Laser Microperforation Assisted Drug-Elution from Biodegradable Films

Abstract

In a modern high-tech medicine, drug-eluting polymer coatings are actively used to solve a wide range of problems, including the prevention of post-surgery infection, inflammatory, restenosis, thrombosis and many other implant-associated complications. For major assumptions, the drug elution mechanism is considered mainly to be driven by the degradation of the polymer matrix. This process is very environmentally dependent, unpredictable and often leads to a non-linear drug release kinetic. In the present work, we demonstrate how the laser microperforation of cargo-loaded biodegradable films could be used as a tool to achieve zero-order release kinetics with different elution rates. The effects of the laser-induced hole’s diameter (10, 18, 22, 24 µm) and their density (0, 1, 2, 4 per sample) on release kinetic are studied. The linear dynamics of elution was measured for all perforation densities. Release rates were estimated to be 0.018 ± 0.01 µg/day, 0.211 ± 0.08 µg/day, 0.681 ± 0.1 µg/day and 1.19 ± 0.12 µg/day for groups with 0, 1, 2, 4 microperforations, respectively. The role of biodegradation of the polymer matrix is reduced only to the decomposition of the film over time with no major influence on elution rates.

In Vivo Laser-Induced Vasoactive Microenvironmental Setting via a Stimuli-Responsive Microstructured Depot

“…48,49 Due to its significant hydrophobic properties, this polymer is highly suitable for the effective packing and retention of low-molecular-weight substances. 13,50 Our previous research has demonstrated that PLA microchamber arrays exhibit excellent resistance to mechanical deformation and better retention of FITCdextran and Solumedrol (methylprednisolone sodium succinate) in saline solution than other hydrophobic polymers such as PLGA and PCL. 20 2.4.…”

“…The PTMFs were made using PLA biopolymer because PLA has been approved by the US Food and Drug Administration (FDA) for human use and has also demonstrated potential for the production of patterned films. , Due to its significant hydrophobic properties, this polymer is highly suitable for the effective packing and retention of low-molecular-weight substances. , Our previous research has demonstrated that PLA microchamber arrays exhibit excellent resistance to mechanical deformation and better retention of FITC-dextran and Solumedrol (methylprednisolone sodium succinate) in saline solution than other hydrophobic polymers such as PLGA and PCL …”

Features of Anisotropic Drug Delivery Systems

“…Each method offers a distinct means of activating the release of dexamethasone from the capsules. [161] In another work, [170] the authors used layered polymers stained with dye to facilitate laser cutting over microsized squares. Due to the following heating step, the polymer layers melt forming semi-spherical articles.…”

“…In another work, [ 170 ] the authors used layered polymers stained with dye to facilitate laser cutting over microsized squares. Due to the following heating step, the polymer layers melt forming semi‐spherical articles.…”