Gastroprotective effect of barbatusin and 3-beta-hydroxy-3-deoxibarbatusin, quinonoid diterpenes isolated from Plectranthus grandis, in ethanol-induced gastric lesions in mice

Rodrigues, Patrícia; Morais, Selene Maia de; Souza, Carolina Augusto de; Silva, Ana Raquel Araújo; Andrade, Geanne Matos de; Silva, Maria Goretti Vasconcelos; Albuquerque, Roberto Lima de; Rao, V. S. N.; Santos, Flávia Almeida

doi:10.1016/j.jep.2009.11.031

Cited by 27 publications

(10 citation statements)

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“…It's well know that peptic ulcer disease arises from the imbalance between the mucosal protective factors and the aggressive factors [ 30 ] and many gastroprotective agents were found to improve the cellular integrated work to increase mucosal resistance or to decrease the aggressive factors [ 31 ]. Nowadays, the therapeutic strategy for peptic ulcer treatment is focused on either the suppression of gastric acid secretion or the enhancement of gastro-protective factors [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Antisecretory, Gastroprotective, Antioxidant and Anti-Helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) Smith

et al. 2015

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Background Zingiber zerumbet Smith is a perennial herb, broadly distributed in many tropical areas. In Malaysia, it’s locally known among the Malay people as “lempoyang” and its rhizomes, particularly, is widely used in traditional medicine for the treatment of peptic ulcer disease beyond other gastric disorders.Aim of the studyThe aim of the current study is to evaluate the gastroprotective effect of zerumbone, the main bioactive compound of Zingiber zerumbet rhizome, against ethanol-induced gastric ulcer model in rats.Materials and MethodsRats were pre-treated with zerumbone and subsequently exposed to acute gastric ulcer induced by absolute ethanol administration. Following treatment, gastric juice acidity, ulcer index, mucus content, histological analysis (HE and PAS), immunohistochemical localization for HSP-70, prostaglandin E2 synthesis (PGE2), non-protein sulfhydryl gastric content (NP-SH), reduced glutathione level (GSH), and malondialdehyde level (MDA) were evaluated in ethanol-induced ulcer in vivo. Ferric reducing antioxidant power assay (FRAP) and anti-H. pylori activity were investigated in vitro.ResultsThe results showed that the intragastric administration of zerumbone protected the gastric mucosa from the aggressive effect of ethanol-induced gastric ulcer, coincided with reduced submucosal edema and leukocyte infiltration. This observed gastroprotective effect of zerumbone was accompanied with a significant (p <0.05) effect of the compound to restore the lowered NP-SH and GSH levels, and to reduce the elevated MDA level into the gastric homogenate. Moreover, the compound induced HSP-70 up-regulation into the gastric tissue. Furthermore, zerumbone significantly (p <0.05) enhanced mucus production, showed intense PAS stain and maintained PG content near to the normal level. The compound exhibited antisecretory activity and an interesting minimum inhibitory concentration (MIC) against H. pylori strain.ConclusionThe results of the present study revealed that zerumbone promotes ulcer protection, which might be attributed to the maintenance of mucus integrity, antioxidant activity, and HSP-70 induction. Zerumbone also exhibited antibacterial action against H. pylori.

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Section: Discussionmentioning

confidence: 99%

Antisecretory, Gastroprotective, Antioxidant and Anti-Helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) Smith

et al. 2015

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“…Samples of the gastric mucosa were fixed in formaldehyde (10%, v/v) and prepared in 0.01 M PBS, pH 7.2, over 24 h for histopathology procedures. Sections (5 μ m) were stained with hematoxylin-eosin to evaluate gastric mucosal injury according to the criteria of Laine and Weinstein [ 22 ], as follows: edema in the upper mucosa (0–4), hemorrhagic damage (0–4), epithelial cell loss (0–3), and the presence of inflammatory cells (0–3). Photomicrographs of sections were obtained with a Leica DM microscope equipped with a Leica DFC 280 camera (200x magnification).…”

Section: Methodsmentioning

confidence: 99%

“…Pharmacological modulation of K ATP with diazoxide (agonist) or glibenclamide (antagonist) was used to investigate the involvement of these channels in the gastroprotective effect of PrLP [ 22 ]. The animals ( n = 8 per group) were pretreated with glibenclamide (5 mg/kg, i.p.…”

Section: Methodsmentioning

confidence: 99%

The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal PlantPlumeria rubra: Involvement of the Latex Proteins in the NO/cGMP/K_ATPSignaling Pathway

Alencar

Pinheiro

Figueiredo³

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Plumeria rubra (Apocynaceae) is frequently used in folk medicine for the treatment of gastrointestinal disorders, hepatitis, and tracheitis, among other infirmities. The aim of this study was to investigate the gastroprotective potential of a protein fraction isolated from the latex of Plumeria rubra (PrLP) against ethanol-induced gastric lesions and describe the underlying mechanisms. In a dose-dependent manner, the pretreatment with PrLP prevented ethanol-induced gastric lesions in mice after single intravenous administration. The gastroprotective mechanism of PrLP was associated with the involvement of prostaglandins and balance of oxidant/antioxidant factors. Secondarily, the NO/cGMP/KATP pathway and activation of capsaicin-sensitive primary afferents were also demonstrated as part of the mechanism. This study shows that proteins extracted from the latex of P. rubra prevent gastric lesions induced in experimental animals. Also, the results support the use of the plant in folk medicine.

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“…They often occur in a C-20 backbone where isoprene units combine in different forms to give an array of diterpenes such as abietane [65], cembrane [66], guanacastepene A [67], quinonoid [68], jatropha [69], and cafestol and kahweol [70] types. These and several others may be found in coffee [71], tea [72], and Salvia spp.…”

Section: Bioactive Compounds Of Coffeementioning

confidence: 99%

Bioactive Micronutrients in Coffee: Recent Analytical Approaches for Characterization and Quantification

Nuhu

2014

ISRN Nutrition

107

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Production of coffee beans is an important lifeline for the economy of several countries in Latin America, Africa, and Asia. The brew from this well sought for cash crop is readily consumed due to its good sensory qualities owing to the presence of many micronutrients. Some of these chemical compounds possess biological activities, including antiproliferative, antioxidant, and antimicrobial effects. Four representative groups of these micronutrients, namely, caffeine, chlorogenic acid, diterpenes, and trigonelline, play key roles in these bioactive effects of coffee. In order to guarantee the quality of coffee products and to protect consumer interest and safeguard their well-being, it is extremely important to employ sensitive and accurate analytical methods in the characterization and quantitative determination of these bioactive constituents. This review aims to present recent applications in this regard.

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Gastroprotective effect of barbatusin and 3-beta-hydroxy-3-deoxibarbatusin, quinonoid diterpenes isolated from Plectranthus grandis, in ethanol-induced gastric lesions in mice

Abstract: The protective role for BBOH and BB affording gastroprotection against gastric damage induced by ethanol indicates that these compounds contribute for the activity of Plectranthus species. The different modes of action are probably related to differences in their chemical structure.

Cited by 27 publications

References 24 publications

Antisecretory, Gastroprotective, Antioxidant and Anti-Helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) Smith

Antisecretory, Gastroprotective, Antioxidant and Anti-Helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) Smith

The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal PlantPlumeria rubra: Involvement of the Latex Proteins in the NO/cGMP/K_ATPSignaling Pathway

Bioactive Micronutrients in Coffee: Recent Analytical Approaches for Characterization and Quantification

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Gastroprotective effect of barbatusin and 3-beta-hydroxy-3-deoxibarbatusin, quinonoid diterpenes isolated from Plectranthus grandis, in ethanol-induced gastric lesions in mice

Abstract: The protective role for BBOH and BB affording gastroprotection against gastric damage induced by ethanol indicates that these compounds contribute for the activity of Plectranthus species. The different modes of action are probably related to differences in their chemical structure.

Cited by 27 publications

References 24 publications

Antisecretory, Gastroprotective, Antioxidant and Anti-Helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) Smith

Antisecretory, Gastroprotective, Antioxidant and Anti-Helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) Smith

The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal PlantPlumeria rubra: Involvement of the Latex Proteins in the NO/cGMP/KATPSignaling Pathway

Bioactive Micronutrients in Coffee: Recent Analytical Approaches for Characterization and Quantification

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The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal PlantPlumeria rubra: Involvement of the Latex Proteins in the NO/cGMP/K_ATPSignaling Pathway