Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: Involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin E2

Rozza, Ariane Leite; Moraes, Thiago de Mello; Kushima, Hélio; Tanimoto, Alexandre; Marques, Márcia Ortiz Mayo; Bauab, Taís Maria; Hiruma-Lima, Clélia Akiko; Pellizzon, Cláudia Helena

doi:10.1016/j.cbi.2010.09.031

Cited by 116 publications

(89 citation statements)

References 46 publications

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“…One of the main mechanisms attributed to the toxic effect of ethanol is the alteration in gastric cell homeostasis and tissue damage resulting from its direct action on the mucosa and the formation of free radicals and reactive oxygen species (19,20) .…”

Section: Discussionmentioning

confidence: 99%

Screening of Wild Fruit Trees With Gastroprotective Activity in Different Experimental Models

Nesello

Campos

Rosa

et al. 2017

Arq. Gastroenterol.

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-Background -Given the increase of people with gastrointestinal disorders, the search for alternative treatments with fewer side effects is vital, as well as the demand for food or plants that can help protect the stomach. Objective -The aim of this study was to evaluate the gastroprotective action of the extracts of wild fruit trees of Myrcianthes pungens (guabiju); Inga vera Willd. (ingá-banana) and Marlierea tomentosa Cambess. (guarapuruna) in in vivo pharmacological models. Methods -The different parts of the fruits were separately subjected to a process of extraction by methanol. Two experimental pharmacological models were conducted in mice; the gastric ulcer model induced by non-steroidal anti-inflammatory (indomethacin), and the gastric ulcer model induced by ethanol/HCl, which allowed us to evaluate the gastroprotective activity of the extracts at a dose of 250 mg/kg. Subsequently, the total lesion area (mm 2 ) and relative lesion area (%) were determined. Results -The results showed significant gastroprotective activity against the aggressive agents used -ethanol and indomethacin -for all the extracts tested. Conclusion -It is assumed that the fruits have bioactive compounds such as antioxidant substances that act on the prostaglandin levels, protecting them from the damage caused by ethanol and indomethacin. These results prompt further studies to isolate and identify the active properties.

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Section: Discussionmentioning

confidence: 99%

Screening of Wild Fruit Trees With Gastroprotective Activity in Different Experimental Models

Nesello

Campos

Rosa

et al. 2017

Arq. Gastroenterol.

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“…They stimulate the patients' appetite and empower their stomachs through special features like varnishing (Jali), fragmenting, or heating (9,15). Major compounds in lemon (phenolic compounds and essential oils) have demonstrated gastroprotective property including elevated mucus secretion and anti-ulcer activity (22). Antibacterial, anti-H. pylori, antiinflammatory, and antioxidant effects of black mustard have been explained in current essays with different methods (23)(24)(25).…”

Section: Resultsmentioning

confidence: 99%

Preventive Care for Gastrointestinal Disorders; Role of Herbal Medicines in Traditional Persian Medicine

Jahromi

Pasalar

Afsharypuor

et al. 2015

Jundishapur J Nat Pharm Prod

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Context: Preventive care is a basic rule in current medical practice and traditional Persian medicine (TPM) scholars have introduced a large amount of publications in this valued field. According to TPM principles, healthy stomach has a significant role in providing a fit body and herbal medicines are capable of helping stomach perform this role. Evidence Acquisition: A wide-ranging search in main TPM books and web engines was performed to compare preventive care in gastrointestinal (GI) diseases through a librarian review study. Results: There is a close interaction between GI system and other body systems; any ailment in a system could result in dysfunction of stomach and vice versa. There are various herbal medicines that help achieving a healthy stomach following a seven-part preventive rule and in this article, we briefly reviewed some of them such as amla, clove, lemon, black mustard, saffron, ginger, aloe, and mastic. Conclusions: Following a simple seven-part rule of healthy stomach will result in balanced GI function and a healthy body. Properly consumption of recommended TPM herbal medicines could reinforce the stomach and a healthy GI system through preventive mechanisms.

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“…Likewise, aqueous extract of Solanum nigrum at a dose of 4g/kg exhibited no preventive effect in an animal model of aspirin-induced gastric ulcer while the same dose of methanolic extract induced an over 20% inhibition of ulcer index (Akhtar and Munir., 1989). Similarly, methanolic extract of Luffa acutangula is more effective than its aqueous extract (Rozza et al, 2011). In contrast, aqueous extract of Brassica oleracea, but not methanolic extract, induced a 42% inhibition of ulcer index (Akhtar and Munir., 1989).…”

Section: Efficacymentioning

confidence: 98%

Anti-Ulcerogenic Efficacy and Mechanisms of Edible and Natural Ingredients in Nsaid-Induced Animal Models

Man

2017

Afr J Tradit Complement Altern Med

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Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of the most commonly used medicines and proven to be effective for certain disorders. Some people use NSAIDs on daily basis for preventive purpose. But a variety of severe side effects can be induced by NSAIDs. Studies have shown that edible natural ingredients exhibit preventive benefit of gastric ulcer. This paper reviews the efficacy and safety of edible natural ingredients in preventing the development of gastric ulcer induced by NSAIDs in animal models. Methods: A systematic literature search was conducted on PubMed, using the terms "herbal medicines" and "gastric ulcer", "herbal medicines" and "peptic ulcer", "food" and "peptic ulcer", "food" and "gastric ulcer", "natural ingredient" and "peptic ulcer", "natural ingredient" and "gastric ulcer", "alternative medicine" and "peptic ulcer", "alternative medicine" and "gastric ulcer", "complementary medicine" and "peptic ulcer", "complementary medicine" and "gastric ulcer" in papers published in English between January 1, 1960 and January 31, 2016, resulting in a total of 6146 articles containing these terms. After exclusion of studies not related prevention, not in NSAID model or using non-edible natural ingredients, 54 articles were included in this review.Results: Numerous studies have demonstrated that edible natural ingredients exhibit antiulcerogenic benefit in NSAIDinduced animal models. The mechanisms by which edible, ingredient-induced anti-ulcerogenic effects include stimulation of mucous cell proliferation, antioxidation, inhibition of gastric acid secretion, as well as inhibition of H(+), K(+)-ATPase activities. Utilization of edible, natural ingredients could be a safe, valuable alternative to prevent the development of NSAID-induced gastric ulcer, particularly for the subjects who are long-term users of NSAIDs.

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Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: Involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin E2

Cited by 116 publications

References 46 publications

Screening of Wild Fruit Trees With Gastroprotective Activity in Different Experimental Models

Screening of Wild Fruit Trees With Gastroprotective Activity in Different Experimental Models

Preventive Care for Gastrointestinal Disorders; Role of Herbal Medicines in Traditional Persian Medicine

Anti-Ulcerogenic Efficacy and Mechanisms of Edible and Natural Ingredients in Nsaid-Induced Animal Models

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