-drug resistant bacteria, such as Staphylococcus aureus, Pseudomonas aeruginosa and Acinetobacterbaumanni have been proved. Honey is well known for its anti-inflammatory and antioxidant capacities, which may be useful for the prevention of chronic inflammatory process like atherosclerosis, diabetes mellitus and cardiovascular diseases. The antibacterial, antiinflammatory and antioxidant properties of honey will be reviewed here.

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Section: Anti-inflammatory Effectsmentioning

confidence: 61%

Honey and its Anti-Inflammatory, Anti-Bacterial and Anti-Oxidant Properties

Vallianou¹,

Gounari²,

Àlex³

et al. 2014

General Med

121

113

View full text Add to dashboard Cite

show abstract

“…A statistically no significant difference (P>0.01) was present between saline/water and saline/honey group in terms of the rate of proliferation and antiapoptosis. This is because honey is non-cytotoxic to normal cells [31].…”

Section: Discussionmentioning

confidence: 99%

Effects of Kurdistan Honey on the Tongue of Chemotherapy Treated Albino Rats (Immunohistochemical Study)

Refai¹

2014

J Cytol Histol

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“…The scores were defined as follows: 0 = no inflammation, 1 = mild inflammation, 2 = mild/moderate inflammation, 3 = moderate inflammation, 4 = moderate/ severe inflammation and 5 = severe inflammation. 27,28…”

Section: Histopathological Evaluationmentioning

confidence: 99%

<p>Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation</p>

Aman¹,

Hashim²,

Meshali³

2020

IJN

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Purpose: Clove essential oil is a phytochemical possessing a vast array of biological activities. Nevertheless, fabricating nano topical delivery systems targeted to augment the anti-inflammatory activity of the oil has not been investigated so far. Accordingly, in this study, controlled release nanoparticulate systems, namely nanoemulgel and nanofibers (NFs), of the oil were developed to achieve such goal. Methods: The nanoemulsion was incorporated in the hydrogel matrix of mixed biopolymerschitosan, guar gum and gum acaciato formulate nanoemulsion-based nanoemulgel. Taguchi's model was adopted to evaluate the effect of independently controlled parameters, namely, the concentration of chitosan (X 1), guar gum (X 2), and gum acacia (X 3) on different dependently measured parameters. Additionally, the nanoemulsion-based NFs were prepared by the electrospinning technique using polyvinyl alcohol (PVA) polymer. Extensive in vitro, ex vivo and in vivo evaluations of the aforementioned formulae were conducted. Results: Both Fourier transform-infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) established the complete dispersion of the nanoemulsion in the polymeric matrices of the prepared nanoemulgel and NFs. The ex vivo skin permeation data of clove essential oil from the prepared formulations showed that NFs can sustain its penetration through the skin comparably with nanoemulgel. Topical treatment with NFs (once application) and nanoemulgel (twice application) evoked a marvelous in vivo anti-inflammatory activity against croton oil-induced mouse skin inflammation model when compared with pure clove essential oil along with relatively higher efficacy of medicated NFs than that of medicated nanoemulgel. Such prominent anti-inflammatory activity was affirmed by histopathological and immunohistochemical examinations. Conclusion: These results indicated that nanoemulsion-based nanoemulgel and nanoemulsion-based NFs could be introduced to the phytomedicine field as promising topical delivery systems for effective treatment of inflammatory diseases instead of nonsteroidal antiinflammatory drugs that possess adverse effects.

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Gelam Honey Attenuates Carrageenan-Induced Rat Paw Inflammation via NF-κB Pathway

Cited by 88 publications

References 68 publications

Honey and its Anti-Inflammatory, Anti-Bacterial and Anti-Oxidant Properties

Honey and its Anti-Inflammatory, Anti-Bacterial and Anti-Oxidant Properties

Effects of Kurdistan Honey on the Tongue of Chemotherapy Treated Albino Rats (Immunohistochemical Study)

<p>Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation</p>

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