GDPD5, a target of miR-195-5p, is associated with metastasis and chemoresistance in colorectal cancer

Chen, Feng; Zhang, Lihong; Sun, Yonghai; Li, Xiaohong; Zhan, Lihui; Lou, Ye; Wang, Yandong; Liu, Lei; Zhang, Yanjie

doi:10.1016/j.biopha.2018.03.028

Cited by 48 publications

(40 citation statements)

References 44 publications

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“…MiRNAs regulate gene expressions by targeting 3′-UTR binding sites to inhibit mRNA translation and degradation, thus inhibit gene expression and further regulate the pathophysiological processes of various diseases. 28,29 By using TargetScan online software, MEIS2 was considered as a candidate target of miR-421. This result was later validated by luciferase reporter assay and qRT-PCR.…”

Section: Discussionmentioning

confidence: 99%

<p>ZFAS1 Promotes Cisplatin Resistance via Suppressing miR-421 Expression in Oral Squamous Cell Carcinoma</p>

Wang¹,

Hao²,

Wang³

et al. 2020

CMAR

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Oral squamous cell carcinoma (OSCC), with high incidence and mortality, represents one of the main reasons for head and neck malignant tumors. We want to investigate the effect of ZFAS1 on DDP resistance in oral squamous cell carcinoma. Methods: The proliferation and migration of cells was detected by CCK-8 and Transwell assay. The apoptosis was measured by flow cytometry and Western blot. The interaction of ZFAS1, miR-421, and MEIS2 was verified by luciferase reporter assay. The role of ZFAS1 in DDP resistance in vivo was tested by the nude mice model. The expression of ZFAS1 in exosomes from cisplatin-resistant patients was also determined. Results: ZFAS1 overexpression improved OSCC cell growth and inhibited OSCC cell susceptibility to DDP. In addition, the silencing of ZFAS1 promoted DDP-induced apoptosis. ZFAS1 directly bound to miR-421, which was verified by luciferase reporter assay. Inhibition of miR-421 reversed the effect of si-ZFAS1, which promoted the cell viability and decreased the sensitivity of DDP in DDP-resistant cells. The in vivo experiment showed the role of ZFAS1 in increasing the DDP resistance in OSCC tumor. Importantly, this study also showed upregulated ZFAS1 in serum exosomes derived from cisplatin-resistant patients. Conclusion: ZFAS1 promotes chemoresistance of oral squamous cell carcinoma to cisplatin and might become a latent therapeutic target for treating OSCC.

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Section: Discussionmentioning

confidence: 99%

<p>ZFAS1 Promotes Cisplatin Resistance via Suppressing miR-421 Expression in Oral Squamous Cell Carcinoma</p>

Wang¹,

Hao²,

Wang³

et al. 2020

CMAR

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“…Another fundamental drug is 5-FU. Literatures have been documented that the upregulation of miR-195-5p and miR-181a/135a/302c improves sensitivity to 5-FU in CRC cell lines and patients [105,106,142]. Interestingly, miR-195-5p can either overcome stemness and chemoresistance through suppressing the Notch2/RBPJ signaling [105] or dramatically increase chemosensitivity and apoptosis via inhibiting glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) [106].…”

Section: Lung Cancermentioning

confidence: 99%

“…Literatures have been documented that the upregulation of miR-195-5p and miR-181a/135a/302c improves sensitivity to 5-FU in CRC cell lines and patients [105,106,142]. Interestingly, miR-195-5p can either overcome stemness and chemoresistance through suppressing the Notch2/RBPJ signaling [105] or dramatically increase chemosensitivity and apoptosis via inhibiting glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) [106]. Besides, miR-148a has been proved to decrease the expression of some stem cell markers, induce apoptosis, inhibit cell invasion and migration, ultimately reduce chemoresistance in DDP-resistant CRC cell lines, partially by modulating WNT10b and β-catenin pathway [107].…”

Section: Lung Cancermentioning

confidence: 99%

Role of non-coding RNAs and RNA modifiers in cancer therapy resistance

et al. 2020

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As the standard treatments for cancer, chemotherapy and radiotherapy have been widely applied to clinical practice worldwide. However, the resistance to cancer therapies is a major challenge in clinics and scientific research, resulting in tumor recurrence and metastasis. The mechanisms of therapy resistance are complicated and result from multiple factors. Among them, non-coding RNAs (ncRNAs), along with their modifiers, have been investigated to play key roles in regulating tumor development and mediating therapy resistance within various cancers, such as hepatocellular carcinoma, breast cancer, lung cancer, gastric cancer, etc. In this review, we attempt to elucidate the mechanisms underlying ncRNA/modifier-modulated resistance to chemotherapy and radiotherapy, providing some therapeutic potential points for future cancer treatment.

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“…MiR-195-5p: MiR-195-5p is downregulated in CRC tissue and is associated with chemotherapy sensitivity in CRC by targeting glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) repression [196,197]. Downregulation of WNT3A by miR-195-5p inhibits CRC cell migration and proliferation [198].…”

Section: Pro-angiogenic Mirnas In Crcmentioning

confidence: 99%

Angioregulatory microRNAs in Colorectal Cancer

Soheilifar

Grusch

Neghab

et al. 2019

Cancers

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Colorectal cancer (CRC) is one of the leading causes of cancer mortality. Angiogenesis is a rate-determining step in CRC development and metastasis. The balance of angiogenic and antiangiogenic factors is crucial in this process. Angiogenesis-related genes can be regulated post-transcriptionally by microRNAs (miRNAs) and some miRNAs have been shown to shuttle between tumor cells and the tumor microenvironment (TME). MiRNAs have context-dependent actions and can promote or suppress angiogenesis dependent on the type of cancer. On the one hand, miRNAs downregulate anti-angiogenic targets and lead to angiogenesis induction. Tumor suppressor miRNAs, on the other hand, enhance anti-angiogenic response by targeting pro-angiogenic factors. Understanding the interaction between these miRNAs and their target mRNAs will help to unravel molecular mechanisms involved in CRC progression. The aim of this article is to review the current literature on angioregulatory miRNAs in CRC.

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GDPD5, a target of miR-195-5p, is associated with metastasis and chemoresistance in colorectal cancer

Cited by 48 publications

References 44 publications

<p>ZFAS1 Promotes Cisplatin Resistance via Suppressing miR-421 Expression in Oral Squamous Cell Carcinoma</p>

<p>ZFAS1 Promotes Cisplatin Resistance via Suppressing miR-421 Expression in Oral Squamous Cell Carcinoma</p>

Role of non-coding RNAs and RNA modifiers in cancer therapy resistance

Angioregulatory microRNAs in Colorectal Cancer

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