Pericytes Relationship with Cancer Stem Cells in the Colon

Garza-Treviño, Elsa N.; Delgado-González, Paulina; Salgado, Carlos I. Valencia; García, Jesús

doi:10.1007/s43152-020-00015-8

Cited by 2 publications

(1 citation statement)

References 101 publications

(74 reference statements)

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“…-Predicts survival in liver metastasis during treatment. [101] Recently aneuploidy, leading to genomic instability is known to be the most common characteristic of malignant cells, was detected on CD31+ CTECs, together with their counterpart CD31-circulating tumor cells (CTCs), together they constitute a unique pair of cellular circulating tumor biomarkers [13,102,103]. In addition, the basic helix loop helix factor Twist1 seem to be activated by hypoxia, by this effect it can induce differentiation of tumor cells into endothelial cells and promote tumor-derived vascular formation [104].…”

Section: Asphmentioning

confidence: 99%

Therapeutic Approaches for Metastases from Colorectal Cancer and Pancreatic Ductal Carcinoma

et al. 2021

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Metastasis is the process of dissemination of a tumor, whereby cells from the primary site dislodge and find their way to other tissues where secondary tumors establish. Metastasis is the primary cause of death related to cancer. This process warrants changes in original tumoral cells and their microenvironment to establish a metastatic niche. Traditionally, cancer therapy has focused on metastasis prevention by systematic treatments or direct surgical re-sectioning. However, metastasis can still occur. More recently, new therapies direct their attention to targeting cancer stem cells. As they propose, these cells could be the orchestrators of the metastatic niche. In this review, we describe conventional and novel developments in cancer therapeutics for liver and lung metastasis. We further discuss the resistance mechanisms of targeted therapy, the advantages, and disadvantages of diverse treatment approaches, and future novel strategies to enhance cancer prognosis.

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