Hydrogel Dressings for the Treatment of Burn Wounds: An Up-To-Date Overview

Stoica, Anca‐Iulia; Chircov, Cristina; Grumezescu, Alexandru Mihai

doi:10.3390/ma13122853

Cited by 115 publications

(91 citation statements)

References 174 publications

(243 reference statements)

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“…Additionally, hydrogels comprising this bioactive polymer could counteract the factors impairing healing processes by anti-inflammatory and antimicrobial actions [ 33 ]. Among all biomaterials, chitosan is one of the most frequently used ingredients in hydrogel preparation [ 34 , 35 ]; however, other formulations are also reported such as nanofibers [ 36 ] and nanoparticles [ 37 ]. Moreover, chitosan is often used as a coating material for vesicles [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control

et al. 2021

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Burns and other skin injuries are growing concerns as well as challenges in an era of antimicrobial resistance. Novel treatment options to improve the prevention and eradication of infectious skin biofilm-producing pathogens, while enhancing wound healing, are urgently needed for the timely treatment of infection-prone injuries. Treatment of acute skin injuries requires tailoring of formulation to assure both proper skin retention and the appropriate release of incorporated antimicrobials. The challenge remains to formulate antimicrobials with low water solubility, which often requires carriers as the primary vehicle, followed by a secondary skin-friendly vehicle. We focused on widely used chlorhexidine formulated in the chitosan-infused nanocarriers, chitosomes, incorporated into chitosan hydrogel for improved treatment of skin injuries. To prove our hypothesis, lipid nanocarriers and chitosan-comprising nanocarriers (≈250 nm) with membrane-active antimicrobial chlorhexidine were optimized and incorporated into chitosan hydrogel. The biological and antibacterial effects of both vesicles and a vesicles-in-hydrogel system were evaluated. The chitosomes-in-chitosan hydrogel formulation demonstrated promising physical properties and were proven safe. Additionally, the chitosan-based systems, both chitosomes and chitosan hydrogel, showed an improved antimicrobial effect against S. aureus and S. epidermidis compared to the formulations without chitosan. The novel formulation could serve as a foundation for infection prevention and bacterial eradication in acute wounds.

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Section: Resultsmentioning

confidence: 99%

Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control

et al. 2021

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“…Despite the large number of scientific reports based on wound dressing materials, including collagen, sodium carboxymethylcellulose or silver nanoparticles, there are limited studies on the usage of these particular 3 components altogether to obtain glutaraldehyde cross-linked and non-cross-linked porous composites with enhanced antimicrobial activity [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Collagen-Carboxymethylcellulose Biocomposite Wound-Dressings with Antimicrobial Activity

et al. 2021

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Microbial infections associated with skin diseases are frequently investigated since they impact on the progress of pathology and healing. The present work proposes the development of freeze-dried, glutaraldehyde cross-linked, and non-cross-linked biocomposite dressings with a porous structure, which may assist the reepithelization process through the presence of collagen and carboxymethylcellulose, along with a therapeutic antimicrobial effect, due to silver nanoparticles (AgNPs) addition. Phisyco-chemical characterization revealed the porous morphology of the obtained freeze-dried composites, the presence of high crystalline silver nanoparticles with truncated triangular and polyhedral morphologies, as well as the characteristic absorption bands of collagen, silver, and carboxymethylcellulose. In vitro tests also assessed the stability, functionality, and the degradability rate of the obtained wound-dressings. Antimicrobial assay performed on Gram-negative (Escherichia coli), Gram-positive (Staphyloccocus aureus) bacteria, and yeast (Candida albicans) models demonstrated that composite wound dressings based on collagen, carboxymethylcellulose, and AgNPs are suitable for skin lesions because they prevent the risk of infection and have prospective wound healing capacity. Moreover, the cell toxicity studies proved that the obtained materials can be used in long time treatments, with no cytotoxic effects.

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“…The hydrophilic nature of hydrogels is closely related to their impressive ability to absorb wound exudates and to maintain adequate wound bed moisture [ 397 , 398 ]. By also considering their intrinsic flexibility and swelling, similar hydration with skin tissue and circumstantial stimuli-responsive ability, (hydro)gel dressings help to substantially reduce pain scores, accelerate wound healing and prevent bacterial contamination by the facile incorporation of antimicrobial agents [ 358 , 399 ].…”

Section: Silver Nanoparticles For Wound Carementioning

confidence: 99%

An Updated Review on Silver Nanoparticles in Biomedicine

et al. 2020

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Silver nanoparticles (AgNPs) represent one of the most explored categories of nanomaterials for new and improved biomaterials and biotechnologies, with impressive use in the pharmaceutical and cosmetic industry, anti-infective therapy and wound care, food and the textile industry. Their extensive and versatile applicability relies on the genuine and easy-tunable properties of nanosilver, including remarkable physicochemical behavior, exceptional antimicrobial efficiency, anti-inflammatory action and antitumor activity. Besides commercially available and clinically safe AgNPs-based products, a substantial number of recent studies assessed the applicability of nanosilver as therapeutic agents in augmented and alternative strategies for cancer therapy, sensing and diagnosis platforms, restorative and regenerative biomaterials. Given the beneficial interactions of AgNPs with living structures and their nontoxic effects on healthy human cells, they represent an accurate candidate for various biomedical products. In the present review, the most important and recent applications of AgNPs in biomedical products and biomedicine are considered.

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Hydrogel Dressings for the Treatment of Burn Wounds: An Up-To-Date Overview

Cited by 115 publications

References 174 publications

Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control

Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control

Collagen-Carboxymethylcellulose Biocomposite Wound-Dressings with Antimicrobial Activity

An Updated Review on Silver Nanoparticles in Biomedicine

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