GC-MS analysis of bio-active compounds in methanolic extract of Lactuca runcinata DC

Kanthal, Lakshmi Kanta; Dey, Akalanka; Satyavathi, K.; Bhojaraju, P.

doi:10.4103/0974-8490.122919

Cited by 89 publications

(48 citation statements)

References 11 publications

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“…Berries were grinded and extracted three times with ethanol 70%. The extracts were filtered through filter paper and each filtrate was concentrated under vacuum using Rotary evaporator (Heidolph-Germany) till dryness [38,39]. The crude extracts were obtained and stored at 4 °C for further investigations.…”

Section: Red and White Berry Fruit Ethanolic Extracts Preparationmentioning

confidence: 99%

Berry Extracts Improved Inflammatory Cytokines, Antioxidant Enzyme and Suppressed the Gene Expression Alterations in Diabetic Rats

Baz

Khalil

Aly

et al. 2016

Int J Pharm Pharm Sci

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Objective: The present work was conducted to evaluate the ameliorative effect of red berry (Morus rubra) and white berry (Morus alba) extracts in diabetic rats.Methods: Inflammatory biomarkers; tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), transforming growth factor-β (TGF-β), paraoxanase1 (PON1), gene expression of apoptosis and inflammatory related genes were carried out.Results: Treatment of male rats with streptozotocin (STZ) to induce diabetes increased the levels of TNF-α, IL-1β, TGF-β, the apoptosis rates and the alterations of the pro-apoptosis (eotaxin, caspase-1, and caspase-2) and inflammation; nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB1) and allograft inflammatory factor 1 (AIF-1) related genes. While marked reduction in PON1 level was detected in STZ-induced diabetic rats. However, treatment of STZ-exposed rats with red and white berry extracts exhibited noticeable ameliorations in TNF-α, IL-1β, TGF-β levels and PON1 activity as well as low apoptosis rates and decreased the alteration of the pro-apoptosis and inflammatory related genes. Conclusion:Red and white berry extracts exhibited attenuation in antioxidant status, suppressed inflammatory cytokines, apoptosis and the alterations in the apoptosis and inflammatory related genes induced by STZ in male rats.

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Section: Red and White Berry Fruit Ethanolic Extracts Preparationmentioning

confidence: 99%

Berry Extracts Improved Inflammatory Cytokines, Antioxidant Enzyme and Suppressed the Gene Expression Alterations in Diabetic Rats

Baz

Khalil

Aly

et al. 2016

Int J Pharm Pharm Sci

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“…were found to be more effective against Salmonella species [41]. Also, methanolic extract of gyrocarpus asiaticus willd showed an effect in reducing the salmonella species [42]. A combination of plant extracts which includes Allium sativum (Amaryllidaceae), Szygium aromaticum (Myrtaceae), Berberis aristata (berberidace), Rhus cotinus (Anacardiaceae) and phyllanthus emblica (Phyllanthaceae) also showed a positive effect in restricting Salmonella species [43].…”

Section: Prospective Treatment Optionsmentioning

confidence: 99%

Enteric Fever in Travelers: An Updated Insight

Team

2016

Asian J Pharm Clin Res

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Enteric fever is a broad term used to represent typhoid and paratyphoid fever which is caused by S. typhi and S. paratyphi respectively. The most common cause being S. typhi, overall. However, S. paratyphi is known to infect the travelers at a higher rate. Indian subcontinent being one of the most endemic region, it is always beneficial for the travelers to get immunized while traveling to these areas. However, Vaccination to S. paratyphi is not yet available, hence travelers often fall prey to the disease. The morbidity is often high but mortality is very rare, especially due to first line treatment drugs like ceftriaxone, nalidixic acid and floroquinolones (if patients are sensitive to it). Recently, it was observed that Multi-drug resistance (Resistance to at least ampicillin, chloramphenicol and trimethoprim-sulfamethoxazole]) was limited to Typhi isolates and was increased at an exponential rate. Hence, with increasing resistance to these drugs, developing vaccines or new drugs against these bacteria, remains an area of prime interest.

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“…Gas Chromatography-Mass Spectrometry (GC-MS), among other hyphenated techniques described elsewhere [7][8][9], offers a reliable and reproducible analytical protocol for the identification, quantitation and characterization of bioactive principles from herbal extracts [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

GC–MS Analysis of Aqueous Extract of Unripe Fruit of Carica papaya

Ezekwe¹,

Chikezie²

2017

J Nutr Food Sci

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The present study was aimed to identify the likely phytocomponents present in Aqueous Extract of Unripe Fruit (AqEUF) of Carica papaya. The phytocomponents present in AqEUF of C. papaya was identified using GC-MS detection system. The results showed the presence of fifteen phytocomponents in AqEUF of C. papaya. The major phytocomponents present in AqEUF of C. papaya in terms of their relative abundance were octadecanoic acid, hexadecenoic acid, Z-11 and hexadecanoic acid, methyl ester, which corresponded to 23.84%, 19.17% and 18.25% respectively. The relative abundance of minor phytocomponents present in AqEUF of C. papaya was within a narrow range of 0.78-5.38%. The present investigation revealed that AqEUF of C. papaya was composed of variety of metabolites and therapeutic active substances as well as novel substances. These substances could be isolated and further empirically evaluated to confirm their biologic and medicinal activities as well as investigate their mechanism of action.

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GC-MS analysis of bio-active compounds in methanolic extract of Lactuca runcinata DC

Cited by 89 publications

References 11 publications

Berry Extracts Improved Inflammatory Cytokines, Antioxidant Enzyme and Suppressed the Gene Expression Alterations in Diabetic Rats

Berry Extracts Improved Inflammatory Cytokines, Antioxidant Enzyme and Suppressed the Gene Expression Alterations in Diabetic Rats

Enteric Fever in Travelers: An Updated Insight

GC–MS Analysis of Aqueous Extract of Unripe Fruit of Carica papaya

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