Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

Abstract

To modulate the biofunctionality of implantable medical devices commonly used in clinical practice, their surface modification with bioactive polymeric coatings is an attractive and successful emerging strategy. Biodegradable coatings based on poly(lactic acid-co-glycolic acid), PLGA, represent versatile and safe candidates for surface modification of implantable biomaterials and devices, providing additional tunable ability for topical delivery of desired therapeutic agents. In the present study, Ibuprofen-loaded PLGA coatings (PLGA/IBUP) were obtained by using the dip-coating and drop-casting combined protocol. The composite materials demonstrated long-term drug release under biologically simulated dynamic conditions. Reversible swelling phenomena of polymeric coatings occurred in the first two weeks of testing, accompanied by the gradual matrix degradation and slow release of the therapeutic agent. Irreversible degradation of PLGA coatings occurred after one month, due to copolymer’s hydrolysis (evidenced by chemical and structural modifications). After 30 days of dynamic testing, the cumulative release of IBUP was ~250 µg/mL. Excellent cytocompatibility was revealed on human-derived macrophages, fibroblasts and keratinocytes. The results herein evidence the promising potential of PLGA/IBUP coatings to be used for surface modification of medical devices, such as metallic implants and wound dressings.

The dual-effects of PLGA@MT electrospun nanofiber coatings on promoting osteogenesis at the titanium–bone interface under diabetic conditions

“…Antibiotics or non-steroidal anti-inflammatory drugs (NSAIDs) have been placed into PLGA electrospun nanofibers to achieve a longlasting cure. [17][18][19] In this study, we consider applying the electrospun PLGA nanofiber coating as MT delivery system and anticipate the PLGA@MT-Ti enhance Ti-B interface osteointegration via dual effects of direct promotion on osteogenesis and suppressing of ROS overproduction under diabetic conditions, indicating a possibly beneficial application for resolving the problem of implant failure in diabetic patients.…”

“…Antibiotics or non-steroidal anti-inflammatory drugs (NSAIDs) have been placed into PLGA electrospun nanofibers to achieve a long-lasting cure. 17–19…”

Polymeric Coatings for Drug Delivery by Medical Devices

“…Biodegradable coatings based on poly (lactic acidco-glycolic acid), PLGA, are representing the versatile and safe candidates for surface modification of implantable biomaterials and devices, providing additional tunable ability for topical delivery of desired therapeutic agents. In O. Gherasim et al [109] study, Ibuprofen-loaded PLGA coatings (PLGA/IBUP) were generated by dip-coating and drop-casting combined protocol. The composite materials showed long-term drug release under biologically simulated dynamic conditions.…”

Laser Microperforation Assisted Drug-Elution from Biodegradable Films

“…For the base polymer, we chose a poly(lactic-co-glycolic acid) (PLGA), with the lactic/glycolic ratio being 50:50. It is a biocompatible and biodegradable polymer widely used in the coating of medical devices and in medicine in general, including particles and implants [ 2 , 14 , 15 ]. PLGA exhibits a strong tendency to hydrolysis and will degrade gradually in a course of a few months within the aquatic medium [ 16 ].…”