Gel network comprising UV crosslinked PLGA-b-PEG-MA nanoparticles for ibuprofen topical delivery

Eroğlu, İpek; Gultekinoglu, Merve; Bayram, Cem; Erikçi, Açelya; Ciftci, Samiye Yabanoglu; Aksoy, Eda Ayşe; Ulubayram, Kezban

doi:10.1080/10837450.2019.1643880

Cited by 10 publications

(11 citation statements)

References 45 publications

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“…Ibuprofen (IBUP), a non-steroidal anti-inflammatory drug (NSAID), also known as an analgesic and antipyretic agent, acts as a reversible inhibitor for cyclooxygenase (COX-1 and COX-2) enzymes through steric hindrance, thus reducing the level of prostaglandins (resulting in diminution of pain, fever and acute inflammatory reactions) [ 40 , 41 ]. IBUP can be used for the fabrication of unconventional and effective polymer–drug conjugate systems [ 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

et al. 2021

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To modulate the biofunctionality of implantable medical devices commonly used in clinical practice, their surface modification with bioactive polymeric coatings is an attractive and successful emerging strategy. Biodegradable coatings based on poly(lactic acid-co-glycolic acid), PLGA, represent versatile and safe candidates for surface modification of implantable biomaterials and devices, providing additional tunable ability for topical delivery of desired therapeutic agents. In the present study, Ibuprofen-loaded PLGA coatings (PLGA/IBUP) were obtained by using the dip-coating and drop-casting combined protocol. The composite materials demonstrated long-term drug release under biologically simulated dynamic conditions. Reversible swelling phenomena of polymeric coatings occurred in the first two weeks of testing, accompanied by the gradual matrix degradation and slow release of the therapeutic agent. Irreversible degradation of PLGA coatings occurred after one month, due to copolymer’s hydrolysis (evidenced by chemical and structural modifications). After 30 days of dynamic testing, the cumulative release of IBUP was ~250 µg/mL. Excellent cytocompatibility was revealed on human-derived macrophages, fibroblasts and keratinocytes. The results herein evidence the promising potential of PLGA/IBUP coatings to be used for surface modification of medical devices, such as metallic implants and wound dressings.

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Section: Introductionmentioning

confidence: 99%

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

et al. 2021

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Section: Nir-responsive Drug Delivery Nanoplatforms For Oa Therapymentioning

confidence: 99%

“…NIR light-responsive medication release platforms have gained increasing interest among the various light-responsive drug delivery platforms [125][126][127] for OA therapy. Three types of light are frequently utilized in photo-responsive therapies: ultraviolet (UV) (200-400 nm), [126] visible (Vis) (400-700 nm), [125] and NIR (700-1300 nm). [127] NIR has a greater tissue penetration depth than UV or Vis, which is necessary to effectively penetrate joints and achieve the intended regulated level of drug release in the joint cavity.…”

Section: Nir-responsive Drug Delivery Nanoplatforms For Oa Therapymentioning

confidence: 99%

Stimulus‐Responsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy

Jiang

Zhang

2023

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Fundamentally degenerative, OA represents a considerably negative impact on the quality of life. [1,2] With an increasingly aging global population, greater numbers of OA patients are representing a clear increase in economic and societal burden. OA is primarily characterized by the degeneration or deterioration of articular cartilage. [3] More specifically, as a result of the excessive recruitment of inflammatory cells at the joint site, [4] matrix metalloproteinase (MMP) [5] and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) [6] are overexpressed during the development of OA, which leads to the destruction of the collagen II network and glycosaminoglycan (GAG). Articular cartilage dysfunction and degradation then eventually result, often presenting with permanent pathologic alterations to the entire joint.Current pharmacological treatments, (primarily focused on pain relief and antiinflammation), and/or surgery, (including microfracture surgery and joint replacement), are the most conventional therapeutic approaches for OA. [1,7] There are several disadvantages to these conventional approaches. Whilst microfracture surgery provides a measure of relief and functional recovery of the smaller-scale joint defects through the local generation of fibrocartilage from bone marrow obtained from the subchondral bone, due to the lower abrasion-resistance ability of fibrocartilage this method is often unsuitable to provide long-term relief, or for situations where large-scale defects have occurred. [8] A number of clinical strategies of joint replacement, including osteochondral autografts or allografts, are also limited by the restricted availability of donor grafts or by complications requiring secondary surgery. [9] Along with the continued development of surgical treatments, more advanced therapeutic methods have also been developed for OA surgery. These include ACI (autologous chondrocyte implantation) and MACI (matrix-induced autologous chondrocyte implantation). However, for ACI, the viability and loss of chondrocytes during the planting procedure seem to be an unavoidable problem. MACI was developed as a potential solution to this, where the in vitro use of a biodegradable (collagen matrix membrane) material as a temporary scaffold for the pre-plantation of chondrocytes could effectively lessen the loss of cells during the process of transplantation. However, for patients of more advanced ages or with too large an area of injury to the cartilage, MACI remains an unsuitable therapeutic approach.Osteoarthritis (OA) is one of the most prevalent age-related degenerative diseases. With an increasingly aging global population, greater numbers of OA patients are providing clear economic and societal burdens. Surgical and pharmacological treatments are the most common and conventional therapeutic strategies for OA, but often fall considerably short of desired or optimal outcomes. With the development of stimulus-responsive nanoplatforms has come the potential for improved therapeutic strategies for...

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“…Regardless of the great number of active compounds that could be considered as therapeutics for promoting wound healing, the wound inflammatory environment inhibits their activity to improve healing, with a limited number of candidates proving clinical effects [1,2]. Analgesics such as morphine [138], ibuprofen [139,140], or lidocaine [141,142] are of significant interest in extensive burns, infected wounds, or in palliative medicine [1,143]. Additionally, hydrogels may also deliver growth factors [1,144,145], stem cells [2,146], peptides [147][148][149], and various drugs, such as anti-inflammatory drugs [144,150,151], amino acids [152], antioxidants [70,153], vitamins [154,155] and nutrients [135,156], which may decrease the inflammatory reaction, nourish the wound tissue, and promote wound healing [119,126].…”

Section: Active Hydrogels Based On Growth Factors Cytokines and Cells For Wound Dressingsmentioning

confidence: 99%

Hydrogel Dressings for the Treatment of Burn Wounds: An Up-To-Date Overview

2020

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Globally, the fourth most prevalent devastating form of trauma are burn injuries. Ideal burn wound dressings are fundamental to facilitate the wound healing process and decrease pain in lower time intervals. Conventional dry dressing treatments, such as those using absorbent gauze and/or absorbent cotton, possess limited therapeutic effects and require repeated dressing changes, which further aggravate patients’ suffering. Contrariwise, hydrogels represent a promising alternative to improve healing by assuring a moisture balance at the burn site. Most studies consider hydrogels as ideal candidate materials for the synthesis of wound dressings because they exhibit a three-dimensional (3D) structure, which mimics the natural extracellular matrix (ECM) of skin in regard to the high-water amount, which assures a moist environment to the wound. There is a wide variety of polymers that have been used, either alone or blended, for the fabrication of hydrogels designed for biomedical applications focusing on treating burn injuries. The aim of this paper is to provide an up-to-date overview of hydrogels applied in burn wound dressings.

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Gel network comprising UV crosslinked PLGA-b-PEG-MA nanoparticles for ibuprofen topical delivery

Cited by 10 publications

References 45 publications

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

Stimulus‐Responsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy

Hydrogel Dressings for the Treatment of Burn Wounds: An Up-To-Date Overview

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