Ganoderic acid A from <i>Ganoderma lucidum</i> protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial composition

Lv, Xu-Cong; Wu, Qi; Cao, Ying-Jia; Lin, Yi‐Chen; Guo, Weiling; Rao, Pingfan; Zhang, Yanyan; Chen, Youting; Ai, Lianzhong; Ni, Li

doi:10.1039/d1fo03219d

Cited by 43 publications

(22 citation statements)

References 81 publications

(102 reference statements)

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“…38 Serum TC, TG, LDL-C and HDL-C levels are closely related to the occurrence of glucose and lipid metabolic disorders. 39 Our study showed that alloxan injection caused significant lipid metabolic abnormalities by increasing the TC, TG and LDL-C levels, while decreasing the HDL-C levels. However, p-synephrine administration might alleviate these conditions.…”

Section: Papermentioning

confidence: 55%

p-Synephrine ameliorates alloxan-induced diabetes mellitus through inhibiting oxidative stress and inflammation via suppressing the NF-kappa B and MAPK pathways

et al. 2023

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Section: Papermentioning

confidence: 55%

p-Synephrine ameliorates alloxan-induced diabetes mellitus through inhibiting oxidative stress and inflammation via suppressing the NF-kappa B and MAPK pathways

et al. 2023

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“…In addition, Prevotellaceae_NK3B31_group, uncultured_bacterium_f_Prevotellaceae, which are from Prevotellaceae also enriched in the BI group. The higher abundance of Prevotellaceae not only protects intestinal epithelial cells against oxidative stress, thereby, alleviating inflammatory symptoms in patients with inflammatory bowel diseases, but also beneficial for preventing obesity ( 103 , 104 ). Consistent with this study, Jerusalem artichoke inulin also enriched several genera of the Prevotelaceae family, and improved lipid metabolism in type 2 diabetes mice ( 105 ).…”

Section: Discussionmentioning

confidence: 99%

The lipid-lowering effects of fenugreek gum, hawthorn pectin, and burdock inulin

et al. 2023

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ObjectiveThe present study aimed to investigate the lipid-lowering effects and mechanisms of fenugreek gum (FG), hawthorn pectin (HP), and burdock inulin (BI) on high-fat diet (HFD)-induced hyperlipidemic rats.MethodsIn this study, high-fat diet (HFD) together with fat emulsion administration were used to establish hyperlipidemia model. The biochemical indices were assayed after administration of FG, HP, and BI. Their effects were evaluated by factor analysis. Alterations of gut microbiota and short chain fatty acids (SCFAs) in the cecal were assessed to illustrate the mechanism of lipid lowering.ResultsThe supplementation of FG, HP, and BI on HFD-fed rats decreased the levels of serum lipid and reduced the HFD-related liver and testicle damage. In the scatter plot of factor analysis, HP and BI were closer to normal fat diet (NFD) group in restoring the severity of hyperlipidemia, while FG and HP enhanced the excretion of cholesterol and bile acids (BAs). The levels of total SCFAs, especially butyric acid reduced by HFD were increased by HP. The ratio of Firmicutes to Bacteroidetes increased by HFD was reduced by HP and BI. FG, HP, and BI enriched intestinal probiotics, which were related to bile acid excretion or lipid-lowering.ConclusionsFG inhibited the absorption of cholesterol and enhanced the excretion of it, as well as increased the abundance of beneficial bacteria. While BI restored the imbalance of intestinal microbiota. HP enhanced the excretion of cholesterol and BAs, and restored the imbalance of intestinal microbiota. It was also utilized by intestinal microorganisms to yield SCFAs. This study suggested that FG, HP, and BI possessed the potential to be utilized as dietary supplements for obesity management.

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“…LPS intraperitoneal injection accelerates the production of ROS from inflammatory cells, which further aggravates ALI and leads to chronic inflammation. Whereas CAT serves as one of the primary ROS scavengers, and thus activation of CAT accelerates the elimination of ROS [ 24 ]. Our results display that the blockade of LPS-induced oxidative stress is associated with the amelioration of ALI.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus paracasei CCFM1223 Protects against Lipopolysaccharide-Induced Acute Liver Injury in Mice by Regulating the “Gut–Liver” Axis

et al. 2022

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Background: Lactobacillus paracasei CCFM1223, a probiotic previously isolated from the healthy people’s intestine, exerts the beneficial influence of preventing the development of inflammation. Methods: The aim of this research was to explore the beneficial effects of L. paracasei CCFM1223 to prevent lipopolysaccharide (LPS)-induced acute liver injury (ALI) and elaborate on its hepatoprotective mechanisms. Results: L. paracasei CCFM1223 pretreatment remarkably decreased the activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in mice with LPS treatment and remarkably recovered LPS-induced the changes in inflammatory cytokines (tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), interleukin (IL)-1β, IL-6, IL-17, IL-10, and LPS) and antioxidative enzymes activities (total antioxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT)). Metagenomic analysis showed that L. paracasei CCFM1223 pretreatment remarkably increased the relative abundance of Catabacter compared with the LPS group but remarkably reduced the relative abundance of [Eubacterium] xylanophilumgroup, ASF356, LachnospiraceaeNK4A136group, and Lachnoclostridium, which is closely associated with the inflammation cytokines and antioxidative enzymes. Furthermore, L. paracasei CCFM1223 pretreatment remarkably increased the colonic, serum, and hepatic IL-22 levels in ALI mice. In addition, L. paracasei CCFM1223 pretreatment remarkably down-regulated the hepatic Tlr4 and Nf-kβ transcriptions and significantly up-regulated the hepatic Tlr9, Tak1, Iκ-Bα, and Nrf2 transcriptions in ALI mice. Conclusions: L. paracasei CCFM1223 has a hepatoprotective function in ameliorating LPS-induced ALI by regulating the “gut–liver” axis.

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Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial composition

Abstract: Alcoholic liver injury is mainly caused by long-term excessive alcohol consumption and has become a global public threat to human health. It is well known that Ganoderma lucidum has excellent beneficial...

Cited by 43 publications

References 81 publications

p-Synephrine ameliorates alloxan-induced diabetes mellitus through inhibiting oxidative stress and inflammation via suppressing the NF-kappa B and MAPK pathways

p-Synephrine ameliorates alloxan-induced diabetes mellitus through inhibiting oxidative stress and inflammation via suppressing the NF-kappa B and MAPK pathways

The lipid-lowering effects of fenugreek gum, hawthorn pectin, and burdock inulin

Lactobacillus paracasei CCFM1223 Protects against Lipopolysaccharide-Induced Acute Liver Injury in Mice by Regulating the “Gut–Liver” Axis

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