Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity

Neto, Luiz Jardelino de Lacerda; Ramos, Andreza Guedes Barbosa; Sales, Valterlúcio S.; Souza, Severino Denicio Gonçalves de; Santos, Antônia Thassya Lucas dos; Oliveira, Larissa Rolim de; Kerntopf, Marta Regina; Albuquerque, Thaís Rodrigues de; Coutinho, Henrique Douglas Melo; Quintans‐Júnior, Lucindo José; Wanderley, Almir Gonçalves; Menezes, Irwin Rose Alencar de

doi:10.1016/j.cbi.2016.11.020

Cited by 22 publications

(11 citation statements)

References 31 publications

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“…The damage to the gastric mucosa caused by ethanol impairs microcirculation, damaging the endothelium of the capillary vessels and causing microvascular stasis with reduction of tissue oxygen [84, 85]. This ulcerogenic agent still inhibits the production of prostaglandins, decreases mucus production [8], and induces free radical formation, increasing lipid peroxidation in the mucosa [86].…”

Section: Resultsmentioning

confidence: 99%

“…Ulcerative lesions occur due to an imbalance between the cytoprotective factors of the mucosa, such as the mucus-bicarbonate barrier and the presence of prostaglandins, and aggressive factors, among them reactive oxygen species (ROS) and hydrochloric acid [2, 3]. It is estimated that 10 to 20% of PU cases are associated with comorbidities such as hemorrhages, obstructions, and perforations, with a mortality rate ranging from 10 to 40%, with 2 to 14% of these mortality cases due to perforation [4–8]. Given this scenario, the scientific community has been continually challenged to contribute research to this area [2].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and Antiulcerogenic Activity of the Dry Extract of Pods of Libidibia ferrea Mart. ex Tul. (Fabaceae)

Prazeres

Aragão

Brito³

et al. 2019

Oxidative Medicine and Cellular Longevity

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Ethnomedicinal studies in the Amazon community and in the Northeast region of Brazil highlight the use of Libidibia ferrea fruits for the treatment of gastric problems. However, there are no data in the literature of this pharmacological activity. Thus, the aim of this paper is to provide a scientific basis for the use of the dry extract of L. ferrea pods (DELfp) for the treatment of peptic ulcers. Phytochemical characterization was performed by HPLC/MS. In vitro antioxidant activity was assessed using DPPH, ABTS, phosphomolybdenum, and superoxide radical scavenging activity. The gastroprotective activity, the ability to stimulate mucus production, the antisecretory activity, and the influence of -SH and NO compounds on the antiulcerogenic activity of DELfp were evaluated. The healing activity was determined by the acetic acid-induced chronic ulcer model. Anti-Helicobacter pylori activity was investigated. HPLC/MS results identified the presence of phenolic compounds, gallic acid and ellagic acid, in DELfp. The extract showed antioxidant activity in vitro. In ulcers induced by absolute ethanol and acidified ethanol, the ED50 values of DELfp were 113 and 185.7 mg/kg, respectively. DELfp (100, 200, and 400 mg/kg) inhibited indomethacin-induced lesions by 66.7, 69.6, and 65.8%, respectively. DELfp (200 mg/kg) reduced gastric secretion and H+ concentration in the gastric contents and showed to be independent of nitric oxide (NO) and dependent on sulfhydryl (-SH) compounds in the protection of the gastric mucosa. In the chronic ulcer model, DELfp reduced the area of the gastric lesion. DELfp also showed anti-H. pylori activity. In conclusion, DELfp showed antioxidant, gastroprotective, healing, and antiulcerogenic activities. The mechanism of these actions seems to be mediated by different pathways and involves the reduction of gastric secretion and H+ concentration, dependence on sulfhydryl compounds, and anti-H. pylori activity. All these actions support the medicinal use of this species in the management of peptic ulcers.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant and Antiulcerogenic Activity of the Dry Extract of Pods of Libidibia ferrea Mart. ex Tul. (Fabaceae)

Prazeres

Aragão

Brito³

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Hesperidin increased GSH and mucin levels and prevented oxidative cell injury in indomethacin and hypothermic restrain stress-induced ulceration models in rats [ 171 ]. Caryocar coriaceum extract, with gallic acid, chlorogenic acid, caffeic acid, rutin and quercetin as major constituents, exhibited antiulcer activity through opioid and α 2 -adrenergic receptors and primary afferent neurons sensitive to capsaicin in gastric ulcers induced by ethanol, acidified ethanol, acetic acid or indomethacin [ 169 ]. Anthocyanins extracted from Rubus coreanus have shown antiulcer effect in association with the regulation of the matrix metalloproteinase-2 activity, preventing lipid peroxidation and even increasing CAT, SOD and GPx activities [ 164 ].…”

Section: Plant Products and Phytochemicals As Antiulcerogenic And mentioning

confidence: 99%

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

et al. 2018

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In this narrative review, we have comprehensively reviewed the plant sources used as antiulcer agents. From traditional uses as herbal remedies, we have moved on to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential. A particular emphasis was also paid to Helicobacter pylori activity, with emphasis on involved mechanisms of action. Lastly, the issue of safety profile of these plant products has also been addressed.

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“…Wound healing is a dynamic process, that sequentially includes bleeding, coagulation, inflammatory, proliferative and remodelling phases . However, in diabetes mellitus (DM), wound healing is often impaired resulting in non‐healing, delayed healing or chronic skin ulcers .…”

Section: Introductionmentioning

confidence: 99%

Wound healing potential of Solanum xanthocarpum in streptozotocin-induced diabetic rats

Parmar

Shende

Katare

et al. 2018

Journal of Pharmacy and Pharmacology

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Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity

Cited by 22 publications

References 31 publications

Antioxidant and Antiulcerogenic Activity of the Dry Extract of Pods of Libidibia ferrea Mart. ex Tul. (Fabaceae)

Antioxidant and Antiulcerogenic Activity of the Dry Extract of Pods of Libidibia ferrea Mart. ex Tul. (Fabaceae)

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

Wound healing potential of Solanum xanthocarpum in streptozotocin-induced diabetic rats

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