Role of non-coding RNAs and RNA modifiers in cancer therapy resistance

Zhang, Xinyi; Xie, Kai; Zhou, Huiping; Wu, Yuwei; Li, Chan; Liu, Yating; Liu, Zhaoya; Xu, Qian; Liu, Shuang; Xiao, Desheng; Tao, Yongguang

doi:10.1186/s12943-020-01171-z

Cited by 162 publications

(106 citation statements)

References 256 publications

(283 reference statements)

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“…In addition to miRNAs, ncRNAs contain several types including lncRNAs, circular RNA (circRNAs), small nuclear RNAs (snRNAs), and so on, making up 98% in the human genome [94]. Among these, lncRNA is the one first found as miRNA sponge [93], and many recent studies illustrated the role lncRNAs take in miRNA-related tumor regulation.…”

Section: Involved Mirna Sponges In Cancermentioning

confidence: 99%

miRNA-based biomarkers, therapies, and resistance in Cancer

et al. 2020

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MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in size, play important roles in gene regulation, and their dysregulation is implicated in human diseases including cancer. A variety of miRNAs could take roles in the cancer progression, participate in the process of tumor immune, and function with miRNA sponges. During the last two decades, the connection between miRNAs and various cancers has been widely researched. Based on evidence about miRNA, numerous potential cancer biomarkers for the diagnosis and prognosis have been put forward, providing a new perspective on cancer screening. Besides, there are several miRNA-based therapies among different cancers being conducted, advanced treatments such as the combination of synergistic strategies and the use of complementary miRNAs provide significant clinical benefits to cancer patients potentially. Furthermore, it is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis. With the belief that studies about miRNAs in human cancer would have great clinical implications, we attempt to summarize the current situation and potential development prospects in this review.

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Section: Involved Mirna Sponges In Cancermentioning

confidence: 99%

miRNA-based biomarkers, therapies, and resistance in Cancer

et al. 2020

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“…Recent studies have described the mechanisms of several ncRNAs in the regulation of the autophagy process in tumor cells (137). For instance, circNRIP1 was proven to modulate the autophagy and cancer cell metabolism switch into the Warburg effect by alteration of AKT1 expression and, consequently, the AKT/mTOR pathway, which induces tumor development and metastasis in gastric cancer (138).…”

Section: Autophagy and Non-coding Rnasmentioning

confidence: 99%

Autophagy Takes Center Stage as a Possible Cancer Hallmark

et al. 2020

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Cancer remains one of the leading causes of death worldwide, despite significant advances in cancer research and improvements in anticancer therapies. One of the major obstacles to curing cancer is the difficulty of achieving the complete annihilation of resistant cancer cells. The resistance of cancer cells may not only be due to intrinsic factors or factors acquired during the evolution of the tumor but may also be caused by chemotherapeutic treatment failure. Conversely, autophagy is a conserved cellular process in which intracellular components, such as damaged organelles, aggregated or misfolded proteins and macromolecules, are degraded or recycled to maintain cellular homeostasis. Importantly, autophagy is an essential mechanism that plays a key role in tumor initiation and progression. Depending on the cellular context and microenvironmental conditions, autophagy acts as a double-edged sword, playing a role in inducing apoptosis or promoting cell survival. In this review, we propose several scenarios in which autophagy could contribute to cell survival or cell death. Moreover, a special focus on novel promising targets and therapeutic strategies based on autophagic resistant cells is presented.

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“…Chemoresistance is one of the main causes for therapeutic failure in cancers. Dysregulated autophagy [ 8 , 107 , 108 ], lncRNAs [ 33 , 109 , 110 , 111 ], and circRNAs [ 107 , 112 , 113 , 114 , 115 ] have been indicated to be associated with drug resistance in cancers. ceRNAs can play important roles in the regulation of autophagy-mediated chemoresistance in cancers.…”

Section: Cerna-mediated Autophagy and Chemoresistancementioning

confidence: 99%

The Roles of ceRNAs-Mediated Autophagy in Cancer Chemoresistance and Metastasis

Zhang

Lü

2020

Cancers

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Chemoresistance and metastasis are the main causes of treatment failure and unfavorable outcome in cancers. There is a pressing need to reveal their mechanisms and to discover novel therapy targets. Autophagy is composed of a cascade of steps controlled by different autophagy-related genes (ATGs). Accumulating evidence suggests that dysregulated autophagy contributes to chemoresistance and metastasis via competing endogenous RNA (ceRNA) networks including lncRNAs and circRNAs. ceRNAs sequester the targeted miRNA expression to indirectly upregulate ATGs expression, and thereof participate in autophagy-mediated chemoresistance and metastasis. Here, we attempt to summarize the roles of ceRNAs in cancer chemoresistance and metastasis through autophagy regulation.

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Role of non-coding RNAs and RNA modifiers in cancer therapy resistance

Cited by 162 publications

References 256 publications

miRNA-based biomarkers, therapies, and resistance in Cancer

miRNA-based biomarkers, therapies, and resistance in Cancer

Autophagy Takes Center Stage as a Possible Cancer Hallmark

The Roles of ceRNAs-Mediated Autophagy in Cancer Chemoresistance and Metastasis

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