GC–MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts

Chirumamilla, Pavani; Dharavath, Sunitha Bai; Taduri, Shasthree

doi:10.1186/s42269-022-00818-9

Cited by 20 publications

(8 citation statements)

References 28 publications

(26 reference statements)

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“…However least antimicrobial activity was shown for B. Subtilis and E. Coli (Graph III). Similar findings were reported in Carica papaya, Eurycoma longifolia, Amaranthus spinosus and Solanum khasianum [20][21][22][23][24][25] .…”

Section: Antibacterial Activitysupporting

confidence: 85%

Preliminary phytochemical screening and antibacterial activity of tinospora cordifolia

Ahmadi,

Askani,

Fathima

et al. 2023

J. Med. Plants Stud.

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The present study of preliminary phytochemical screening and antibacterial activity was carried out in Tinospora cordifolia leaf, stem and roots extracts. Standard procedure involving cold maceration technique was conducted on the plant extracts for screening the phytochemical constituents using different polar solvents like aqueous, methanol, butanol and ethanol and a non-polar solvent like chloroform. This was followed by antibacterial activity using plant butanolic extracts by using well diffusion method since the butanolic extract of leaf, stem and root of T. cordifolia showed highest positive results for the presence of phytochemicals. Further in antibacterial activity highest zone of inhibition was shown at 80 µg/ml concentration against Escherechia coli in stem butanolic extract. Hence it became evident that T. cordifolia comprises of copious phytochemicals/secondary metabolites which possess antibacterial properties and can be used for development of novel drugs for curing infectious diseases.

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Section: Antibacterial Activitysupporting

confidence: 85%

Preliminary phytochemical screening and antibacterial activity of tinospora cordifolia

Ahmadi,

Askani,

Fathima

et al. 2023

J. Med. Plants Stud.

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“…nigrum and M. arvensis confirmed that they contained all the potent phytochemicals and bioactive compounds responsible for nematicidal activities. ,− The detailed information is listed in Table (phytochemicals) and Table (chemical compounds). The leaf extracts of S.…”

Section: Resultsmentioning

confidence: 87%

Nematicidal Characterization of Solanum nigrum and Mentha arvensis Leaf Extracts Using Caenorhabditis elegans as a Model Organism

et al. 2023

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Considering foremost global issues instigated by parasitic nematodes, Solanum nigrum (S. nigrum) and Mentha arvensis (M. arvensis) nematicidal potential at the gene level has been explored herein. Methanol, ethyl acetate, chloroform, n-hexane, and distilled water were used for extract preparation. Caenorhabditis elegans (C. elegans) was used as the model organism. Nematicidal and anti-egg hatching assays, fluorescence microscopy, and quantitative real-time PCR were done. S. nigrum chloroform (LD 50 = 1.21 mg/mL) and M. arvensis methanol (LD 50 = 2.47 mg/mL) extracts exhibited excellent nematicidal potential. Both plants showed potent anti-egg hatching activity (1 mg/mL). S. nigrum methanol and M. arvensis ethyl acetate extracts showed high apoptotic effect in muscles, gonads, and uterus (eggs). Stress genes, that is, gst-4, hsp-16.2, and gpdh-1 were highly expressed in affected C. elegans (treated with S. nigrum and M. arvensis leaf extracts) when compared with normal C. elegans. Phytochemicals and bioactive compounds present in plants may be the major cause of their excellent nematicidal potential, which further confirmed that both plants could be an alternative candidate(s) for novel broad-scale anthelmintic drug(s).

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“…Studies on phytochemicals are developing and accurately certified on a regular basis. For bioprospecting for plant bioactive chemicals, GCMS has been demonstrated to be a useful instrument [29]. The identified phytoconstituents in stem methanolic extract, which is responsible for their widespread usage in medical help, include ethyl iso-allocholate reported to possess antimicrobial, diuretic, anti-inflammatory, and antiasthma activities [30].…”

Section: Discussionmentioning

confidence: 99%

Chemical profiling, in vitro antibacterial, and cytotoxic properties of Elytranthe parasitica (L.) Danser – A hemiparasitic Indian mistletoe

Sharath¹,

Naika²

2022

J App Biol Biotech

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Elytranthe parasitica, popularly known as Macrosolen parasiticus, is a hemiparasitic mistletoe species in India. It has been traditionally used in veterinary medicine. The main objective of this research is to examine its chemical constituents, and in vitro antibacterial, and cytotoxic activities. The qualitative screening of phytoconstituents revealed the existence of tannins, phenols, glycosides, flavonols, sterols, saponins, terpenoids, carbohydrates, fixed oil, and fats. Gas Chromatography-Mass Spectroscopy screening of stem methanol extract showed the appearance of 11 bioactive phytoconstituents. Octadecenoic acid,4-hydroxybutyl ester (22.95%); 2H-1-Benzopyran-7-ol, 3,4-dihydro-5-methoxy-2-phenyl-(21.90%); Oleic acid (14.18%); and 9-Hexadecenoic acid (10.59%) were the major identified compounds. The methanolic stem extract exhibited considerable antibacterial activity and showed a good inhibition zone against Xanthomonas campestris (19.83 ± 44 mm) followed by Salmonella typhi (15.50 ± 0.28 mm) and Enterococcus faecalis (15.50 ± 0.28 mm) and the minimum inhibition zone showed against Escherichia coli (12.66 ± 0.33 mm). The methanolic stem extract showed, moderate cytotoxicity on prostate, and pancreatic cancer cell lines at higher concentrations with the inhibitory concentration at 50% growth values 372.27 ± 22.07 µg/mL and 443.33 ± 17.85 µg/mL, respectively, but it has no cytotoxic effects on normal mouse embryo fibroblast cells (MEF-L239).

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GC–MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts

Cited by 20 publications

References 28 publications

Preliminary phytochemical screening and antibacterial activity of tinospora cordifolia

Preliminary phytochemical screening and antibacterial activity of tinospora cordifolia

Nematicidal Characterization of Solanum nigrum and Mentha arvensis Leaf Extracts Using Caenorhabditis elegans as a Model Organism

Chemical profiling, in vitro antibacterial, and cytotoxic properties of Elytranthe parasitica (L.) Danser – A hemiparasitic Indian mistletoe

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