Screening of Wild Fruit Trees With Gastroprotective Activity in Different Experimental Models

Abstract

-Background -Given the increase of people with gastrointestinal disorders, the search for alternative treatments with fewer side effects is vital, as well as the demand for food or plants that can help protect the stomach. Objective -The aim of this study was to evaluate the gastroprotective action of the extracts of wild fruit trees of Myrcianthes pungens (guabiju); Inga vera Willd. (ingá-banana) and Marlierea tomentosa Cambess. (guarapuruna) in in vivo pharmacological models. Methods -The different parts of the fruits were separately subjected to a process of extraction by methanol. Two experimental pharmacological models were conducted in mice; the gastric ulcer model induced by non-steroidal anti-inflammatory (indomethacin), and the gastric ulcer model induced by ethanol/HCl, which allowed us to evaluate the gastroprotective activity of the extracts at a dose of 250 mg/kg. Subsequently, the total lesion area (mm 2 ) and relative lesion area (%) were determined. Results -The results showed significant gastroprotective activity against the aggressive agents used -ethanol and indomethacin -for all the extracts tested. Conclusion -It is assumed that the fruits have bioactive compounds such as antioxidant substances that act on the prostaglandin levels, protecting them from the damage caused by ethanol and indomethacin. These results prompt further studies to isolate and identify the active properties.

Phytochemical Profile and Gastroprotective Activity of Eugenia Mattosii Fruits

“…A recent study with M. pungens (leaves and seeds) and M. tomentosa (peel and seeds) (Myrtaceae family) extracts, using the same models of the present study, verified that all treatments, at the dose of 250 mg/kg, exhibited gastroprotective activity when compared to the negative control group (distilled water) (13) . RESUMO -Contexto -Extratos obtidos de plantas e frutos fornecem uma alternativa relativamente segura e prática para os remédios convencionais de doenças gastrointestinais.…”

“…Luana dos SANTOS 1 , Adriana CAMPOS 2 , Valdir CECHINEL FILHO 2 and Luciane Angela Nottar NESELLO 2 dysenterica (11) , Eugenia umbelliflora (12) , Myrcianthes pungens and Marlierea tomentosa (13) .…”

Activity of Orbignya Phalerata and Euterpe Edules in the Prevention and Treatment of Peptic Ulcer in Rats

“…In this study, all animals in the alcohol group developed ulcer after gavage, with a macroscopic perception of petechiae. As observed by Nesselo et al 12 in 2017, animals with gastric lesions induced by ethanol presented areas of necrosis and/or hemorrhage in the gastric mucosa, proving the toxicity of this agent. Mizui and Doteuchi 10 defined in 1983 that the ethanol induction model evaluates, among others, the activity of cytoprotective substances.…”

“…al. 12 , one of the major mechanisms attributed to the toxic effect of ethanol is the change in gastric cell homeostasis and tissue damage resulting from a direct action on mucosa and the formation of free radicals and reactive oxygen species.As described in 2009 in a paper published by Shine et al 17 , the authors inferred that the ethanol metabolized by the organism causes an increase in the production of O 2 in the tissues and, simultaneously, an increase of cellular free radical concentration. These free radicals could cause DNA strand breaks and protein denaturation, resulting in gastric lesion.…”