Gastroprotective effect of andrographolide sodium bisulfite against indomethacin-induced gastric ulceration in rats

Liu, Yuhong; Zhang, Zhenbiao; Zheng, Yifeng; Chen, Haiming; Yu, Xiu-Ting; Chen, Xiaoying; Xie, Zhaoxiong; Xie, Jianhui; Su, Zuowei; Feng, Xue-Xuan; Zeng, Hong‐Yan; Su, Zi‐Ren

doi:10.1016/j.intimp.2015.04.025

Cited by 59 publications

(35 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…ROS mainly comes from neutrophils which were driven by MPO under inflammatory circumstance. On the other hand, organism enzymatic and non-enzymatic defenses including GSH, SOD and CAT protect the host against the ROSinduced lipid peroxidation [28]. Our data supported a critical role of oxidative stress in the pathogenesis of the ethanol-induced gastric ulcer.…”

Section: Discussionsupporting

confidence: 75%

Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-кB pathway

Zhao

Gong

Wang

et al. 2015

International Immunopharmacology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 75%

Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-кB pathway

Zhao

Gong

Wang

et al. 2015

International Immunopharmacology

View full text Add to dashboard Cite

“…37 Glutathione (GSH), SOD, and catalase (CAT); prevents damage against ROS-dependent lipid peroxidation. 38 Various enzymatic antioxidants, such as SOD and CAT activities, increase to eliminate ROS, therefore, decrease ischemic damage. 10 In one study, SOD signifi cantly reduced in the R-IR model.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of p-Coumaric Acid as Free Oxygen Radical Scavenger in Experimental Renal Ischemia-Reperfusion Model

Güzel

Tanyeli

2018

Sakarya Medical Journal

View full text Add to dashboard Cite

Aim The aim of this study is to evaluate the antioxidant effect of p-Coumaric Acid (p-CA) on tissue damage due to ischemia-reperfusion in rat kidney tissue. ( Sakarya Med J 2018, 8(3):625-631)Methods Thirty-two 12-16 week-old Wistar Albino female rats weighing 200-250 g were used in this study. Rats underwent right nephrectomy intraperitoneally with an incision made in the dorsal region under ketamine (75 mg/kg) and xylazine (8 mg/kg) anesthesia. These rats were randomly divided into four groups in equal numbers (n = 8). Groups were classifi ed as the sham (S), renal ischemia-reperfusion (R-IR), 50 mg/kg p-CA with R-IR (p-CA 50), and 100 mg/kg p-CA with R-IR (p-CA 100). After the dorsum of all rats was opened and the right nephrectomy was performed, all groups except sham were clamped on the left renal artery and ischemia and reperfusion protocol was performed. P-CA was administered in two doses, 60 min before ischemia and 30 min before reperfusion. Total antioxidant levels (TAS), total oxidant level (TOS), superoxide dismutase (SOD), malondialdehyde (MDA), and myeloperoxidase (MPO) levels of left kidney were measured spectrophotometrically, and oxidative stress index (OSI) was calculated.Results TOS, MDA, MPO, and OSI values increased in R-IR group compared to S (p <0.01), while TAS and SOD values decreased. Increase in TAS and SOD values, a decrease in TOS, MDA, MPO, and OSI values were observed in P-CA applied groups (p <0.05).Conclusion Our fi ndings indicate that p-CA administration in renal ischemia-reperfusion injury may play a role in protecting tissue by reducing oxidant damage.

show abstract

“…SOD, an important intracellular enzymatic antioxidant, constitutes the first line of defence against ROS. It catalyses superoxide radicals into more stable hydrogen peroxide to protect cells from the toxic effect of ROS 1 . Unsaturated fatty acids are attacked by ROS in the biofilm system, and are converted into MDA through lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

“…Gastric ulcer is therefore extremely harmful to human health and is classified as a precancerous disease by the World Health Organization (WHO). This disease, characterized by necrosis, reduced blood flow, neutrophils infiltration, induction of oxidative stress and inflammatory mediator secretion, is predominantly caused by Helicobacter pylori , use of non-steroidal anti-inflammatory drugs (NSAIDs), alcohol, smoking and stress 1 . Alcohol consumption has been related to gastric mucosal lesions, including gastritis, gastric ulcer and even gastric carcinoma 2 .…”

Section: Introductionmentioning

confidence: 99%

Transformation of patchouli alcohol to β-patchoulene by gastric juice: β-patchoulene is more effective in preventing ethanol-induced gastric injury

Liu

Liang

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Pogostemonis Herba is a functional food approved in Asian countries. Its major constituent, patchouli alcohol (PA), possesses a gastroprotective effect and is reported to transform into β-patchoulene (β-PAE) under acidic conditions. To investigate whether β-PAE, the metabolite of PA, has a protective effect on the gastrointestinal tract, the formation of β-PAE by gastric juice and the anti-ulcerogenic potential of β-PAE against ethanol-induced gastric injury were evaluated. The Results indicated that PA was converted to β-PAE by rat gastric juice. Additionally, β-PAE was significantly better than PA at reducing the area of gastric ulcer. The overproduction of malondialdehyde, tumour necrosis factor-α, interleukin (IL)-1β, IL-6, Fas, FasL and caspase-3 was markedly inhibited by β-PAE while the underproduction of superoxide dismutase, glutathione and catalase was significantly improved. β-PAE also regulated the NF-κB and ERK1/2 signalling pathways. Our findings suggest that β-PAE has potential therapeutic efficacy for antiulcer treatment.

show abstract

Gastroprotective effect of andrographolide sodium bisulfite against indomethacin-induced gastric ulceration in rats

Cited by 59 publications

References 40 publications

Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-кB pathway

Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-кB pathway

Protective Effect of p-Coumaric Acid as Free Oxygen Radical Scavenger in Experimental Renal Ischemia-Reperfusion Model

Transformation of patchouli alcohol to β-patchoulene by gastric juice: β-patchoulene is more effective in preventing ethanol-induced gastric injury

Contact Info

Product

Resources

About