Treatment Mechanism of Gardeniae Fructus and Its Carbonized Product Against Ethanol-Induced Gastric Lesions in Rats

Zhang, Xue; Wang, Yun; Li, Xiaoqing; Dai, Yejia; Wang, Qinghao; Wang, Guoyou; Liu, Depeng; Gu, Xiaoqing; Yu, Dao‐Yi; Ma, Yueming; Zhang, Cun

doi:10.3389/fphar.2019.00750

Cited by 19 publications

(12 citation statements)

References 50 publications

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“…Lipid metabolism: PCs are also important metabolites in lipid metabolism associated with the mechanism of ulcer occurrence [41]. In the present study, four kinds of lipid metabolism including glycerophospholipid, linoleic acid, sphingolipid and ether lipid metabolisms were found.…”

Section: Discussionsupporting

confidence: 51%

Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics

Wang

Yuan

et al. 2020

IJMS

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Gastric ulcer (GU), a prevalent digestive disease, has a high incidence and is seriously harmful to human health. Finding a natural drug with a gastroprotective effect is needed. Ocotillol, the derivate of ocotillol-type saponins in the Panax genus, possesses good anti-inflammatory activity. The study aimed to investigate the gastroprotective effect of ocotillol on acetic acid-induced GU rats. The serum levels of endothelin-1 (ET-1) and nitric oxide (NO), the gastric mucosa levels of epidermal growth factor, superoxide dismutase and NO were assessed. Hematoxylin and eosin staining of gastric mucosa for pathological changes and immunohistochemical staining of ET-1, epidermal growth factor receptors and inducible nitric oxide synthase were evaluated. A UPLC-QTOF-MS-based serum metabolomics approach was applied to explore the latent mechanism. A total of 21 potential metabolites involved in 7 metabolic pathways were identified. The study helps us to understand the pathogenesis of GU and to provide a potential natural anti-ulcer agent.

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Section: Discussionsupporting

confidence: 51%

Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics

Wang

Yuan

et al. 2020

IJMS

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“…Metabolomics represents a powerful discipline concerned with the comprehensive analysis of small molecules to discover biomarkers in biological systems (Schrimpe-Rutledge et al, 2016;Zhang et al, 2019). This method provides holistic insights into changes in the metabolic pathways during disease or drug treatment (Wu et al, 2017;Zheng et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Buzhongyiqi Decoction Protects Against Loperamide-Induced Constipation by Regulating the Arachidonic Acid Pathway in Rats

Zhao

Chen

et al. 2020

Front. Pharmacol.

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Constipation is a common gastrointestinal disorder without effective treatment approach. Buzhongyiqi decoction (BZYQD) is a classical formula that has been commonly used for gastrointestinal disorders for nearly 1,000 years. In this study, we aimed to investigate the protective effect of BZYQD against loperamide-induced constipation and its potential mechanism. Rats with loperamide-induced constipation were orally administered BZYQD. BZYQD treatment obviously increased the small intestinal transit rate and alleviated colon tissue pathological damage. Subsequently, serum metabolomics study was performed to identify the metabolites affected by BZYQD. Metabolomics identified that the levels of 17 serum metabolites, including prostaglandin E 2 (PGE 2), arachidonic acid (AA), and inositol, were significantly changed in BZYQD-treated group compared with those in the loperamide-induced group. Pathway analysis revealed that those metabolites were mainly associated with arachidonic acid metabolism, biosynthesis of unsaturated fatty acids, ascorbate and aldarate metabolism, inositol phosphate metabolism. Additionally, BZYQD treatment down-regulated the cyclooxygenase-2 expression and decrease production of the proinflammatory mediator PGE 2. Further study revealed that BZYQD administration decreased serum levels of the inflammatory factors IL-1b and TNF-a, inhibited phosphorylation of the nuclear transcription factor NF-kB, and down-regulated expression of the inflammatory factors IL-1b and IL-6 in the constipated rat colon. Moreover, BZYQD treatment also increased serum levels of inositol, motilin and gastrin, and promoted gastrointestinal motility. In conclusion, the present study suggested that BZYQD exerted a protective effect against loperamide-induced constipation, which may be associated with its role in regulation of multiple metabolic pathways.

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“…Arachidonic acid (AA) is one of the most biologically active n-6 polyunsaturated fatty acids and can be used to produce prostaglandins (PGs) by cyclooxygenase. AA plays a vital role in the process of in ammatory responses and is related to GUs [40,41] . It can be hydrolyzed, generated and released into multifarious active substances.…”

Section: Discussionmentioning

confidence: 99%

Study on the Protective Effect and the Metabolomics Features of Rutaecarpine on Ethanol-induced Acute Gastric Ulcer

Ren

Wei

Niu

et al. 2020

Preprint

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As a prevalent digestive disease, Gastric ulcer (GU) has a high incidence and is seriously harmful to human health. It is an urgent need to finding a natural drug with a gastroprotective effect. Rutaecarpine (RUT) is an alkaloid isolated from Evodia rutaecarpa Bentham (Rutaceae). This plant is a traditional Chinese medicine that has been treating gastrointestinal diseases for a long time. The present study aimed to investigate the effects of RUT on ethanol-induced acute GU in mice. After intragastrical administration of RUT for 3 consecutive days, acute GU were induced in the mice by ethanol treatment for 1.5 h. The expression levels of SOD, CAT, NO, ET-1 in serum and EGF, TNF-α, IL-1β, IL-6 in gastric tissues were measured by kits. In addition, hematoxylin and eosin (H&E) staining of gastric mucosa for pathological changes was evaluated. The serum metabolomics method based on ultra-high-performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) was used to explore the potential mechanism. A total of 7 potential metabolites involved in 9 metabolic pathways were identified. This study helps us to further understand the pathogenesis of GU and provide a potential natural anti-ulcer drug for clinic.

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Treatment Mechanism of Gardeniae Fructus and Its Carbonized Product Against Ethanol-Induced Gastric Lesions in Rats

Cited by 19 publications

References 50 publications

Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics

Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics

Buzhongyiqi Decoction Protects Against Loperamide-Induced Constipation by Regulating the Arachidonic Acid Pathway in Rats

Study on the Protective Effect and the Metabolomics Features of Rutaecarpine on Ethanol-induced Acute Gastric Ulcer

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