Gastroprotective effect of Nigella sativa seed on ethanol-induced gastric ulcer in rats

Bukar, M; Ishaya, Helga Bedan; Dibal, Nathan Isaac; Attah, Martha Orendu Oche

doi:10.4103/ljms.ljms_23_17

Cited by 8 publications

(4 citation statements)

References 1 publication

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“…This dual action highlights the herb's potential in protecting the stomach lining and preventing ulcerative conditions, presenting a valuable therapeutic avenue for gastrointestinal health. 33,34 11.4. Hepatoprotective N. sativa exhibits hepatoprotective effects by mitigating oxidative stress in the liver and facilitating the restoration of normal liver function.…”

Section: Gastroprotectivementioning

confidence: 99%

Current trends in Nigella sativa L. (Black seed) from traditional to modern medicine with advances in extraction, formulation, quality control, regulatory status, and pharmacology

Almoselhy,

Usmani

2024

IJPCA

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For the first time ever, this novel review enters the enigmatic world of the L. (black seed), known for centuries as a potent source of healing including their relevance to the food and pharmaceutical industries. Written at professional and reference level, it is directed at normal readers with more professional scientists in pharmacy and food science affiliations to serve as a rich source of data on black seed. We embark on an exploration that encompasses the background, significance, and objectives guiding our exploration. Detailed botanical and chemical profiles unravel the mysteries of the black seed, providing insight into its taxonomy, morphology, and chemical composition. Traditional uses, extraction methods, and formulation approaches paint a comprehensive picture of the versatile ways in which the black seed has been employed throughout history. Quality control and standardization practices ensure the integrity of black seed-derived products, while a global regulatory overview brings into focus the challenges and triumphs of incorporating this botanical powerhouse into mainstream pharmacopeias. As we delve into the pharmacological activities, clinical studies, and efficacy of the black seed, we confront safety considerations and potential side effects. The exploration extends into the future, addressing the challenges in commercialization, identifying research gaps, and concluding with the implications of our findings for both healthcare and industry. It should therefore be of special value to researchers affiliated with food science and technology, pharmacy, and pharmaceutical producers requiring up-to-date information on their raw materials, which will probably already have been processed, at least in part.

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Section: Gastroprotectivementioning

confidence: 99%

Current trends in Nigella sativa L. (Black seed) from traditional to modern medicine with advances in extraction, formulation, quality control, regulatory status, and pharmacology

Almoselhy,

Usmani

2024

IJPCA

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“…[20][21][22][23] cardiovascular system disorders, 24 gastrointestinal diseases. 25,26 liver diseases. 27 asthma.…”

Section: Pharmacological Properties Of N Sativamentioning

confidence: 99%

Novel positioning of L. (Black seed) from farm to pharma indexed in pharmacopeia

I.M. Almoselhy,

Usmani

2024

JPBS

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The current study examines the regulatory status and inclusion of in pharmacopeias across diverse regions. The regulatory landscape varies globally, with some countries recognizing it as a traditional medicine in pharmacopeias, while others impose restrictions due to safety and efficacy concerns. The lack of standardized guidelines complicates its status, ranging from dietary supplement to traditional herbal medicine in different regions. A pivotal shift is observed in the Egyptian Herbal Monograph Volume 3, marking Black Seed's evolution from traditional medicinal use to a recognized pharmaceutical preparation in the pharmacopeia. This transition signifies a move towards evidence-based medicine, emphasizing rigorous scientific scrutiny and standardization. The integration of Black Seed underscores growing recognition of its efficacy and safety, transforming it into a pharmaceutical product and consolidating its position in mainstream healthcare. The inclusion not only enhances patient accessibility but also instills confidence among healthcare practitioners, solidifying Black Seed as a trusted therapeutic agent. The debate around N. sativa's inclusion continues, with traditional medicine systems endorsing its value, while modern pharmacopeias grapple with standardization and quality control. N. sativa emerges as a promising natural resource, necessitating comprehensive documentation for its prospective inclusion in evidence-based healthcare practices and official guidelines.

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“…A 93.8% digestibility coefficient was recorded for it 3 . In terms of pharmacological effects, it was analgesic 4 , hypotensive 5 , antiviral 6 , wound healing 7 and anti-inflammatory. Avocado pulp oil's bioactive component composition is regulated by the extraction and drying techniques 8 .…”

Section: Introductionmentioning

confidence: 99%

GC-MS and Antioxidative Effects of Poly Herbal Formulation of Persea americana Seed Against Ethanol-Induced Gastric Ulcer in Rats

Umaru,

Ejeh,

Umaru

et al. 2023

Asian J. Biol. Sci

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Background and Objective: Plant-derived natural products have considerable significant attention due to their various pharmacological properties and functions. Avocado (Persea americana Mill.), is a fruit that is native to Central America. GC-MS analyses of avocado samples showed α-tocopherol, squalene, cycloartenol acetate, β-sitosterol, campesterol and stigmasterol. This study aims to check the gastroprotective and antioxidant effect of avocado seed extract on gastric ulcer. Materials and Methods: A total of 60 experimental rats were used and divided into a group of six in two experimental designs and administered treatments with the crude extract of virgin avocado. Results: Results were expressed as Mean±Standard Error of the Mean (SEM). Statistical significance was determined using a One-way Analysis of Variance (ANOVA) followed by Tukey's post hoc Test. Values of p<0.05 were considered to be significant. The result of the GC-MS profile of the ethanol crude extract of avocado seed extract was found to compose of 30 chemical constituents which can be used to manage different kinds of ailments. Conclusion: Avocado seed extract has potential antioxidant activity in vitro and in vivo. Oral administration of Avocado seed extract once daily for 7 days alleviates gastric ulcers induced by ethanol, but more significant was observed with the formulation.

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Gastroprotective effect of Nigella sativa seed on ethanol-induced gastric ulcer in rats

Cited by 8 publications

References 1 publication

Current trends in Nigella sativa L. (Black seed) from traditional to modern medicine with advances in extraction, formulation, quality control, regulatory status, and pharmacology

Current trends in Nigella sativa L. (Black seed) from traditional to modern medicine with advances in extraction, formulation, quality control, regulatory status, and pharmacology

Novel positioning of L. (Black seed) from farm to pharma indexed in pharmacopeia

GC-MS and Antioxidative Effects of Poly Herbal Formulation of Persea americana Seed Against Ethanol-Induced Gastric Ulcer in Rats

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