Angioregulatory microRNAs in Colorectal Cancer

Soheilifar, Mohammad Hasan; Grusch, Michael; Neghab, Hoda Keshmiri; Amini, Razieh; Maadi, Hamid; Saidijam, Massoud; Wang, Zhixiang

doi:10.3390/cancers12010071

Cited by 35 publications

(18 citation statements)

References 201 publications

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“…In recent decades, numerous evidence has revealed that miRNAs act as crucial players in the development of various types of human malignancies [ 38 , 39 ]. Accumulating researches have demonstrated that dysregulation of neoplasm-associated miRNAs is involved in the occurrence and development of human HCC [ 23 , 24 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-183-5p contributes to malignant progression through targeting PDCD4 in human hepatocellular carcinoma

Duan

et al. 2020

Bioscience Reports

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Hepatocellular carcinoma (HCC) remains one of the most common malignant tumors worldwide. This study aimed to investigate the biological role of microRNA-183-5p (miR-183-5p), a novel tumor-related miRNA, in HCC and illuminate the possible molecular mechanisms. The expression patterns of miR-183-5p in clinical samples were characterized using qPCR analysis. Kaplan-Meier survival curve was applied to evaluate the correlation between miR-183-5p expression and overall survival of HCC patients. Effects of miR-183-5p knockdown on HCC cell proliferation, apoptosis, migration and invasion capabilities were determined via CCK8 assays, flow cytometry, scratch wound healing assays and Transwell invasion assays, respectively. Mouse neoplasm transplantation models were established to assess the effects of miR-183-5p knockdown on tumor growth in vivo. Bioinformatics analysis, dual-luciferase reporter assays and rescue assays were performed for mechanistic researches. Results showed that miR-183-5p was highly expressed in tumorous tissues compared with adjacent normal tissues. Elevated miR-183-5p expression correlated with shorter overall survival of HCC patients. Moreover, miR-183-5p knockdown significantly suppressed proliferation, survival, migration and invasion of HCC cells compared with negative control treatment. Consistently, miR-183-5p knockdown restrained tumor growth in vivo. Furthermore, programmed cell death factor 4 (PDCD4) was identified as a direct target of miR-183-5p. Additionally, PDCD4 down-regulation was observed to abrogate the inhibitory effects of miR-183-5p knockdown on malignant phenotypes of HCC cells. Collectively, our data suggest that miR-183-5p may exert an oncogenic role in HCC through directly targeting PDCD4. The current study may offer some new insights for understanding the role of miR-183-5p in HCC.

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Section: Discussionmentioning

confidence: 99%

MicroRNA-183-5p contributes to malignant progression through targeting PDCD4 in human hepatocellular carcinoma

Duan

et al. 2020

Bioscience Reports

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“…The balance between angiogenic and anti-angiogenic factors is pivotal in the manipulation of angiogenesis. 48 Vascular endothelial growth factor A (VEGFA) and its receptors are two important factors in angiogenesis. 9 Recent researches on tumor metastasis highlighted the importance of miRNAs and angiogenesis.…”

Section: Main Textmentioning

confidence: 99%

Biological Implications and Clinical Potential of Metastasis-Related miRNA in Colorectal Cancer

Niu

Yang

Duan

et al. 2021

Molecular Therapy - Nucleic Acids

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Colorectal cancer (CRC), ranking as the third commonest cancer, leads to extremely high rates of mortality. Metastasis is the major cause of poor outcome in CRC. When metastasis occurs, 5-year survival rates of patients decrease sharply, and strategies to enhance a patient’s lifetime seem limited. MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that are significantly involved in manipulation of CRC malignant phenotypes, including proliferation, invasion, and metastasis. To date, accumulating studies have revealed the mechanisms and functions of certain miRNAs in CRC metastasis. However, there is no systematic discussion about the biological implications and clinical potential (diagnostic role, prognostic role, and targeted therapy potential) of metastasis-related miRNAs in CRC. This review mainly summarizes the recent advances of miRNA-mediated metastasis in CRC. We also discuss the clinical values of metastasis-related miRNAs as potential biomarkers or therapeutic targets in CRC. Moreover, we envisage the future orientation and challenges in translating these findings into clinical applications.

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“…MicroRNA (miRNA) are small non-coding RNA (18-25 bases) molecules that regulate gene expression at the posttranscriptional level through degradation or translational repression of a target mRNA. It has been reported that Nivolumab Checkpoint inhibitors Second line [102] deregulation of miRNAs can lead to abnormal angiogenesis, which is the hallmark of cancer [85] Table 3 summarizes the main microRNAs associated with angiogenesis in endothelial cell, pericytes, and CSC.…”

Section: Mechanism Of Regulation Of Pericytes and Cscmentioning

confidence: 99%