Transformation of patchouli alcohol to β-patchoulene by gastric juice: β-patchoulene is more effective in preventing ethanol-induced gastric injury

Liu, Yuhong; Liang, Jia-Li; Wu, Jingsong; Chen, Hanbin; Zhang, Zhenbiao; Yang, Hongmei; Chen, Liping; Chen, Haiming; Su, Zi‐Ren; Li, Yucui

doi:10.1038/s41598-017-05996-5

Cited by 36 publications

(31 citation statements)

References 28 publications

(29 reference statements)

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“…Oxidative stress plays a significant role in the pathogenesis of gastric injury induced by ethanol (29). Ethanol administration causes the overproduction of reactive oxygen species (ROS) and acceleration of lipid peroxidation to aggravate gastric injury (30). Because ROS could convert unsaturated fatty acids to MDA through lipid peroxidation, MDA is usually used as a marker of lipid peroxidation (31).…”

Section: Discussionmentioning

confidence: 99%

Pretreatment with Lactobacillus reuteri F-9-35 attenuates ethanol-induced gastric injury in rats

Sun¹,

Hou²,

Wang³

et al. 2018

Food & Nutrition Research

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BackgroundPrevious studies suggested that probiotics intervention may be one of the methods for preventing and/or treating gastric ulcer.ObjectiveThe aim of the study was to compare the preventive effects of a spaceflight mutant Lactobacillus reuteri F-9-35 and its wild type on ethanol-induced gastric injury in rats.DesignForty rats were randomly allocated into five groups: a normal group (NOR), ethanol group (EtOH), skim milk group (MILK), L. reuteri F-9-35 group (F935) and wild-type group (WT). The NOR and EtOH groups received 1 ml of distilled water by daily gavage for 14 days. The MILK group received 1 ml of skim milk alone, while the F935 and WT groups were administered 1 ml of skim milk containing the mutant and wild type (1 × 1010 colony-forming unit/ml) by daily gavage for 14 days, respectively. Acute gastric injury was induced by absolute alcohol 1 h after the final administration of different treatments, except for the NOR group.ResultsPretreatment with L. reuteri F-9-35, but not milk alone or milk with the L. reuteri wild type, showed significant reduction of ethanol-induced gastric injury, as evidenced by lowering of ulcer index, ulcer area (%), and histological lesion. F-9-35 decreased the levels of lipid peroxidation and myeloperoxidase and increased mucus, glutathione, and nitric oxide levels in gastric tissue. Moreover, F-9-35 inhibited the expression of proinflammatory genes including gastric tumor necrosis factor-α, interleukin-1β, and cyclooxygenase-2 and decreased the activity of nuclear factor kappa B (NF-κB).ConclusionThese findings indicated that L. reuteri F-9-35 pretreatment can attenuate ethanol-induced gastric injury in rats by inhibiting oxidative stress and inflammatory response. Together, L. reuteri F-9-35 has potential preventive efficacy on gastric ulcer.

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Section: Discussionmentioning

confidence: 99%

Pretreatment with Lactobacillus reuteri F-9-35 attenuates ethanol-induced gastric injury in rats

Sun¹,

Hou²,

Wang³

et al. 2018

Food & Nutrition Research

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“…The blood was immediately centrifuged at 3,500 rpm for 15 min at 4°C and the serum (supernatant) was collected according to the instructions of the manufacturer of nitric oxide (NO) and IL-6 (Nanjing Jiancheng Bioengineering Institute, Nanjing, China). The levels of NO and IL-6 in the serum were measured via the nitrate reductase and enzyme-linked immunosorbent assay method (Almasaudi et al, 2016; Liu et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

Treatment Mechanism of Gardeniae Fructus and Its Carbonized Product Against Ethanol-Induced Gastric Lesions in Rats

Zhang

Wang

et al. 2019

Front. Pharmacol.

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Gardeniae Fructus (GF) and carbonized GF (GFC) have been shown to exert a gastrointestinal protective effect and are frequently used in clinical practice for the treatment of hemorrhage and brown stool. In this study, we employed a combination of pharmacological methods and metabolomics in a rat model of ethanol-induced acute stomach ulcer to investigate the gastroprotective effect of GF and GFC water extracts and the potential mechanism involved in this process. The levels of nitric oxide (NO) and interleukin 6 (IL-6) in the plasma of rats were determined. The results showed that both GF and GFC reduced the ethanol-induced gastric lesions and expression of NO and IL-6 in these rats. Of note, 16 and 11 feature metabolites were filtered and identified in the GF and GFC groups, respectively. Both GF and GFC act by restoring the biosynthesis of valine, leucine, and isoleucine, and the metabolism of glycerophospholipids. Moreover, histological evaluation revealed that heat processing of GF to create GFC enhanced the gastric mucosa protective effect. Furthermore, heat processing converted the main pathway from alanine, aspartate, and glutamate metabolism, associated with GF, to histidine metabolism, associated with GFC. GF and GFC ameliorated gastric mucosa lesions in rats via reductions in NO production and inflammatory cytokine secretion, and the induction of prostaglandin E2.

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“…Prior to experimentation, all rats were fasted for 24 h with access only to clean water and accommodated in uniform mesh cages to prevent coprophagy. One hour after the final administration, animals except normal group were orally given with absolute ethanol (0.5 mL/100 g body weight) to establish acute gastric damage model, as previously mentioned method [19]. Blood samples from each rat were collected for serum biochemistry tests after 60 min, then animals were euthanized, and their stomachs were rapidly removed for further analysis.…”

Section: Methodsmentioning

confidence: 99%

Antioxidative and Anti-Inflammatory Effects of Water Extract of Acrostichum aureum Linn. against Ethanol-Induced Gastric Ulcer in Rats

Huang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Acrostichum aureum Linn., a medicinal pteridophyte growing in mangrove forests and coastal regions of tropical and subtropical areas worldwide, has been proved to possess various biological effects. However, the protective effect of Acrostichum aureum Linn. against gastric ulcer still remains unidentified. Therefore, the gastroprotective effect of the water extract of Acrostichum aureum Linn. (WEAC) was investigated in ethanol-induced gastric injury model. According to our results, pretreatment with WEAC (100, 200, and 400 mg/kg) could dramatically decrease the ulcer areas and ameliorate the pathological damage induced by alcohol in rat's gastric tissues. In addition, WEAC administration prevented the stomach from oxidative damage via markedly increasing the levels of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and decreasing the malondialdehyde (MDA). Besides, WEAC pretreatment alleviated inflammatory infiltration by reducing the secretion of proinflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as decreasing the protein expressions of phosphorylation of IκBα and p65. Taken together, WEAC exerted potential therapeutic efficacy for gastric ulceration, and this may be involved in the suppression of oxidative stress and inflammatory response.

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Transformation of patchouli alcohol to β-patchoulene by gastric juice: β-patchoulene is more effective in preventing ethanol-induced gastric injury

Cited by 36 publications

References 28 publications

Pretreatment with Lactobacillus reuteri F-9-35 attenuates ethanol-induced gastric injury in rats

Pretreatment with Lactobacillus reuteri F-9-35 attenuates ethanol-induced gastric injury in rats

Treatment Mechanism of Gardeniae Fructus and Its Carbonized Product Against Ethanol-Induced Gastric Lesions in Rats

Antioxidative and Anti-Inflammatory Effects of Water Extract of Acrostichum aureum Linn. against Ethanol-Induced Gastric Ulcer in Rats

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