Effects of Kurdistan Honey on the Tongue of Chemotherapy Treated Albino Rats (Immunohistochemical Study)

Refai, Ali Sultan Al

doi:10.4172/2157-7099.1000272

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…The findings of the present study were in line with other studies that reported similar changes in tongue mucosa of experimental rats induced by other cytotoxic drugs such as 5‐Fluorouracil and methotrexate . In addition, a more recent study showed that irinotecan administration in rats led to an intestinal mucosal damage that was manifested by disorganized epithelial architecture, epithelial damage, atrophy of the villi and inflammatory cellular infiltration.…”

Section: Discussionsupporting

confidence: 93%

Effect of irinotecan on the tongue mucosa of juvenile male albino rat at adulthood

Ibrahim

Elwan

2019

Int J Experimental Path

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Summary Irinotecan is one of the most important anti‐tumour drugs against a broad spectrum of malignancies, but is known to be associated with possible oral complications. The aim of the present study was to evaluate the effect of irinotecan on the tongue mucosa of juvenile male albino rat at adulthood using different histological and immunohistochemical methods. Twenty juvenile male albino rats were divided equally into two groups: control and irinotecan‐treated group (single injection of 200 mg irinotecan/kg, then kept for four weeks without treatment). The tongue specimens were processed for light microscopy and scanning electron microscopy. The irinotecan‐treated group showed statistically significant shortening and thinning of the lingual papillae. There was loss of the normal appearance of the filiform papillae with focal cell loss alternating with areas of hyperkeratosis. Focal separation of the keratin layer, some nuclear changes and vacuolation of some epithelial cells were detected. Dilated congested blood vessels and mild mononuclear cellular infiltration were encountered. Atrophic fungiform papillae with ill‐defined taste bud cells were observed. A statistically significant decrease in the pattern of Ki67 immunohistochemical staining reaction was detected in comparision to the control group. Scanning electron microscopy revealed different signs of atrophy of the tongue papillae. Focal areas of desquamation of lingual papillae were observed revealing some filiform papillae with desquamated surface, bisected tips and evident thinning. Some extravasated red blood cells could be detected. Thus irinotecan caused significant morphological and morphometrical alterations of the tongue mucosa in particularly the filiform papillae.

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Section: Discussionsupporting

confidence: 93%

Effect of irinotecan on the tongue mucosa of juvenile male albino rat at adulthood

Ibrahim

Elwan

2019

Int J Experimental Path

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“…The affected cells revealed vacuolated cytoplasm with condensed pyknotic nuclei. Our results were in harmony with Al Refai [ 30 ]. These degenerative changes could be due to the inhibition of topoisomerase I, which results in DNA damage and fragmentation.…”

Section: Discussionsupporting

confidence: 93%

Study of the Possible Alleviated Role of Atorvastatin on Irinotecan‐Induced Lingual Mucosal Damage: Histological and Molecular Study

Arafat

El-Khair

Elsamanoudy

et al. 2021

Oxidative Medicine and Cellular Longevity

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Background. Oral mucositis is the most debilitating and troublesome adverse effect of irinotecan (CPT-11) treatment. It adversely affects the patient quality of life. The aim of this work was to study the histological, immunohistochemical, and molecular changes in the oral mucosa by CPT-11 and the possible alleviated role of atorvastatin. Methods. Rats were randomly divided into control, CPT-11-treated group, and CPT-11+ atorvastatin-treated group. At the end of the experiment, the anterior two-thirds of the tongue was dissected out and divided into two parts: one part for light microscopic examination and the second for molecular study. Results. CPT-11-treated group revealed loss of normal mucosal organization, areas of ulceration and inflammation, and loss of architecture of lingual papillae. A significant decrease in immunohistochemical and molecular gene expression of Ki-67 and antiapoptotic Bcl-2 levels was observed. A significant increase in NF-κB immunohistochemical and mRNA gene expression level and a nonsignificant increase in Nrf2 gene expression were detected. Coadministration of atorvastatin showed remarkable improvement in the histopathological picture with a significant increase in Ki-67 and Bcl-2, a significant decrease in NF-κB protein and gene expression, and a significant increase in Nrf2 gene expression. Conclusion. Atorvastatin substantially attenuates CPT-11-induced oral mucositis through the initiation of the antiapoptotic gene, modulation of the inflammatory, and antioxidant gene expression.

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Possible Protective Effect of Ginger on the Buccal Mucosa of Methotrexate Treated Male Albino Rats (Molecular and Histological Evaluation)

Shredah¹,

Deeb²

2017

Egyptian Dental Journal

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Effects of Kurdistan Honey on the Tongue of Chemotherapy Treated Albino Rats (Immunohistochemical Study)

Cited by 3 publications

References 23 publications

Effect of irinotecan on the tongue mucosa of juvenile male albino rat at adulthood

Effect of irinotecan on the tongue mucosa of juvenile male albino rat at adulthood

Study of the Possible Alleviated Role of Atorvastatin on Irinotecan‐Induced Lingual Mucosal Damage: Histological and Molecular Study

Possible Protective Effect of Ginger on the Buccal Mucosa of Methotrexate Treated Male Albino Rats (Molecular and Histological Evaluation)

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