Gastroprotective activity of the hydroethanolic extract and isolated compounds from the leaves of Solanum cernuum Vell.

Miranda, Mariza Abreu; Lemos, Marivane; Cowart, Kamila Alves; Rodenburg, Douglas L.; McChesney, James D.; Radwan, Mohamed M.; Furtado, Niege Araçari Jacometti Cardoso; Bastos, Jairo Kenupp

doi:10.1016/j.jep.2015.06.047

Cited by 20 publications

(18 citation statements)

References 47 publications

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“…(Fig. 10), comprising types of cyclic guanidine alkaloids, e.g., cernumidine ( 446 ) and isocernumidine ( 447 ) from the leaves of S. cernuum [109, 111, 112]. Bioactive long chain amides, 454 – 456 , exhibiting antimicrobial activity against Escherichia coli and Candida albicans were isolated from aerial parts of S. schimperianum [277].…”

Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Kaunda

Zhang

2019

Nat. Prod. Bioprospect.

103

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Over the past 30 years, the genus Solanum has received considerable attention in chemical and biological studies. Solanum is the largest genus in the family Solanaceae, comprising of about 2000 species distributed in the subtropical and tropical regions of Africa, Australia, and parts of Asia, e.g., China, India and Japan. Many of them are economically significant species. Previous phytochemical investigations on Solanum species led to the identification of steroidal saponins, steroidal alkaloids, terpenes, flavonoids, lignans, sterols, phenolic comopunds, coumarins, amongst other compounds. Many species belonging to this genus present huge range of pharmacological activities such as cytotoxicity to different tumors as breast cancer (4T1 and EMT), colorectal cancer (HCT116, HT29, and SW480), and prostate cancer (DU145) cell lines. The biological activities have been attributed to a number of steroidal saponins, steroidal alkaloids and phenols. This review features 65 phytochemically studied species of Solanum between 1990 and 2018, fetched from SciFinder, Pubmed, ScienceDirect, Wikipedia and Baidu, using “Solanum” and the species’ names as search terms (“all fields”).

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Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Kaunda

Zhang

2019

Nat. Prod. Bioprospect.

103

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“…Its folk name, ‘panaceia’, suggests that it can be used to treat many diseases, such as gastric ulcer, liver damage, skin infections, gonorrhea, as well as antitumor, anti‐arrhythmic agents. These uses have been reported for the aerial parts of S. cernuum …”

Section: Introductionmentioning

confidence: 77%

“…Phytochemical studies of this species reported flavonoids, guanidinic alkaloids, steroids, triterpenes and organic acids …”

Section: Introductionmentioning

confidence: 93%

“…These uses have been reported for the aerial parts of S. cernuum. [12,13] Phytochemical studies of this species reported flavonoids, guanidinic alkaloids, steroids, triterpenes and organic acids. [13 -16] Lopes et al isolated, for the first time, the guanidinic alkaloid cernumidine from the hydroalcoholic extract which was obtained from S. cernuum leaves.…”

Section: Introductionmentioning

confidence: 99%

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Chemosensitizing Effect of Cernumidine Extracted from Solanum cernuum on Bladder Cancer Cells in Vitro

Miranda

Mondal

Singh

et al. 2019

Chemistry & Biodiversity

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Cernumidine (CER) is a guanidinic alkaloid isolated from Solanum cernuum leaves. In this work, we investigated the cytotoxicity, chemosensitizing effect of cernumidine to cisplatin (cDDP) and the possible mechanism of action of the combination on bladder cancer cells. Cernumidine showed cytotoxicity and could sensitize bladder cancer cells to cisplatin. The combination of CER+cDDP inhibited cell migration on T24 cells. CER+cDDP down‐regulated MMP‐2/9 and p‐ERK1/2, while it increased EGFR activity corroborating the observed cell migration inhibition. Down‐regulation of Bcl‐2 and up‐regulation pro‐apoptotic Bax and further depletion of the mitochondrial membrane potential (ΔΨm) indicates that mitochondria play a central role in the combination treatment inducing the mitochondrial signaling pathway of apoptosis in T24 cells. Our data showed that the alkaloid cernumidine is worthy of further studies as a chemosensitizing agent to be used in complementary chemotherapy.

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“…A maceration and percolation process was employed to prepare the extracts of the different pomegranate parts [37]. For this, 30 g of each powder was macerated in 70% ethanol solution at room temperature for approximately 1 h, followed by percolation.…”

Section: Preparation Of the Extractsmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles Combined to Calcium Glycerophosphate: Antimicrobial and Antibiofilm Activities

et al. 2018

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Gastroprotective activity of the hydroethanolic extract and isolated compounds from the leaves of Solanum cernuum Vell.

Cited by 20 publications

References 47 publications

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Chemosensitizing Effect of Cernumidine Extracted from Solanum cernuum on Bladder Cancer Cells in Vitro

Green Synthesis of Silver Nanoparticles Combined to Calcium Glycerophosphate: Antimicrobial and Antibiofilm Activities

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